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Recombinant Frizzled 8 Antibody - Primary antibody, specific to FZD8, Rabbit IgG

COA COA
    Application:
  • WB
  • Host species: Rabbit
  • Reactive species: Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
In stock
Item Number
Ab104134
Grouped product items
SKU Size
Availability
 Price Qty
Ab104134-10μl
10μl
1
$76.90
Ab104134-50μl
50μl
4
$229.90
Ab104134-100μl
100μl
3
$329.90
Ab104134-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Recombinant; Rabbit anti Human Frizzled 8 Antibody; WB; Unconjugated

View related series
Click to view target information: FZD8
Accession#:Q9H461 (1) Frizzled 8 (1) FZD8 (1) Gene ID:8325 (1)

Basic Description

Product Name Recombinant Frizzled 8 Antibody - Primary antibody, specific to FZD8, Rabbit IgG
Synonyms Frizzled-8 | FZ8 | FZD8 | hFz8 | Frizzled 8 seven transmembrane spanning receptor antibody | frizzled 8, seven transmembrane spanning receptor antibody | Frizzled family receptor 8 antibody | frizzled homolog 8 (Drosophila) antibody | Frizzled homolog 8 a
Specifications & Purity ExactAb™, Validated, Recombinant, 1.0 mg/mL
Host species Rabbit
Specificity FZD8
Immunogen A synthetic peptide derived from human Frizzled 8 (AA 640-694).
Epitope HeLa and Jurkat lysates; Human endometrial carcinoma tissue.
Positive Control WB：Jurkat lysates
Conjugation Unconjugated
Grade ExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human Frizzled 8 Antibody, Recombinant, could be used for WB and so on.
Application:
WB: 1/500-1/1000
Protein Function
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Product Properties

Isotype Rabbit IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

FZD8 Tbio Frizzled-8 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Recombinant Frizzled 8 Antibody (Ab104134) - Western Blot
All lanes: Recombinant Frizzled 8 Antibody (Ab104134) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 73 kDa
Observed band size: 66,42 kDa
Exposure time: 5.6 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1101533 Certificate of Analysis Nov 02, 2023 Ab104134
ZJ23F1101534 Certificate of Analysis Nov 02, 2023 Ab104134

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