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Recombinant KRIT1 Antibody - Primary antibody, specific to KRIT1, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab112390
Grouped product items
SKU Size
Availability
 Price Qty
Ab112390-10μl
10μl
2
$69.90
Ab112390-50μl
50μl
1
$209.90
Ab112390-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$349.90
Ab112390-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human KRIT1 Antibody; WB; Unconjugated

View related series
Click to view target information: KRIT1
Accession#: O00522 (1) CAM (1) CCM1 (1) Gene ID: 889 (1) KRIT1 (2)

Basic Description

Product Name Recombinant KRIT1 Antibody - Primary antibody, specific to KRIT1, Rabbit IgG
Synonyms KRIT 1 antibody | KRIT1 ankyrin repeat containing antibody | KRIT1 antibody | KRIT1_HUMAN antibody | KRIT1 | CAM | CCM1 | Ankyrin repeat containing protein Krit1 antibody | CAM antibody | CCM 1 antibody | CCM1 antibody | Cerebral cavernous malformations 1
Specifications & Purity ExactAb™, Validated, Recombinant, 1.2 mg/mL
Host species Rabbit
Specificity KRIT1
Immunogen A synthetic peptide derived from human KRIT1 (AA 2-107)
Positive Control WB: HeLa and HUVEC cel lysates.
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human KRIT1 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/1000
Protein Function：
Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits EKR1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin D1 levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.1 levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 1.2 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

KRIT1 Tbio Krev interaction trapped protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Recombinant KRIT1 Antibody (Ab112390) - Western Blot
All lanes: Recombinant KRIT1 Antibody (Ab112390) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 84 kDa
Observed band size: 83 kDa
Exposure time: 8.7 s

Application

Application Dilution info
WB

1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0607525 Certificate of Analysis Jun 27, 2024 Ab112390
ZJ24F0607524 Certificate of Analysis Jun 27, 2024 Ab112390

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