基本信息

产品名称	Recombinant CD14 Antibody
别名	MY23抗原 \| LPS受体 \| 细菌脂多糖膜受体 \| CD14 抗体 \| Anti-CD14抗体 \| 小鼠抗人CD14抗体
英文别名	CD14 antigen \| CD14 molecule \| CD14 \| monocyte differentiation antigen CD14 \| Myeloid cell-specific leucine-rich glycoprotein \| CD 14 antibody \| CD_antigen=CD14 antibody \| CD14 antibody \| CD14 antigen antibody \| CD14 molecule antibody \| CD14_HUMAN antibod
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.
宿主种属	小鼠(Mouse)
特异性	Human CD14
种属反应性	人(Human)
免疫原	Human Thymocytes followed by peripheral blood mononuclear cells.
阳性对照	Flow Cytometry: Human peripheral blood monocytes
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 8.0
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C long time. Upon delivery aliquot. Avoid freeze / thaw cycle.
分子类型	抗体

关联靶点（人）

CD14 Tbio 单核细胞分化抗原CD14(Monocyte differentiation antigen CD14) (0 活性数据)

点击查看靶蛋白信息： CD14

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant CD14 Antibody (Ab219597)

Recombinant CD14 Antibody (Ab219597) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD14 with Recombinant CD14 Antibody (Ab219597) conjugated with biotin (right panel) at 1 μg/mL for 1 hour at 4°C, compared with Mouse IgG (Ab170221) - Isotype Control (left panel) and detected with Alexa Fluor 488-conjugated affinipure goat anti-Mouse IgG.

Flow Cytometry: Recombinant CD14 Antibody (Ab219597)

Recombinant CD14 Antibody (Ab219597) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD14 (red) with Recombinant CD14 Antibody (Ab219597) conjugated with biotin at 1 μg/mL for 1 hour at 4°C, and detected with Alexa Fluor 488-conjugated affinipure goat anti-Mouse IgG. Blue - Isotype control, compared with Mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.