Pim激酶 - JAK/STAT 信号通路 - 按“信号通路”分类 - 小分子和化合物库

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AZD1208,泛Pim激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 1204144-28-4

分子式: C₂₁H₂₁N₃O₂S 分子量: 379.48

IUPAC Name: (5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione

SMILES: C1CC(CN(C1)C2=C(C=CC=C2C3=CC=CC=C3)C=C4C(=O)NC(=O)S4)N

InChIKey: MCUJKPPARUPFJM-UWCCDQBKSA-N

InChI: 1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1

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SGI-1776 游离碱

规格或纯度 :

Moligand™

≥98%

CAS号: 1025065-69-3 Compound CID : 24795070

分子式: C₂₀H₂₂F₃N₅O 分子量: 405.42

IUPAC Name: N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

SMILES: CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

InChIKey: MHXGEROHKGDZGO-UHFFFAOYSA-N

InChI: 1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)

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SMI-4a,ATP竞争性Pim激酶抑制剂

规格或纯度 :

≥98%

CAS号: 438190-29-5 Compound CID : 1361334

分子式: C₁₁H₆F₃NO₂S 分子量: 273.23

IUPAC Name: (5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

SMILES: C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2

InChIKey: NGJLOFCOEOHFKQ-YVMONPNESA-N

InChI: 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

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CX-6258,pan-Pim激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 1202916-90-2

分子式: C₂₆H₂₄ClN₃O₃ 分子量: 461.94

IUPAC Name: (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one

SMILES: CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O

InChIKey: KGBPLKOPSFDBOX-CJLVFECKSA-N

InChI: 1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+

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PIM-1 Inhibitor 2

规格或纯度 :

Moligand™

≥98%

CAS号: 477845-12-8 Compound CID : 2765355

分子式: C₁₇H₁₁ClN₄O 分子量: 322.75

IUPAC Name: 4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine

SMILES: C1=CC(=CC=C1C2=C3C=C(C=CC3=NO2)C4=NC(=NC=C4)N)Cl

InChIKey: AQVFETGXIRKVAQ-UHFFFAOYSA-N

InChI: 1S/C17H11ClN4O/c18-12-4-1-10(2-5-12)16-13-9-11(3-6-15(13)22-23-16)14-7-8-20-17(19)21-14/h1-9H,(H2,19,20,21)

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CRT0066101 dihydrochloride

规格或纯度 :

≥98%

CAS号: 1883545-60-5 Compound CID : 136664697

分子式: C₁₈H₂₂N₆O.2HCl 分子量: 411.33

IUPAC Name: 2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol;dihydrochloride

SMILES: CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl

InChIKey: CXYCRYGNFKDPRH-FMOMHUKBSA-N

InChI: 1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);2*1H/t14-;;/m1../s1

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栎草亭

规格或纯度 :

≥98%

CAS号: 90-18-6 Compound CID : 5281680

分子式: C₁₅H₁₀O₈ 分子量: 318.23

IUPAC Name: 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxychromen-4-one

SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O)O)O)O)O

InChIKey: ZVOLCUVKHLEPEV-UHFFFAOYSA-N

InChI: 1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H

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NSC 31205

规格或纯度 :

≥98%

CAS号: 6320-51-0

分子式: C₁₁H₉NO₃S 分子量: 235.257

IUPAC Name: (5Z)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

SMILES: COC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2

InChIKey: VRUKGUBMRBLJJW-TWGQIWQCSA-N

InChI: 1S/C11H9NO3S/c1-15-8-4-2-7(3-5-8)6-9-10(13)12-11(14)16-9/h2-6H,1H3,(H,12,13,14)/b9-6-

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AKK1-IN-1

规格或纯度 :

Moligand™

≥98%

CAS号: 1093222-27-5

分子式: C₂₀H₁₃N₅O 分子量: 339.35

IUPAC Name: N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide

SMILES: C1=CC(=CN=C1)C(=O)NC2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C#N

InChIKey: JTSLALYXYSRPGW-UHFFFAOYSA-N

InChI: 1S/C20H13N5O/c21-9-13-3-5-14(6-4-13)16-8-17-18(12-24-19(17)23-11-16)25-20(26)15-2-1-7-22-10-15/h1-8,10-12H,(H,23,24)(H,25,26)

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SMI-16a

规格或纯度 :

≥98%

CAS号: 587852-28-6 Compound CID : 25102785

分子式: C₁₃H₁₃NO₃S 分子量: 263.31

IUPAC Name: (5E)-5-[(4-propoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

SMILES: CCCOC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2

InChIKey: GBWOSXZUTXXXQF-DHZHZOJOSA-N

InChI: 1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8+

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TP-3654

规格或纯度 :

≥98%

CAS号: 1361951-15-6 Compound CID : 66598080

分子式: C₂₂H₂₅F₃N₄O 分子量: 418.46

IUPAC Name: 2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol

SMILES: CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O

InChIKey: XRNVABDYQLHODA-UHFFFAOYSA-N

InChI: 1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)

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Uzansertib phosphate

规格或纯度 :

≥98%

CAS号: 2088852-47-3 Compound CID : 126673672

分子式: C₂₆H₂₆F₃N₅O₃.H₃O₄P 分子量: 611.51

IUPAC Name: N-[(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide;phosphoric acid

SMILES: CC1CN(CC(C1O)N)C2=C3CCC(C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O.OP(=O)(O)O

InChIKey: CYYVLFVRZDZABX-SEDYQSMDSA-N

InChI: 1S/C26H26F3N5O3.H3O4P/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28;1-5(2,3)4/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(See more

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