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PD-1/PD-L1

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  1. Acesulfame K
    Cas Number: 55589-62-3        EC Number: 259-715-3
    Formula:  C4H4KNO4S        Molecular Weight: 201.24
    IUPAC Name:  potassium;6-methyl-2,2-dioxo-1-oxa-2λ6-thia-3-azanidacyclohex-5-en-4-one
    SMILES:  CC1=CC(=O)[N-]S(=O)(=O)O1.[K+]
    InChIKey: WBZFUFAFFUEMEI-UHFFFAOYSA-M
    InChI:  InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
    Synonyms: 4-(1H-Tetrazol-1-yl)benzoic acid, AldrichCPR | INS-950 | 1-Phenyl-3-(pyridin-3-yl)urea | Acesulfame potassium, Europe...
  2. BMS202 (PD-1/PD-L1 inhibitor 2), Agonist of CB 1 receptor;Agonist of CB 2 receptor
    Cas Number: 1675203-84-5
    Formula:  C25H29N3O3        Molecular Weight: 419.5
    IUPAC Name:  N-[2-[[2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide
    SMILES:  CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC
    InChIKey: JEDPSOYOYVELLZ-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)
    Synonyms: N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide;PD1-PDL1 inhibit...
  3. Sulfamethoxypyridazine, Bacterial dihydropteroate synthase inhibitor
    Cas Number: 80-35-3        Compound CID:  5330
    Formula:  C11H12N4O3S        Molecular Weight: 280.3
    IUPAC Name:  4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
    SMILES:  COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N
    InChIKey: VLYWMPOKSSWJAL-UHFFFAOYSA-N
    InChI:  InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
    Synonyms: KBio2_006767 | Lentac | Slosul | Altezol | DTXSID5023611 | Opera_ID_698 | SPBio_002587 | Sulfamethoxypyridazinum | Di...
  4. Sulindac, Cyclooxygenase inhibitor
    Cas Number: 38194-50-2        EC Number: 250-893-8, 232-527-9, 253-819-2        Compound CID:  1548887
    Formula:  C20H17FO3S        Molecular Weight: 356.41
    IUPAC Name:  2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
    SMILES:  CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
    InChIKey: MLKXDPUZXIRXEP-MFOYZWKCSA-N
    InChI:  InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
    Synonyms: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)- | Aflodac | SULINDAC (USP M...
  5. (+)-JQ1 carboxylic acid
      Grade & Purity: 
    • ≥96%
    Cas Number: 202592-23-2
    Formula:  C19H17ClN4O2S        Molecular Weight: 400.88
    IUPAC Name:  2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetic acid
    SMILES:  CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)O)C4=CC=C(C=C4)Cl)C
    InChIKey: LJOSBOOJFIRCSO-AWEZNQCLSA-N
    InChI:  InChI=1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1
    Synonyms: EX-A1891 | MFCD28167916 | BCP20870 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorop...
  6. Panaxadiol
    Cas Number: 19666-76-3
    Formula:  C30H52O3        Molecular Weight: 460.7
    IUPAC Name:  (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[ashow more
    SMILES:  CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
    InChIKey: PVLHOJXLNBFHDX-XHJPDDKBSA-N
    InChI:  InChI=1S/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3show more
    Synonyms: 20(R)-Panaxadiol | (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5...
  7. Fraxinellone
      Grade & Purity: 
    • ≥98%
    Cas Number: 28808-62-0
    Formula:  C14H16O3        Molecular Weight: 232.28
    IUPAC Name:  (3R,3aR)-3-(furan-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzofuran-1-one
    SMILES:  CC1=C2C(=O)OC(C2(CCC1)C)C3=COC=C3
    InChIKey: XYYAFLHHHZVPRN-GXTWGEPZSA-N
    InChI:  InChI=1S/C14H16O3/c1-9-4-3-6-14(2)11(9)13(15)17-12(14)10-5-7-16-8-10/h5,7-8,12H,3-4,6H2,1-2H3/t12-,14+/m0/s1
    Synonyms: (3R,3aR)-3-(uran-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzouran-1-one | F1187 | NCI60_012928 | 4-(m-chlorophenyl)...
  8. (D)-PPA 1
    Cas Number: 1620813-53-7        Compound CID:  134160249
    Formula:  C70H98N20O21        Molecular Weight: 1555.67
    IUPAC Name:  (3R)-4-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(1R)-1-carboxy-2-phenylethyl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenshow more
    SMILES:  CC(C(C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCshow more
    InChIKey: ZEZZLZKHZPMELC-SDQLLZIZSA-N
    InChI:  InChI=1S/C70H98N20O21/c1-36(92)57(89-66(107)53-13-8-26-90(53)68(109)46(11-5-6-24-71)82-65(106)52(34-91)88-62(103)47(27-38-14-18-41(93)19-15-38)83-58(9show more
  9. (+)-JQ1 carboxylic acid
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 202592-23-2
    Formula:  C19H17ClN4O2S        Molecular Weight: 400.88
    IUPAC Name:  2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetic acid
    SMILES:  CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)O)C4=CC=C(C=C4)Cl)C
    InChIKey: LJOSBOOJFIRCSO-AWEZNQCLSA-N
    InChI:  InChI=1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1
    Synonyms: 202592-23-2|JQ-1 carboxylic acid|JQ-1 (carboxylic acid)|(+)-JQ1 carboxylic acid|JQ1 Carboxylic Acid|6H-Thieno[3,2-f][...
  10. AUNP-12
      Grade & Purity: 
    • 10mM in Water
    Cas Number: 1353563-85-5        Compound CID:  154701623
    Formula:  C142H226N40O48 C2HF3O2        Molecular Weight: 3375.57
    IUPAC Name:  (4S)-5-amino-4-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-2show more
    SMILES:  CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(Cshow more
    InChIKey: ZBJUUYIGBAQYBN-QKLNNLIKSA-N
    InChI:  InChI=1S/C142H226N40O48/c1-12-70(6)109(137(226)165-84(37-23-26-52-144)119(208)158-81(113(151)202)43-48-105(196)197)178-125(214)87(42-47-102(148)193)15show more
    Synonyms: AUNP-12|1353563-85-5|CHEMBL4635204|EX-A7438
  11. Acesulfame K
    Cas Number: 55589-62-3        EC Number: 259-715-3
    Formula:  C4H4KNO4S        Molecular Weight: 201.24
    IUPAC Name:  potassium;6-methyl-2,2-dioxo-1-oxa-2λ6-thia-3-azanidacyclohex-5-en-4-one
    SMILES:  CC1=CC(=O)[N-]S(=O)(=O)O1.[K+]
    InChIKey: WBZFUFAFFUEMEI-UHFFFAOYSA-M
    InChI:  InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
    Synonyms: 4-(1H-Tetrazol-1-yl)benzoic acid, AldrichCPR | INS-950 | 1-Phenyl-3-(pyridin-3-yl)urea | Acesulfame potassium, Europe...
  12. Atezolizumab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
      Application: 
    • Flow Cytometry
    Associated targets:  CD274
      Short Overview: Atezolizumab is a humanized monoclonal antibody IgG1, which resists programmed death factor ligand 1 (PD-L1) and is used for cancer research.    
      Species reactivity(Reacts with): Human    Isotype: Human IgG1    
      Conjugation: Unconjugated    
    Cas Number: 1380723-44-3        Compound CID:  168009942
    SMILES:  CC.CCCC(=NC(CC=C)C1=CC(=C(C=C1)N)S)C=C(C(=O)N(CCC(C)CC)C(C)CC)N.CC=CC(=CC)C(=O)C
    Synonyms: MPDL3280A
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