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萝卜硫素

10篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
S111997-50mg
 50mg 现货 Stock Image
S111997-250mg
 250mg 现货 Stock Image
S111997-1g
 1g 期货 Stock Image
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查看相关系列
Apoptosis (7108) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Glucose Metabolism (3713) HDAC (161) Histone Modification (3105) Intrinsic Pathway (1438) Keap1-Nrf2 (107) NF-κB (756) 表观遗传学 (1497)
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基本描述

别名 莱菔硫烷 | 1-异硫氰酸基-4-(甲亚磺酰基)-丁烷
英文别名 AKOS006282481 | 4-Methylsulfinyl butyl isothiocyanate | Z1198151975 | BRD-A58955223-001-02-0 | 4-isothiocyanatobutyl methyl sulfoxide | R,S-Sulforaphane | (+/-)-sulforaphane | (R)-Sulforaphane;(-)-Sulforaphane;4-Methylsulfinylbutyl isothiocyanate | DL-Sul
规格或纯度 Moligand™, ≥95%
英文名称 DL-Sulforaphane
生化机理 具有抗癌特性的II相解毒酶的选择性诱导物。在十字花科蔬菜（包括西兰花）中发现的有机硫化合物。 萝卜硫素是一种在十字花科蔬菜中发现的抗癌、抗微生物和抗糖尿病化合物。它可诱导产生解毒酶，例如可引起异生素转化的醌还原酶和谷胱甘肽S-转移酶。萝卜硫素还可增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。它通过抑制LPS介导的iNOS、COX-2、IL-1β 和TNF-α的表达来调节炎症反应。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

Sulforaphane 是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1)，并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。


用途

用DL-萝卜硫素处理LNCaP前列腺癌细胞以研究其对雄激素受体的作用。用DL-萝卜硫素处理大鼠对研究其对马拉硫磷毒性的影响。

Product Introduction

Sulforaphane is a naturally occurring isothiocyanate found in cruciferous vegetables such as broccoli, cabbage, kale.It is an inducer of Nrf2.Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF - κ B.Sulforaphane increases heme oxygenase-1 (HO-1) and decreases the levels of reactive oxygen species (ROS).Sulforaphane induces cell cycle arrest and apoptosis.


Application

LNCaP prostate cancer cells were treated with DL sulforaphane to investigate its effect on androgen receptor.Treatment of rats with DL sulforaphane was used to study its effect on malathion toxicity.
纯度 ≥95%

关联靶点（人）

NFE2L2 Tchem 核因子红细胞2相关因子2(Nuclear factor erythroid 2-related factor 2) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MIF Tchem Macrophage migration inhibitory factor (979 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AHR Tclin Aryl hydrocarbon receptor (1071 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TGM2 Tchem Protein-glutamine gamma-glutamyltransferase (1221 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NQO1 Tchem Quinone reductase 1 (1746 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A-375 (9258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGS (1999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Caco-2 (12174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LoVo (4724 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H1975 (4994 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PANC-1 (6144 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SGC-7901 (2773 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SiHa (2051 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SW480 (6023 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THP-1 (11052 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-937 (7138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A-431 (6446 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H1299 (3248 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HONE1 cell line (118 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Jurkat (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-9 (1037 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMMC-7721 (5516 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H1650 (1118 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KEAP1 Tclin Kelch-like ECH-associated protein 1 (1736 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARPE-19 (321 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCC827 (1172 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hep 3B2 (2332 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L02 (4864 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PNT1A (47 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAFK Tbio BACH1/MafK (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryz Quinone oxidoreductase (288 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania infantum (5912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LLC-PK1 (2135 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDCK (10148 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MEF (1005 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nqo1 NAD(P)H dehydrogenase [quinone] 1 (1058 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lasR Transcriptional activator protein lasR (432 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rhlR Regulatory protein RhlR (305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 KEAP1/NRF2 (17 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HBZY-1 (111 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Peritoneal macrophage (1554 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name 1-isothiocyanato-4-methylsulfinylbutane
INCHI 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChi Key SUVMJBTUFCVSAD-UHFFFAOYSA-N
Smiles CS(=O)CCCCN=C=S
Isomeric SMILES CS(=O)CCCCN=C=S
分子量 177.29
Reaxy-Rn 1723237
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1723237&ln=

化学和物理性质

溶解性 Soluble in Chloroform, Dichloromethane, Diethyl Ether, methanol and DMSO, Soluble in Chloroform, Dichloromethane, Diethyl Ether, methanol and DMSO
密度 1.17
敏感性 对湿度、光线敏感
分子量 177.300 g/mol
XLogP3 1.400
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 177.028 Da
单同位素质量Monoisotopic Mass 177.028 Da
拓扑极表面积Topological Polar Surface Area 80.700 Ų
重原子数Heavy Atom Count 10
形式电荷Formal Charge 0
复杂度Complexity 152.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields,Gloves,half-mask respirator (EU),half-mask respirator (US),multi-purpose combination respirator cartridge (US)

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K2108458 分析证书 S111997
H2231736 分析证书 S111997
H2231737 分析证书 S111997
H2231747 分析证书 S111997
B2528055 分析证书 S111997
C2527112 分析证书 S111997
A2215039 分析证书 S111997
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引用文献

1. Zhang Y, Talalay P, Cho CG, Posner GH.  (1992)  A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure..  Proc Natl Acad Sci USA,  89  (6): (2399-403).  [PMID:1549603]
2. Pawlus AD, Su BN, Keller WJ, Kinghorn AD.  (2005)  An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni)..  J Nat Prod,  68  (12): (1720-2).  [PMID:16378361]
3. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.  (2013)  Sulforaphane as a potential protective phytochemical against neurodegenerative diseases..  Oxid Med Cell Longev,  2013  (415078).  [PMID:23983898]
4. Grabacka MM, Gawin M, Pierzchalska M.  (2014)  Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics..  Pharmaceuticals (Basel),  7  (9): (913-42).  [PMID:25192192]
5. Ao-Chun Yue, Xu-Dong Zhou, Hui-Ping Song, Xu-Han Liu, Ming-Jun Bi, Wei Han, Qin Li.  (2023)  Effect and molecular mechanism of Sulforaphane alleviates brain damage caused by acute carbon monoxide poisoning:Network pharmacology analysis, molecular docking, and experimental evidence.  ENVIRONMENTAL TOXICOLOGY,  [PMID:37860845] [10.1002/tox.24000]
6. Guangyang Liu, Xuan Zhang, Jian Wang, Lingyun Li, Jiayong Cao, Chen Yin, Yuan Liu, Ge Chen, Jun Lv, Xiaomin Xu, Jing Wang, Xiaodong Huang, Donghui Xu.  (2024)  Facile preparation of biomimetic mineralized COFs based on magnetic silk fibroin and its effective extraction of sulforaphane from cruciferous vegetables.  FOOD CHEMISTRY,  434  (137482).  [PMID:37722339] [10.1016/j.foodchem.2023.137482]
7. Linlin Jia, Xiaoqiang Peng, Zeyuan Deng, Bing Zhang, Hongyan Li.  (2023)  The structural characterization of polysaccharides from three cultivars of Moringa oleifera Lam. root and their effects on human intestinal microflora.  Food Bioscience,  52  (102482).  [10.1016/j.fbio.2023.102482]
8. Wenxiu Zheng, Wenhao Wang, Desheng Fu, Tianyu Zhang, Zhengrui Liang, Ling Yan, Changhong Liu, Lei Zheng.  (2023)  Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets.  FOOD RESEARCH INTERNATIONAL,  164  (112401).  [PMID:36738020] [10.1016/j.foodres.2022.112401]
9. Qi Zhang, Wanshuang Cao, Chenying Yang, Lixia Hong, Shanshan Geng, Hongyu Han, Caiyun Zhong.  (2023)  Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.  JOURNAL OF NUTRITIONAL BIOCHEMISTRY,  112  (109226).  [PMID:36435292] [10.1016/j.jnutbio.2022.109226]
10. Shaoqing Chen, Ziyu Wang, Li Liu, Yuting Li, Xinye Ni, Hong Yuan, Cheng Wang.  (2022)  Redox homeostasis modulation using theranostic AIE nanoparticles results in positive-feedback drug accumulation and enhanced drug penetration to combat drug-resistant cancer.  Materials Today Bio,  16  (100396).  [PMID:36060105] [10.1016/j.mtbio.2022.100396]
11. Yun Liu, Xue Wang, Bo Si, Tong Wang, Yun Wu, Ying Liu, Yemian Zhou, Haiyang Tong, Xinwei Zheng, An Xu.  (2022)  Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression.  ENVIRONMENT INTERNATIONAL,  165  (107327).  [PMID:35667343] [10.1016/j.envint.2022.107327]
12. Xi Zhao, Zhenhua Liu, Jie Gao, Hu Li, Xiaorong Wang, Yinchuan Li, Fei Sun.  (2020)  Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice.  TOXICOLOGY,  440  (152489).  [PMID:32416107] [10.1016/j.tox.2020.152489]
13. Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He.  (2024)  Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization.  Food Science and Human Wellness,  13  (2727).  [10.26599/FSHW.2022.9250220]
14. Qilei Wang, Zhenzhen Feng, Chan Shi, Xingang Lyu, DaiDi Fan.  (2024)  Sulforaphane nanoparticles coated with zein-propylene glycol alginate attenuate N-diethylnitrosamine-induced liver injury in mice.  JOURNAL OF FOOD SCIENCE,  89  (10): (6707-6719).  [PMID:39218937] [10.1111/1750-3841.17156]

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