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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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C412010-100μg
|
100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$99.90
|
|
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C412010-1mg
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1mg |
5
|
$453.90
|
|
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C412010-5mg
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5mg |
1
|
$1,889.90
|
|
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C412010-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$3,401.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Cemiplimab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to PDCD1, >95%, high purity, Human IgG4, Antibody of programmed cell death 1 (CD279) |
|---|---|
| Synonyms | hPD-1 | Protein PD-1 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | PDCD1 |
| Application | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of programmed cell death 1 (CD279) |
| Product Description |
Cemiplimab is a monoclonal IgG4 antibody with high affinity for programmed death receptor-1 (PD-1) that blocks PD-1/PD-L1 mediated T cell inhibition. It is commonly used in squamous cell skin cancer research. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG4 |
| Light Chain Type | kappa |
| SDS-PAGE | 26.0 kDa (Light Chain) & 49.9 kDa (Heavy Chain), under reducing conditions; 169.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1801342-60-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized hu-PD-1 at 2 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC₅₀ of 8.66 ng/mL.
Cemiplimab (anti-PD-1) (C412010) - SEC
The purity of Cemiplimab (anti-PD-1) (C412010) is more than 95% verified by HPLC.
Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 1.0 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC50 of 12.82 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Dec 20, 2023 | C412010 | |
| Certificate of Analysis | Dec 20, 2023 | C412010 |
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