货号 (SKU)

包装规格

是否现货

价格

数量

Ab176555-100μg

100μg

现货

Ab176555-1mg

1mg

现货

Ab176555-5mg

5mg

现货

Ab176555-10mg

10mg

期货

基本信息

产品名称	Tesnatilimab (anti-NKG2D)
别名	特拉佐利单抗 \| 特斯那替利单抗（抗 NKG2D）
英文别名	CD314 antibody \| CD314 antigen antibody \| D12S2489E antibody \| Killer cell lectin like receptor subfamily K member 1 antibody \| Killer cell lectin-like receptor subfamily K member 1 antibody \| KLR antibody \| KLRC4 KLRK1 readthrough antibody \| KLRK1 antibo
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	KLRK1
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	26.6 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 165.7 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2242758-08-1
分子类型	抗体

关联靶点（人）

KLRK1 Tbio NKG2-D II 型整合膜蛋白(NKG2-D type II integral membrane protein) (0 活性数据)

点击查看靶蛋白信息： KLRK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Tesnatilimab (anti-NKG2D) (Ab176555)

Tesnatilimab (anti-NKG2D) (Ab176555) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling NKG2D with Tesnatilimab (anti-NKG2D) (Ab176555) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Tesnatilimab (anti-NKG2D) (Ab176555)

Tesnatilimab (anti-NKG2D) (Ab176555) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling NKG2D (red) with Tesnatilimab (anti-NKG2D) (Ab176555) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Tesnatilimab (anti-NKG2D) (Ab176555)

Tesnatilimab (anti-NKG2D) (Ab176555) - SEC
The purity of Tesnatilimab (anti-NKG2D) (Ab176555) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0202865	分析证书	Ab176555
ZJ24F0202864	分析证书	Ab176555
ZJ24F0202863	分析证书	Ab176555

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引用文献

1. Houchins JP, Yabe T, McSherry C, Bach FH. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.. J Exp Med, 173 (4): (1017-20). [PMID:2007850]
2. Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.. Nat Immunol, [PMID:11224526]
3. Glienke, J J and 7 more authors.. (1998) The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.. Immunogenetics, [PMID:9683661]
4. Wu, J J and 6 more authors.. (1999) An activating immunoreceptor complex formed by NKG2D and DAP10.. Science (New York, N.Y.), (30): [PMID:10426994]
5. Wu, J J, Cherwinski, H H, Spies, T T, Phillips, J H JH and Lanier, L L LL.. (2000) DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.. The Journal of experimental medicine, (2): [PMID:11015446]
6. Shum, Benny P BP and 8 more authors.. (2002) Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:11751968]
7. Radaev, S S, Rostro, B B, Brooks, A G AG, Colonna, M M and Sun, P D PD.. (2001) Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.. Immunity, [PMID:11754823]
8. Sutherland, Claire L CL and 5 more authors.. (2002) UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:11777960]
9. Vivier, Eric E, Tomasello, Elena E and Paul, Pascale P.. (2002) Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?. Current opinion in immunology, [PMID:11973127]
10. McFarland, Benjamin J BJ, Kortemme, Tanja T, Yu, Shuyuarn F SF, Baker, David D and Strong, Roland K RK.. (2003) Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands.. Structure (London, England : 1993), [PMID:12679019]
11. Bacon, Louise L and 5 more authors.. (2004) Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15240696]
12. Rosen, David B DB and 5 more authors.. (2004) A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15294961]
13. Chan, Camie W CW and 11 more authors.. (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.. Nature medicine, [PMID:16444266]
14. Eagle, Robert A RA, Traherne, James A JA, Hair, James R JR, Jafferji, Insiya I and Trowsdale, John J.. (2009) ULBP6/RAET1L is an additional human NKG2D ligand.. European journal of immunology, [PMID:19658097]
15. Zafirova, Biljana; Wensveen, Felix M; Gulin, Maja and Polić, Bojan.. (2011) Regulation of immune cell function and differentiation by the NKG2D receptor.. Cellular and molecular life sciences : CMLS, [PMID:21898152]
16. Raulet, David H DH, Gasser, Stephan S, Gowen, Benjamin G BG, Deng, Weiwen W and Jung, Heiyoun H.. (2013) Regulation of ligands for the NKG2D activating receptor.. Annual review of immunology, [PMID:23298206]
17. Hosomi, Shuhei S and 11 more authors.. (2013) CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.. European journal of immunology, [PMID:23696226]
18. Zuo, Jianmin J and 14 more authors.. (2017) A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.. Science signaling, (30): [PMID:28559451]
19. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.. Science, [PMID:10426993]

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Tesnatilimab (anti-NKG2D)

库存信息

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关联靶点（人）

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Tesnatilimab (anti-NKG2D)

库存信息

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基本信息

产品属性

关联靶点（人）

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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