This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

Atezolizumab (anti-PD-L1) - Primary antibody, INHIBITOR of Programmed cell death 1 ligand 1 inhibitor, INHIBITOR of Programmed cell death 1 ligand 1 inhibitor

COA COA
    Application:
  • Flow Cytometry
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
A411996
Grouped product items
SKU Size
Availability
 Price Qty
A411996-1mg
1mg
8
$159.90
A411996-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$664.90
A411996-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,196.90
A411996-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,692.90
A411996-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9,694.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Atezolizumab is a humanized monoclonal antibody IgG1, which resists programmed death factor ligand 1 (PD-L1) and is used for cancer research.

View related series
Click to view target information: CD274
Accession#:Q9NZQ7 (26) Apoptosis (4276) Autophagy (1917) Gene ID:29126 (26) PD-L1 (22)

Basic Description

Product Name Atezolizumab (anti-PD-L1) - Primary antibody, INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
Synonyms MPDL3280A
Specifications & Purity Animal Free, ≥95%, See COA
Conjugation Unconjugated
Grade Animal Free
Action Type INHIBITOR
Mechanism of action INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
Product Description

A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC).

Product Properties

Concentration See COA
Storage Temp Protected from light,Store at -20°C
Shipped In Ice chest + Ice pads
Stability And Storage The diluted protein solution can be stored in cold storage at 2-8 degrees away from light for no more than 2 weeks. Long-term storage is not recommended. Avoid repeated freeze-thaw. The activity of freeze-thaw protein will decrease by about 5% each time.
CAS 1380723-44-3

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
ZJ23F0700555 Certificate of Analysis Jul 14, 2023 A411996
ZJ23F0700554 Certificate of Analysis Jul 14, 2023 A411996
ZJ23F0700553 Certificate of Analysis Jul 14, 2023 A411996
ZJ23F0700556 Certificate of Analysis Jul 14, 2023 A411996
ZJ23F0700552 Certificate of Analysis Jul 14, 2023 A411996
ZJ23F0200038 Certificate of Analysis Feb 15, 2023 A411996
ZJ23F0200037 Certificate of Analysis Feb 15, 2023 A411996

Alternative Products

  1. Envafolimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent
    Envafolimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

    Starting at $89.90

  2. Lesabelimab (anti-PD-L1)
    Lesabelimab (anti-PD-L1)

    Starting at $89.90

  3. Avelumab (anti-PD-L1), OTHER of Programmed cell death 1 ligand 1 other
    Avelumab (anti-PD-L1), OTHER of Programmed cell death 1 ligand 1 other

    Starting at $99.90

  4. PD-L1 Mouse mAb (APC)
    PD-L1 Mouse mAb (APC)

    Starting at $69.90

  5. MDX-1105 (anti-PD-L1)
    MDX-1105 (anti-PD-L1)

    Starting at $109.90

  6. Pacmilimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent
    Pacmilimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

    Starting at $59.90

  7. Lodapolimab (anti-PD-L1)
    Lodapolimab (anti-PD-L1)

    Starting at $109.90

  8. PD-L1 Mouse mAb (PE)
    PD-L1 Mouse mAb (PE)

    Starting at $56.90

  9. Recombinant PD-L1 Antibody (APC)
    Recombinant PD-L1 Antibody (APC)

    Starting at $79.90

  10. Cosibelimab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
    Cosibelimab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor

    Starting at $59.90

  11. PD-L1 Mouse mAb (FITC)
    PD-L1 Mouse mAb (FITC)

    Starting at $34.90

  12. PD-L1 Mouse mAb
    PD-L1 Mouse mAb

    Starting at $16.90

  13. PD-L1 Mouse mAb (Biotin)
    PD-L1 Mouse mAb (Biotin)

    Starting at $49.90

  14. Durvalumab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
    Durvalumab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor

    Starting at $39.90

  15. Socazolimab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
    Socazolimab (anti-PD-L1), INHIBITOR of Programmed cell death 1 ligand 1 inhibitor

    Starting at $69.90

  16. Recombinant PD-L1 Antibody (PE)
    Recombinant PD-L1 Antibody (PE)

    Starting at $66.90

  17. Sugemalimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent
    Sugemalimab (anti-PD-L1), BINDING AGENT of Programmed cell death 1 ligand 1 binding agent

    Starting at $149.90

  18. Manelimab (anti-PD-L1)
    Manelimab (anti-PD-L1)

    Starting at $109.90

  19. Sudubrilimab (anti-PD-L1)
    Sudubrilimab (anti-PD-L1)

    Starting at $109.90

  20. Garivulimab (anti-PD-L1)
    Garivulimab (anti-PD-L1)

    Starting at $109.90

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.