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BMS202 (PD-1/PD-L1 inhibitor 2) - ≥98%, high purity , CAS No.1675203-84-5, Agonist of CB 1 receptor;Agonist of CB 2 receptor

3 Citations COA COA
In stock
Item Number
B276435
Grouped product items
SKU Size
Availability
 Price Qty
B276435-1mg
1mg
1
$31.90
B276435-5mg
5mg
2
$129.90
B276435-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$207.90
B276435-25mg
25mg
3
$430.90
B276435-50mg
50mg
2
$757.90
B276435-100mg
100mg
2
$1,240.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

A\xa0small-molecule PD-1/PD-L1 interaction inhibitor

View related series
Apoptosis (4276) CB1 receptor Agonist (19) CB2 receptor Agonist (21) Immunology/Inflammation (1929) inhibitor (73) PD-1/PD-L1 (59)

Basic Description

Synonyms N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide;PD1-PDL1 inhibitor 2 | N-(2-{[2-Methoxy-6-(2-methyl-biphenyl-3-ylmethoxy)-pyridin-3-ylmethyl]-amino}-ethyl)-acetamide | N-[2-[[2-methoxy-6-[(2-methyl-3-ph
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor with an IC 50 of 18 nM. Biophysical studies demonstrate that BMS202 binds directly to PD-L1.\xa0Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of CB 1 receptor;Agonist of CB 2 receptor
Product Description

Shipped at 4°C. Store at -20°C.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Biphenyls and derivatives
Intermediate Tree Nodes Not available
Direct Parent Biphenyls and derivatives
Alternative Parents Toluenes  Aralkylamines  Alkyl aryl ethers  Pyridines and derivatives  Heteroaromatic compounds  Acetamides  Secondary carboxylic acid amides  Amino acids and derivatives  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Biphenyl - Aralkylamine - Toluene - Alkyl aryl ether - Pyridine - Heteroaromatic compound - Acetamide - Secondary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Azacycle - Organoheterocyclic compound - Secondary amine - Ether - Secondary aliphatic amine - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors Not available

Associated Targets(Human)

CNR1 Tclin Cannabinoid receptor 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CNR2 Tchem Cannabinoid receptor 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CD274 Tclin Programmed cell death 1 ligand 1 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HaCaT (4069 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T-cell line (174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jurkat (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-9 (1037 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CD274 Tclin Programmed cell death 1 ligand 1 (299 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC827 (1172 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

CHO-K1 (1115 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MC-38 (857 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CT26 (928 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772841
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772841
IUPAC Name N-[2-[[2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide
INCHI InChI=1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)
InChIKey JEDPSOYOYVELLZ-UHFFFAOYSA-N
Smiles CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC
Isomeric SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC
Alternate CAS 1675203-84-5
MeSH Entry Terms BMS202;N-(2-((2-Methoxy-6-(2-methyl-biphenyl-3-ylmethoxy)-pyridin-3-ylmethyl)-amino)-ethyl)-acetamide;PCC0208025
Molecular Weight 419.5
Reaxy-Rn 27956188
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27956188&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
H2217200 Certificate of Analysis Jun 05, 2023 B276435
H2217201 Certificate of Analysis Jun 05, 2023 B276435
H2217078 Certificate of Analysis Jun 05, 2023 B276435
H2111205 Certificate of Analysis Jun 21, 2022 B276435
H2111204 Certificate of Analysis Jun 21, 2022 B276435
H2111206 Certificate of Analysis Jun 21, 2022 B276435
H2111207 Certificate of Analysis Jun 21, 2022 B276435
H2111099 Certificate of Analysis Jun 21, 2022 B276435

Chemical and Physical Properties

Solubility 83 mg/mL (197.84 mM) in DMSO.
Molecular Weight 419.500 g/mol
XLogP3 3.600
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 10
Exact Mass 419.221 Da
Monoisotopic Mass 419.221 Da
Topological Polar Surface Area 72.500 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 526.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Ruoxia Wu, Jiaqing Xiong, Ting Zhou, Zhen Zhang, Zhen Huang, Sha Tian, Yongli Wang.  (2023)  Quercetin/Anti-PD-1 Antibody Combination Therapy Regulates the Gut Microbiota, Impacts Macrophage Immunity and Reshapes the Hepatocellular Carcinoma Tumor Microenvironment.  Frontiers in Bioscience-Landmark,  28  (12): (327). 
2. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv.  (2023)  Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  230  (123266). 
3. OuYang Y, Gao J, Zhao L, Lu J, Zhong H, Tang H, Jin S, Yue L, Li Y, Guo W, Xu Q, Lai Y..  (2021)  Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo..  J Med Chem,  64  (11.0): (7646-7666). 

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