Uzansertib phosphate

Pim 抑制剂

COA

级别和纯度:

≥98%

CAS编号: 2088852-47-3
分子式: C₂₆H₂₆F₃N₅O₃.H₃O₄P
分子量: 611.51
PubChem编号: 126673672

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
I414189-1mg	1mg	现货
I414189-5mg	5mg	现货
I414189-10mg	10mg	现货
I414189-25mg	25mg	现货
I414189-50mg	50mg	现货

查看相关系列

JAK/STAT Signaling (508) Pim (31)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	磷酸乌赞塞替布
英文别名	INCB053914 phosphate \| PIM inhibitor 1 phosphate
规格或纯度	≥98%
英文名称	Uzansertib phosphate
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Uzansertib (INCB053914) phosphate 是一种具有口服活性的，ATP 竞争性泛-PIM 激酶抑制剂，对于 PIM1，PIM2 和 PIM3 的 IC50 分别为 0.24 nM，30 nM 和 0.12 nM。Uzansertib phosphate 对多种血液肿瘤细胞系具有广泛的抗增殖活性。 Information INCB053914 INCB053914 is a novel, ATP-competitive, small molecule, pan-inhibitor of PIM kinases with IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. In vitro INCB053914 potently inhibits the activities of all three PIM isozymes with half maximal inhibitory concentration (IC50) values in the order of PIM1 ≈ PIM3 < PIM2. It is highly selective against a panel of more than 50 kinases (>475-fold selectivity), except for RSK2 for which INCB053914 has modest potency (IC50 = 7.1 μM). No kinase other than Per-Arnt-Sim (PAS) kinase is significantly inhibited by INCB053914 (100 nM). In cell proliferation assays, INCB053914 is active as a single agent in the majority of cell lines derived from different hematological malignancies, including MM, AML, DLBCL, MCL and T-ALL, with IC50 values ranging from 3-300 nM. INCB053914 synergizes with a variety of cytotoxic and targeted agents, reducing the viability of a panel of hematological tumor cell lines. In vivo single-agent INCB053914 inhibits Bcl-2-associated death promoter protein phosphorylation and dose-dependently inhibited tumor growth in acute myeloid leukemia and multiple myeloma xenografts. INCB053914 inhibits tumor growth in a dose-dependent manner in mice bearing MOLM-16 (AML) or KMS-12-BM (MM) tumors. A pharmacokinetic analysis of INCB053914 plasma concentrations up to 16 hours post oral administration in MOLM-16 and KMS-12-BM tumor-bearing mice suggests dose proportionality. Cell Research(from reference) Concentrations：0-1 μM Incubation Time：2 h
纯度	≥98%

名称和识别符

IIUPAC Name	N-[(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide;phosphoric acid
INCHI	1S/C26H26F3N5O3.H3O4P/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28;1-5(2,3)4/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37);(H3,1,2,3,4)/t12-,17+,20+,25+;/m0./s1
InChi Key	CYYVLFVRZDZABX-SEDYQSMDSA-N
Smiles	CC1CN(CC(C1O)N)C2=C3CCC(C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O.OP(=O)(O)O
PubChem CID	126673672
分子量	611.51

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 50 mg/mL (81.76 mM);
敏感性	对湿度敏感
分子量	611.500 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	7
氢键受体数Hydrogen Bond Acceptor Count	14
可旋转键计数Rotatable Bond Count	4
精确质量Exact Mass	611.176 Da
单同位素质量Monoisotopic Mass	611.176 Da
拓扑极表面积Topological Polar Surface Area	202.000 Å²
重原子数Heavy Atom Count	42
形式电荷Formal Charge	0
复杂度Complexity	853.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	4
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到8个结果

批号(Lot Number)	证书类型	货号
B2426675	分析证书	I414189
B2426681	分析证书	I414189
B2426682	分析证书	I414189
B2426685	分析证书	I414189
B2426686	分析证书	I414189
B2426684	分析证书	I414189
B2426660	分析证书	I414189
B2426668	分析证书	I414189

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Uzansertib phosphate

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器