基本描述

别名	6-姜辣醇 \| 姜辣素 \| 5-羟基-1-(4-羟基-3-甲氧基苯基)-3-癸酮, 3-癸酮,5-羟基-1-(4-羟基-3-甲氧基苯基)-,(5)-, 6-姜辣醇 \| (S)-5-羟基-1-(4-羟基-3-甲氧苯基)-3-癸酮 \| 6-姜辣醇
英文别名	3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)- \| HMS1361D09 \| (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone \| CCG-208214 \| HY-14615 \| [1-(4''-hydroxy-3''-methoxyphenyl)-5-hydroxy-3-decanone] \| 925QK2Z900 \| AKOS006222484
规格或纯度	Moligand™, 分析标准品, ≥98%
英文名称	[6]-Gingerol
生化机理	存在于生姜 (Zingiber officinale) 中的具有抗氧化活性的生物活性化合物，可用作抗炎剂和抗肿瘤剂。6-姜酚通过巨噬细胞下调促炎细胞因子的释放。已证明它可通过阻断经佛波酯刺激的小鼠皮肤中 p38 MAP 激酶和 NF-κB 的活化来抑制 COX-2 的表达。
应用	6-姜酚是一种具有抗氧化活性的生物活性化合物。 6-姜酚下降调节巨噬细胞炎性细胞因子释放。靠阻断p38 MAP激酶和NF -κB活性抑制COX - 2表达。
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
作用类型	激活剂
作用机制	TRPA1 激活剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	6-姜酚存在于生姜 (Zingiber officinale) 中的具有抗氧化活性的生物活性化合物。6-姜酚通过巨噬细胞下调促炎细胞因子的释放。已证明它可通过阻断经佛波酯刺激的小鼠皮肤中 p38 MAP 激酶和 NF-κB 的活化来抑制 COX-2 的表达。6-姜酚是一种具有抗氧化活性的生物活性化合物。 6-姜酚下降调节巨噬细胞炎性细胞因子释放。靠阻断p38 MAP激酶和NF -κB活性抑制COX - 2表达。 [6]-姜辣素是一种天然存在的植物酚，是生姜根茎中的活性刺激成分，已知其具有抗炎、抗肿瘤和抗氧化作用，因此可作为癌症治疗中的潜在候选物 Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties.
纯度	≥98%

关联靶点（人）

TRPA1 Tclin 瞬时受体电位阳离子通道亚家族A成员1(Transient receptor potential cation channel subfamily A member 1) (0 活性数据)

点击查看靶蛋白信息： TRPA1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

IIUPAC Name	(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
INCHI	1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
InChi Key	NLDDIKRKFXEWBK-AWEZNQCLSA-N
Smiles	CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O
Isomeric SMILES	CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O
UN Number	2811
分子量	294.39
Reaxy-Rn	2059333
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2059333&ln=

化学和物理性质

溶解性	Soluble in ethanol, benzene, ether, chloroform, methanol (1 mg/ml), and DMSO. Insoluble in water.
敏感性	对光和热敏感
分子量	294.400 g/mol
XLogP3	2.500
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	10
精确质量Exact Mass	294.183 Da
单同位素质量Monoisotopic Mass	294.183 Da
拓扑极表面积Topological Polar Surface Area	66.800 Å²
重原子数Heavy Atom Count	21
形式电荷Formal Charge	0
复杂度Complexity	293.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS06, GHS07
信号词	危险
危险声明	H301: 吞咽会中毒 H302: 吞食有害 H312: 皮肤接触有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H332: 吸入有害 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	HE0757000
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到9个结果

批号(Lot Number)	证书类型	货号
G2530374	分析证书	G111261
G2530375	分析证书	G111261
G2220602	分析证书	G111261
C2429458	分析证书	G111261
C2429463	分析证书	G111261
A2508056	分析证书	G111261
C2407484	分析证书	G111261
G2322734	分析证书	G111261
G2322738	分析证书	G111261

技术文档和文章

TRP 通道调节剂

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TRP 通道调节剂 TRPV TRPC TRPM TRPA TRPP TRPML

TRP Channel Modulators

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此产品的引用文献

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引用文献

1. Wala K et al.. (2022) Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma.. Molecules, 27 (9): [PMID:35566044]
2. Zhang Sheng-Feng, Li Jing, Wei Mei-Jie, Kong Fen-Ying, Zhang Rui, Wang Zhong-Xia, Fang Hai-Lin, Wang Wei. (2023) Highly sensitive electrochemical sensing of 6-gingerol in ginger using AuNPs-ZnO-rGO nanocomposites modified electrode. IONICS, 29 (4): (1571-1578). [10.1007/s11581-023-04890-7]
3. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu. (2023) Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (6): (2838-2847). [PMID:36700254] [10.1002/jsfa.12470]
4. Zhang Changrong, Huang Yongquan, Li Peiwu, Chen Xinlin, Liu Fengbin, Hou Qiuke. (2020) Ginger relieves intestinal hypersensitivity of diarrhea predominant irritable bowel syndrome by inhibiting proinflammatory reaction. BMC Complementary Medicine and Therapies, 20 (1): (1-10). [PMID:32928188] [10.1186/s12906-020-03059-3]
5. Ying Liu, ShiJi Deng, Zhi Zhang, Yue Gu, ShengNan Xia, XinYu Bao, Xiang Cao, Yun Xu. (2020) 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 883 (173294). [PMID:32681941] [10.1016/j.ejphar.2020.173294]
6. Lijun Zhen, Qiuyu Wei, Qilong Wang, Huiyun Zhang, Michael Adu-Frimpong, Caleb Kesse Firempong, Ximing Xu, Jiangnan Yu. (2020) Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, [PMID:30557068] [10.1080/10837450.2018.1558239]
7. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li. (2019) The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers. JOURNAL OF ETHNOPHARMACOLOGY, 228 (164). [PMID:30223050] [10.1016/j.jep.2018.09.022]
8. Qilong Wang, Qiuyu Wei, Qiuxuan Yang, Xia Cao, Qiang Li, Feng Shi, Shan Shan Tong, Chunlai Feng, Qingtong Yu, Jiangnan Yu, Ximing Xu. (2018) A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 535 (308). [PMID:29126908] [10.1016/j.ijpharm.2017.11.006]
9. Yang Xu, Qilong Wang, Yingshu Feng, Caleb Kesse Firempong, Yuan Zhu, Emmanuel Omari-Siaw, Yuanyuan Zheng, Zunqin Pu, Ximing Xu, Jiangnan Yu. (2016) Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. Journal of Functional Foods, 27 (703). [10.1016/j.jff.2016.10.007]
10. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng. (2015) Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae. JOURNAL OF CHROMATOGRAPHY A, 1376 (126). [PMID:25541090] [10.1016/j.chroma.2014.12.024]
11. Yanni Tai, Mintong Zhao, Feng Ding, Gelin Wu, Haibin Qu, Ping Gong, Yongjian Xie, Peng Zhou, Xingchu Gong. (2024) Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh-performance liquid chromatography method for the detection of phenolic compounds. PHYTOCHEMICAL ANALYSIS, [PMID:38462508] [10.1002/pca.3343]
12. Rui Wang, Pei-Feng Guo, Jing Nie, Xing Hu, Yu-Wei Wu, Shu Zhu, Bo-Ru Chen, Jian Li, Xin-An Zeng, Fei-Yue Xu. (2024) Inhibitory mechanism of xanthine oxidase by 6-, 8- and 10-gingerol: Enzyme kinetics, multi-spectroscopy and molecular simulations. JOURNAL OF MOLECULAR LIQUIDS, 410 (125605). [10.1016/j.molliq.2024.125605]
13. Jiehong He, Tian Wang, Yuanyuan Xie, Xianrui Liang. (2024) Preparation and characterization of self-assembling nanoparticles in Gancao Ganjiang decoction. JOURNAL OF MOLECULAR LIQUIDS, 407 (125174). [10.1016/j.molliq.2024.125174]
14. Zhen Liu, Ning Xu, Jumei Hou, Tong Liu. (2024) TbNACα negatively regulates Trichoderma breve T069 synthesis of ethyl caffeate and enhances antagonism of Sclerotium rolfsii1. Journal of Integrative Agriculture, [10.1016/j.jia.2024.01.030]

溶液计算器

摩尔浓度计算器

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分子量

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稀释计算器

计算配制储备溶液所需的稀释度。

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复溶计算器

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货	价格	数量
G111261-20mg	20mg	现货
G111261-100mg	100mg	现货

6-姜酚, TRPA1 激活剂

库存信息