Atibuclimab (anti-CD14), CD14 分子抗体

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human)
亚型: Human IgG4
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab170495-100μg	100μg	现货
Ab170495-1mg	1mg	现货
Ab170495-5mg	5mg	现货
Ab170495-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD14

Accession#:P08571 (61) CD14 (65) CD14 molecule Antibody (1) Gene ID:929 (61)

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基本信息

产品名称	Atibuclimab (anti-CD14), CD14 分子抗体
别名	阿替布利单抗 \| 阿替布单抗(抗 CD14)
英文别名	CD 14 antibody \| CD_antigen=CD14 antibody \| CD14 antibody \| CD14 antigen antibody \| CD14 molecule antibody \| CD14_HUMAN antibody \| LPS-R antibody \| Mo2 antibody \| Monocyte differentiation antigen CD14 antibody \| Monocyte differentiation antigen CD14 urina
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD14
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抗体
作用机制	CD14 分子抗体

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4
轻链亚型	kappa
SDS-PAGE	28.0 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 167.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2417175-94-9
分子类型	抗体

关联靶点（人）

CD14 Tbio 单核细胞分化抗原CD14(Monocyte differentiation antigen CD14) (0 活性数据)

点击查看靶蛋白信息： CD14

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Atibuclimab (anti-CD14) (Ab170495)

Atibuclimab (anti-CD14) (Ab170495) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD14 (red) with Atibuclimab (anti-CD14) (Ab170495). Goat Anti-Human IgG (FITC) (Ab175834) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Atibuclimab (anti-CD14) (Ab170495)

Atibuclimab (anti-CD14) (Ab170495) - SEC
The purity of Atibuclimab (anti-CD14) (Ab170495) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F1012720	分析证书	Ab170495
ZJ24F1012719	分析证书	Ab170495
ZJ24F1012718	分析证书	Ab170495
ZJ24F0303669	分析证书	Ab170495
ZJ24F0303668	分析证书	Ab170495
ZJ24F0303667	分析证书	Ab170495

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引用文献

1. Verbon A, Dekkers PE, ten Hove T, Hack CE, Pribble JP, Turner T, Souza S, Axtelle T, Hoek FJ, van Deventer SJ et al.. (2001) IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans.. J Immunol, 166 (5): (3599-605). [PMID:11207321]
2. Axtelle T, Pribble J. (2001) IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis.. J Endotoxin Res, 7 (4): (310-4). [PMID:11717588]
3. Verbon A, Meijers JC, Spek CA, Hack CE, Pribble JP, Turner T, Dekkers PE, Axtelle T, Levi M, van Deventer SJ et al.. (2003) Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.. J Infect Dis, 187 (1): (55-61). [PMID:12508146]
4. Olszyna DP, Verbon A, Pribble JP, Turner T, Axtelle T, van Deventer SJ, van der Poll T. (2003) Effect of IC14, an anti-CD14 antibody, on plasma and cell-associated chemokines during human endotoxemia.. Eur Cytokine Netw, 14 (3): (158-62). [PMID:14656690]
5. Axtelle T, Pribble J. (2003) An overview of clinical studies in healthy subjects and patients with severe sepsis with IC14, a CD14-specific chimeric monoclonal antibody.. J Endotoxin Res, 9 (6): (385-9). [PMID:14733726]
6. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL et al.. (2013) Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.. J Med Chem, 56 (11): (4206-23). [PMID:23656327]
7. Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. (1989) Monocyte antigen CD14 is a phospholipid anchored membrane protein.. Blood, 73 (1): (284-9). [PMID:2462937]
8. Haziot A, Ferrero E, Köntgen F, Hijiya N, Yamamoto S, Silver J, Stewart CL, Goyert SM. (1996) Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice.. Immunity, 4 (4): (407-14). [PMID:8612135]
9. Ferrero, E E and Goyert, S M SM.. (1988) Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14.. Nucleic acids research, (11): [PMID:2453848]
10. Setoguchi, M M and 5 more authors.. (1989) Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones.. Biochimica et biophysica acta, (7): [PMID:2472171]
11. Bazil, V V and 6 more authors.. (1989) Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14.. Molecular immunology, [PMID:2779588]
12. Haziot, A A and 5 more authors.. (1988) The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:3385210]
13. da Silva Correia, J J, Soldau, K K, Christen, U U, Tobias, P S PS and Ulevitch, R J RJ.. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.. The Journal of biological chemistry, (15): [PMID:11274165]
14. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
15. Triantafilou, Martha M and 6 more authors.. (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.. The Journal of biological chemistry, (13): [PMID:16880211]
16. Nakajima, Toshiaki T and 6 more authors.. (2008) Natural selection in the TLR-related genes in the course of primate evolution.. Immunogenetics, [PMID:18810425]
17. Murakami, Kosaku K and 13 more authors.. (2012) Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.. FEBS letters, (17): [PMID:22265692]
18. Kelley, Stacy L SL, Lukk, Tiit T, Nair, Satish K SK and Tapping, Richard I RI.. (2013) The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:23264655]
19. Estruch, Montserrat M and 5 more authors.. (2013) CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes.. Atherosclerosis, [PMID:23880187]
20. Kim, Sun-Mi SM, Kim, Bo-Young BY, Eo, Seong-Kug SK, Kim, Chi-Dae CD and Kim, Koanhoi K.. (2015) 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide.. Biochimica et biophysica acta, [PMID:25497142]
21. Yang, Linlin L and 12 more authors.. (2015) SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.. PloS one, [PMID:25965346]

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Atibuclimab (anti-CD14), CD14 分子抗体

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基本信息

产品属性

关联靶点（人）

作用机制

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

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