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Autophagy Inducers
Autophagy is the process by which lysosomes degrade and recycle unnecessary or damaged cellular components. This mechanism helps sustain energy production during nutrient deprivation, supporting cell survival under stress. Beyond its role in adaptation, autophagy can also function as a form of programmed cell death, triggered by conditions such as development, differentiation, neurodegenerative disorders, stress, infection, and cancer.
While autophagy promotes survival in nutrient-starved cells, it also acts as a tumor-suppressive mechanism. Many chemotherapeutic agents induce the formation of abnormal proteins, and autophagy contributes to tumor suppression by degrading these proteins and damaged organelles, thereby restricting cellular proliferation.
Extended or excessive autophagy results in elevated protein and organelle turnover, which can ultimately lead to the death of cancer cells.
For a selection of compounds from Aladdin that stimulate autophagy in diverse disease models—including cancer, fibrosis, and infectious disease—please refer to the representative list provided below.
Aladdin catalog | Product name | Purity |
N-Acetyl-S-(N'-benzylthiocarbamoyl)-L-cysteine | ≥98% | |
Allicin | ≥80% mixture，10mM in DMSO | |
Apicidin | ≥98% | |
Arenobufagin | ≥98% | |
Asparaginase | ≥98%，100-300 units/mg protein | |
AZD2014 | ≥98% | |
Benzyl isothiocyanate | ≥98%，10mM in DMSO | |
BEZ235 | ≥99% | |
Carnosic acid | ≥96%，10mM in DMSO，analytical standard ≥97% | |
Chlorpromazine hydrochloride（CPZ） | ≥98%，analytical standard | |
Concanavalin A from Canavalia ensiformis (Jack bean) | BioReagent for cell culture，sterile，≥90%，Type IV, lyophilized powder | |
Dasatinib (monohydrate) | ≥98%，10mM in DMSO | |
Alvespimycin | ≥98% | |
Hydroxyecdysone | analytical standard ≥95%，≥93% powder，≥95% powder | |
Efavirenz | ≥98%，10mM in DMSO | |
Erlotinib HCl (OSI-744) | ≥99% | |
Esomeprazole potassium salt | ≥98% | |
Esomeprazole magnesium trihydrate | pharmaceutical grade | |
Etoposide | ≥98% | |
Etoposide phosphate | ≥98% | |
Everolimus | ≥98%，10mM in DMSO | |
Ginsenoside F2 | ≥98%，10mM in DMSO | |
4-Hydroxytamoxifen | ≥98%，10mM in DMSO | |
4-Hydroxytamoxifen | ≥98% E:Z isomers=50:50 | |
Melittin(trifluoroacetate salt) | ≥97% | |
MLN4924 | ≥98% | |
Nilotinib (AMN-107) | ≥99% | |
Obatoclax (GX15-070) | ≥98%，10mM in DMSO | |
Oridonin | ≥98%，analytical standard ≥98% | |
Piperine | analytical standard≥98%，≥97% | |
Piperlongumine | ≥97%，10mM in DMSO | |
PLX-4720 | ≥99% | |
PR-619 | ≥98%，10mM in DMSO | |
Pseudolaric Acid B | 10mM in DMSO，analytical standard ≥98%，≥98% | |
Puromycin aminonucleoside | 10 mg/mL in water，10mM in DMSO，≥98% | |
Puromycin dihydrochloride | ≥98%，BioReagent for cell culture，Ready Made Solution, from Streptomyces alboniger,10 mg/mL in H2O，Ultra pure | |
PX-866 | ≥98% | |
Saikosaponin D from Bupleurum falcatnum | ≥98%，10mM in DMSO | |
Stavudine (d4T) | ≥98%，10mM in DMSO | |
DL-Sulforaphane | 10mM in DMSO，≥70%，≥95% | |
4-Carvomenthenol | ≥95%，10mM in DMSO，≥98% | |
Valsartan | ≥98% | |
Vandetanib | ≥99% ,2mM in DMSO | |
Wogonoside | 10mM in DMSO，analytical standard ≥98%，≥98% | |
YM201636 | ≥96%，10mM in DMSO |
References:
1. Kobayashi S. Biol Pharm Bull. 2015;38(8):1098-103.
2. Mathew R, Karp CM, Beaudoin B, et al. Cell. 2009 Jun 12;137(6):1062-75.
3. Yang ZJ, Chee CE, Huang S, et al. Mol Cancer Ther. 2011 Sep;10(9):1533-41.
Aladdin: https://www.aladdinsci.com/
Categories: 技术文章