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Cemiplimab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to PDCD1, >95%, high purity, Human IgG4, Antibody of programmed cell death 1 (CD279), Antibody of programmed cell death 1 (CD279)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4
  • Conjugation: Unconjugated
In stock
Item Number
C412010
Grouped product items
SKU Size
Availability
Price Qty
C412010-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
C412010-1mg
1mg
5
$453.90
C412010-5mg
5mg
1
$1,889.90
C412010-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,401.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Cemiplimab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to PDCD1, >95%, high purity, Human IgG4, Antibody of programmed cell death 1 (CD279)
Synonyms hPD-1 | Protein PD-1
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity PDCD1
Application ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of programmed cell death 1 (CD279)
Product Description

Cemiplimab is a monoclonal IgG4 antibody with high affinity for programmed death receptor-1 (PD-1) that blocks PD-1/PD-L1 mediated T cell inhibition. It is commonly used in squamous cell skin cancer research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG4
Light Chain Type kappa
SDS-PAGE 26.0 kDa (Light Chain) & 49.9 kDa (Heavy Chain), under reducing conditions; 169.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1801342-60-8

Associated Targets(Human)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized hu-PD-1 at 2 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC₅₀ of 8.66 ng/mL.

Cemiplimab (anti-PD-1) (C412010) - SEC
The purity of Cemiplimab (anti-PD-1) (C412010) is more than 95% verified by HPLC.

Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 1.0 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC50 of 12.82 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202079 Certificate of Analysis Dec 20, 2023 C412010
ZJ23F1202078 Certificate of Analysis Dec 20, 2023 C412010

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