| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G422764-1ml |
1ml |
现货  |
|
| 别名 | 6-姜辣醇 | 姜辣素 |
|---|---|
| 英文别名 | 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)- | HMS1361D09 | (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone | CCG-208214 | HY-14615 | [1-(4''-hydroxy-3''-methoxyphenyl)-5-hydroxy-3-decanone] | 925QK2Z900 | AKOS006222484 | [6]-Ging |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | [6]-Gingerol |
| 生化机理 | 凋亡，抗氧化剂和消炎药。SERCA激活剂（EC 50 = 4μM，心脏肌浆网中的Ca 2+ ATPase）。抑制COX-2表达。阻断p38 MAP激酶激活。在体内显示抗血管生成作用。口服具有活性 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | TRPA1 激活剂 |
| 产品介绍 |
6-姜酚存在于生姜 (Zingiber officinale) 中的具有抗氧化活性的生物活性化合物。6-姜酚通过巨噬细胞下调促炎细胞因子的释放。已证明它可通过阻断经佛波酯刺激的小鼠皮肤中 p38 MAP 激酶和 NF-κB 的活化来抑制 COX-2 的表达。 Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties. |
| IIUPAC Name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one |
|---|---|
| INCHI | 1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
| InChi Key | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
| Smiles | CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
| Isomeric SMILES | CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
| UN Number | 2811 |
| 分子量 | 294.39 |
| Reaxy-Rn | 2059333 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2059333&ln= |
| 敏感性 | 对光和热敏感 |
|---|---|
| 分子量 | 294.400 g/mol |
| XLogP3 | 2.500 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 10 |
| 精确质量Exact Mass | 294.183 Da |
| 单同位素质量Monoisotopic Mass | 294.183 Da |
| 拓扑极表面积Topological Polar Surface Area | 66.800 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 293.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS07 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H302: 吞食有害 H312: 皮肤接触有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H332: 吸入有害 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | HE0757000 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Zhang Sheng-Feng, Li Jing, Wei Mei-Jie, Kong Fen-Ying, Zhang Rui, Wang Zhong-Xia, Fang Hai-Lin, Wang Wei. (2023) Highly sensitive electrochemical sensing of 6-gingerol in ginger using AuNPs-ZnO-rGO nanocomposites modified electrode. IONICS, 29 (4): (1571-1578). [10.1007/s11581-023-04890-7] |
| 2. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu. (2023) Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (6): (2838-2847). [PMID:36700254] [10.1002/jsfa.12470] |
| 3. Zhang Changrong, Huang Yongquan, Li Peiwu, Chen Xinlin, Liu Fengbin, Hou Qiuke. (2020) Ginger relieves intestinal hypersensitivity of diarrhea predominant irritable bowel syndrome by inhibiting proinflammatory reaction. BMC Complementary Medicine and Therapies, 20 (1): (1-10). [PMID:32928188] [10.1186/s12906-020-03059-3] |
| 4. Ying Liu, ShiJi Deng, Zhi Zhang, Yue Gu, ShengNan Xia, XinYu Bao, Xiang Cao, Yun Xu. (2020) 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 883 (173294). [PMID:32681941] [10.1016/j.ejphar.2020.173294] |
| 5. Lijun Zhen, Qiuyu Wei, Qilong Wang, Huiyun Zhang, Michael Adu-Frimpong, Caleb Kesse Firempong, Ximing Xu, Jiangnan Yu. (2020) Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, [PMID:30557068] [10.1080/10837450.2018.1558239] |
| 6. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li. (2019) The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers. JOURNAL OF ETHNOPHARMACOLOGY, 228 (164). [PMID:30223050] [10.1016/j.jep.2018.09.022] |
| 7. Qilong Wang, Qiuyu Wei, Qiuxuan Yang, Xia Cao, Qiang Li, Feng Shi, Shan Shan Tong, Chunlai Feng, Qingtong Yu, Jiangnan Yu, Ximing Xu. (2018) A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 535 (308). [PMID:29126908] [10.1016/j.ijpharm.2017.11.006] |
| 8. Yang Xu, Qilong Wang, Yingshu Feng, Caleb Kesse Firempong, Yuan Zhu, Emmanuel Omari-Siaw, Yuanyuan Zheng, Zunqin Pu, Ximing Xu, Jiangnan Yu. (2016) Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. Journal of Functional Foods, 27 (703). [10.1016/j.jff.2016.10.007] |
| 9. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng. (2015) Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae. JOURNAL OF CHROMATOGRAPHY A, 1376 (126). [PMID:25541090] [10.1016/j.chroma.2014.12.024] |
| 10. Yanni Tai, Mintong Zhao, Feng Ding, Gelin Wu, Haibin Qu, Ping Gong, Yongjian Xie, Peng Zhou, Xingchu Gong. (2024) Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh-performance liquid chromatography method for the detection of phenolic compounds. PHYTOCHEMICAL ANALYSIS, [PMID:38462508] [10.1002/pca.3343] |
| 11. Rui Wang, Pei-Feng Guo, Jing Nie, Xing Hu, Yu-Wei Wu, Shu Zhu, Bo-Ru Chen, Jian Li, Xin-An Zeng, Fei-Yue Xu. (2024) Inhibitory mechanism of xanthine oxidase by 6-, 8- and 10-gingerol: Enzyme kinetics, multi-spectroscopy and molecular simulations. JOURNAL OF MOLECULAR LIQUIDS, 410 (125605). [10.1016/j.molliq.2024.125605] |
| 12. Jiehong He, Tian Wang, Yuanyuan Xie, Xianrui Liang. (2024) Preparation and characterization of self-assembling nanoparticles in Gancao Ganjiang decoction. JOURNAL OF MOLECULAR LIQUIDS, 407 (125174). [10.1016/j.molliq.2024.125174] |
| 13. Zhen Liu, Ning Xu, Jumei Hou, Tong Liu. (2024) TbNACα negatively regulates Trichoderma breve T069 synthesis of ethyl caffeate and enhances antagonism of Sclerotium rolfsii1. Journal of Integrative Agriculture, [10.1016/j.jia.2024.01.030] |
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