货号 (SKU)

包装规格

是否现货

价格

数量

Ab175598-100μg

100μg

现货

Ab175598-1mg

1mg

现货

Ab175598-5mg

5mg

现货

Ab175598-10mg

10mg

期货

基本信息

产品名称	Milatuzumab (anti-CD74), CD74 抗体
别名	米拉组单抗 \| 米拉珠单抗（抗 CD74）
英文别名	CD 74 antibody \| CD74 antibody \| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody \| CD74 antigen antibody \| CD74 molecule antibody \| CD74 molecule, major histocompatibility complex, class II in
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD74
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	拮抗剂
作用机制	CD74 抗体

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.7 kDa (Light Chain) & 50.7 kDa (Heavy Chain), under reducing conditions; 199.9 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	899796-83-9
分子类型	抗体

关联靶点（人）

CD74 Tchem HLA II 类组织相容性抗原伽玛链(HLA class II histocompatibility antigen gamma chain) (0 活性数据)

点击查看靶蛋白信息： CD74

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CD74 Tchem HLA-DR antigens-associated invariant chain (25 活性数据)

点击查看靶蛋白信息： CD74

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Milatuzumab (anti-CD74) (Ab175598)

Milatuzumab (anti-CD74) (Ab175598) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD74 (red) with Milatuzumab (anti-CD74) (Ab175598). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Milatuzumab (anti-CD74) (Ab175598)

Milatuzumab (anti-CD74) (Ab175598) - SEC
The purity of Milatuzumab (anti-CD74) (Ab175598) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F1013205	分析证书	Ab175598
ZJ24F1013206	分析证书	Ab175598
ZJ24F1013207	分析证书	Ab175598
ZJ24F0403992	分析证书	Ab175598
ZJ24F0403991	分析证书	Ab175598
ZJ24F0403990	分析证书	Ab175598

可替换产品

引用文献

1. Sapra P, Stein R, Pickett J, Qu Z, Govindan SV, Cardillo TM, Hansen HJ, Horak ID, Griffiths GL, Goldenberg DM. (2005) Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys.. Clin Cancer Res, 11 (14): (5257-64). [PMID:16033844]
2. Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, Govindan S, Goldenberg DM. (2007) CD74: a new candidate target for the immunotherapy of B-cell neoplasms.. Clin Cancer Res, 13 (18 Pt 2): (5556s-5563s). [PMID:17875789]
3. Claesson L, Larhammar D, Rask L, Peterson PA. (1983) cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.. Proc Natl Acad Sci USA, 80 (24): (7395-9). [PMID:6324166]
4. Kudo J, Chao LY, Narni F, Saunders GF. (1985) Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.. Nucleic Acids Res, 13 (24): (8827-41). [PMID:3001652]
5. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R. (2003) MIF signal transduction initiated by binding to CD74.. J Exp Med, 197 (11): (1467-76). [PMID:12782713]
6. Alissa A Hare,Lin Leng,Sunilkumar Gandavadi,Xin Du,Zoe Cournia,Richard Bucala,William L Jorgensen. (2010-08-24) Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).. Bioorganic & medicinal chemistry letters, 20 ((19)): (5811-5814). [PMID:20728358]
7. William L Jorgensen,Alexander Trofimov,Xin Du,Alissa A Hare,Lin Leng,Richard Bucala. (2011-07-02) Benzisothiazolones as modulators of macrophage migration inhibitory factor.. Bioorganic & medicinal chemistry letters, 21 ((15)): (4545-4549). [PMID:21719283]
8. Cournia Z, Leng L, Gandavadi S, Du X, Bucala R, Jorgensen WL.. (2009) Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.. J Med Chem, 52 (2): (416-424). [PMID:19090668] [10.1021/jm801100v]
9. Jorgensen WL, Gandavadi S, Du X, Hare AA, Trofimov A, Leng L, Bucala R.. (2010) Receptor agonists of macrophage migration inhibitory factor.. Bioorg Med Chem Lett, 20 (23): (7033-7036). [PMID:20971005] [10.1016/j.bmcl.2010.09.118]
10. Riberdy, J M JM, Newcomb, J R JR, Surman, M J MJ, Barbosa, J A JA and Cresswell, P P.. (1992) HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.. Nature, (3): [PMID:1448172]
11. O'Sullivan, D M DM, Larhammar, D D, Wilson, M C MC, Peterson, P A PA and Quaranta, V V.. (1986) Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3459184]
12. Strubin, M M, Mach, B B and Long, E O EO.. (1984) The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.. The EMBO journal, [PMID:6586420]
13. Ghosh, P P, Amaya, M M, Mellins, E E and Wiley, D C DC.. (1995) The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.. Nature, (30): [PMID:7477400]
14. Jasanoff, A A, Wagner, G G and Wiley, D C DC.. (1998) Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.. The EMBO journal, (1): [PMID:9843486]
15. Guncar, G G, Pungercic, G G, Klemencic, I I, Turk, V V and Turk, D D.. (1999) Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.. The EMBO journal, (15): [PMID:10022822]
16. Charest, Alain A and 6 more authors.. (2003) Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).. Genes, chromosomes & cancer, [PMID:12661006]

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Milatuzumab (anti-CD74), CD74 抗体

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基本信息

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关联靶点（人）

作用机制

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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Milatuzumab (anti-CD74), CD74 抗体

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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溶液计算器

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