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Recombinant p40 - DeltaNp63 Antibody - Primary antibody, specific to p40 - DeltaNp63, Rabbit IgG

    Application:
  • IHC
  • Host species: Rabbit
  • Reactive species: Human
  • Isotype: Rabbit IgG
  • Clone Number: MyR1-P40
  • Conjugation: Unconjugated
In stock
Item Number
Ab119740
Grouped product items
SKU Size
Availability
Price Qty
Ab119740-10μl
10μl
5
$49.90
Ab119740-50μl
50μl
1
$159.90
Ab119740-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
Ab119740-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,199.90

Recombinant (MyR1-P40); Rabbit anti Human p40 - DeltaNp63 Antibody; IHC; Unconjugated

Basic Description

Product Name Recombinant p40 - DeltaNp63 Antibody - Primary antibody, specific to p40 - DeltaNp63, Rabbit IgG
Synonyms 40 kDa Rab9 effector protein antibody | 8430412M01Rik antibody | 9530020d24rik antibody | AV073337 antibody | bA65N13.1 antibody | C87311 antibody | DKFZp686P1077 antibody | OTTHUMP00000022126 antibody | OTTMUSP00000012898 antibody | OTTMUSP00000012899 an
Specifications & Purity ExactAb™, Validated, Recombinant, 0.03 mg/mL
Host species Rabbit
Specificity p40 - DeltaNp63
Positive Control IHC: Human tonsil tissue.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human p40 - DeltaNp63 Antibody, Recombinant (MyR1-P40), could be used for IHC and so on.
Application
IHC: 1/100-1/200
Relevance
Differentiating between lung adenocarcinoma and squamous cell carcinoma is an important distinction with therapeutic implications. Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types, particularly lymphomas. p40 is a relatively unknown marker that recognizes ?Np63-a p63 isoform suggested to be highly specific for squamous/basal cells. p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 0.03 mg/mL
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Store at 2-8°C long term (36 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

TP63 Tbio Tumor protein 63 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant p40 - DeltaNp63 Antibody (Ab119740) - IHC
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue labelling p40 - DeltaNp63 with Recombinant p40 - DeltaNp63 Antibody (Ab119740) at 1/200 dilution. The section was incubated with Ab119740 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.​

Application

Application Dilution info
IHC

1/100 - 1/200

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0505287 Certificate of Analysis May 09, 2024 Ab119740
ZJ24F0505288 Certificate of Analysis May 09, 2024 Ab119740

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