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Ibritumomab (anti-CD20) - Primary antibody, specific to MS4A1, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab191926
Grouped product items
SKU Size
Availability
Price Qty
Ab191926-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab191926-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab191926-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90
Ab191926-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ibritumomab (anti-CD20) - Primary antibody, specific to MS4A1, Human IgG1
Synonyms APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | S7 | MS4A2 | MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | Membrane-spanning 4-domains
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms This protein may be involved in the regulation of B-cell activation and proliferation. Post-translational: Phosphorylated. Might be functionally regulated by protein kinase(s).
Host species Human
Specificity MS4A1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Ibritumomab (anti-CD20) is a murine IgG1k monoclonal antibody, and the complementary-determining region of Ibritumomab (anti-CD20) binds to CD20 antigen on B lymphocytes.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ibritumomab (anti-CD20) (Ab191926) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20 with Ibritumomab (anti-CD20) (Ab191926) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Ibritumomab (anti-CD20) (Ab191926) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20 (red) with Ibritumomab (anti-CD20) (Ab191926) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Ibritumomab (anti-CD20) (Ab191926) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20 (red) with Ibritumomab (anti-CD20) (Ab191926) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Ibritumomab (anti-CD20) (Ab191926) - ELISA
Immobilized Recombinant Hu-CD20-VLP protein at 2.0 μg/mL can bind Ibritumomab (anti-CD20) (Ab191926) with the EC₅₀ of 13.64 ng/mL.

Ibritumomab (anti-CD20) (Ab191926) - SEC
The purity of Ibritumomab (anti-CD20) (Ab191926) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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