| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P107401-50mg |
50mg |
现货  |
|
| 别名 | 1-胡椒酰哌啶 |
|---|---|
| 英文别名 | BSPBio_002515 | MLS002153830 | Piperine, >=97% | starbld0008505 | NSC757803 | NSC-757803 | Piperidine, (E,E)- | Bioperine;1-Piperoylpiperidine | EINECS 202-348-0 | HY-N0144 | PIPERINE [WHO-DD] | (1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidi |
| 规格或纯度 | Moligand™, 分析标准品, ≥98% |
| 英文名称 | Piperine |
| 生化机理 | TRPV1激动剂（EC 50 = 38μM）。非选择性GABA A激动剂（EC 50 = 60μM）。在体内显示出神经保护，抗炎和抗氧化作用。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is sμggested that piperine exerts its chemopreventive effect by aμgmenting antioxidant defense system and modulating lipid peroxidation.A black pepper extract TRPV1 activator. Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. |
| 纯度 | ≥98% |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 202-348-0 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
| INCHI | 1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+ |
| InChi Key | MXXWOMGUGJBKIW-YPCIICBESA-N |
| Smiles | C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 |
| Isomeric SMILES | C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3 |
| 分子量 | 285.34 |
| Beilstein号 | 90741 |
| Reaxy-Rn | 90739 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=90739&ln= |
| 溶解性 | Soluble in ethanol (57 mg/ml), DMSO (57 mg/ml), alcohol (66.67 mg/ml), chloroform (588.24 mg/ml), and ether (27.78 mg/ml). |
|---|---|
| 密度 | 1.25 |
| 敏感性 | 对光线、湿度、空气敏感 |
| 熔点 | 128-132°C |
| 分子量 | 285.340 g/mol |
| XLogP3 | 3.500 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 285.136 Da |
| 单同位素质量Monoisotopic Mass | 285.136 Da |
| 拓扑极表面积Topological Polar Surface Area | 38.800 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 412.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 2 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 2 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H302: 吞食有害 |
| WGK Germany | 3 |
| RTECS | TN2321500 |
| Merck Index | 7472 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. Li R et al.. (2021) Piperine promotes autophagy flux by P2RX4 activation in SNCA/a-synuclein-induced Parkinson disease model.. Autophagy, (1-17). [PMID:34092198] |
| 2. 陈帅. (2020) Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core. Food Hydrocolloids, 1 (103): (105651). [10.1016/j.foodhyd.2020.105651] |
| 3. Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li. (2023) Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin. Food & Function, 14 (14): (6422-6431). [PMID:37395089] [10.1039/D3FO00617D] |
| 4. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai, Baoxin Zhang. (2023) Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis. BIOORGANIC CHEMISTRY, (106589). [PMID:37320912] [10.1016/j.bioorg.2023.106589] |
| 5. Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. (2023) The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. FOOD CHEMISTRY, 420 (136119). [PMID:37060667] [10.1016/j.foodchem.2023.136119] |
| 6. Mengmeng Wang, Bin Yang, Zongyi Ren, Jietao Liu, Chenwang Lu, Haifeng Jiang, Fei Ling, Gaoxue Wang, Tianqiang Liu. (2022) Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture. JOURNAL OF FISH DISEASES, 46 (3): (261-271). [PMID:36504104] [10.1111/jfd.13740] |
| 7. Ning Jia, Pengfei Guo, Kaiyuan Zhang, Chen Liu, Ruihao Chen, Zhe Liu, Qian Ye, Hongqiang Wang. (2022) Defect Passivation by Natural Piperine Molecule Enabling for Stable Perovskite Solar Cells with Efficiencies over 23%. ACS Sustainable Chemistry & Engineering, 10 (49): (16359–16367). [10.1021/acssuschemeng.2c05527] |
| 8. Zhang Chaohua, Gu Fenglin, Hu Weicheng, Wu Guiping, Chen Weijun, Dong Conghui, Niu Zhiqiang. (2022) Effect of extraction technique on chemical compositions and antioxidant activities of freeze-dried green pepper. Frontiers in Nutrition, 9 [PMID:36118756] [10.3389/fnut.2022.998840] |
| 9. Ligang Yu, Yong Li, Yukun Yang, Caixia Guo, Meiping Li. (2022) Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4646-4655). [10.1111/ijfs.15804] |
| 10. Song Lingyu, Wang Yan, Zhen Yunhuan, Li Dengke, He Xidong, Yang Hong, Zhang Huayang, Liu Qi. (2020) Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition. BIOTECHNOLOGY LETTERS, 42 (10): (2049-2058). [PMID:32500474] [10.1007/s10529-020-02923-z] |
| 11. Liu Kai, Liu Huijun, Li Zhendong, Li Wei, Li Liuxing. (2020) In vitro dissolution study on inclusion complex of piperine with ethylenediamine-β-cyclodextrin. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 96 (3): (233-243). [10.1007/s10847-020-00980-5] |
| 12. Hongyan He, Qi Zhang, Jian-Rong Wang, Xuefeng Mei. (2017) Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals. CRYSTENGCOMM, 19 (41): (6154-6163). [10.1039/C7CE01468F] |
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