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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175511-100μg |
100μg |
现货 ![]() |
| |
| Ab175511-1mg |
1mg |
现货 ![]() |
| |
| Ab175511-5mg |
5mg |
现货 ![]() |
| |
| Ab175511-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Domagrozumab (anti-GDF8), 生长/分化因子 8 抑制剂 |
|---|---|
| 别名 | 多玛洛珠单抗 | 多玛格珠单抗(抗 GDF8) |
| 英文别名 | GDF 8 antibody | GDF-8 antibody | GDF8 antibody | GDF8_HUMAN antibody | Growth differentiation factor 8 antibody | Growth/differentiation factor 8 antibody | MSLHP antibody | MSTN antibody | Myostatin antibody | OTTHUMP00000163498 antibody | GDF-8 | GDF8 |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | MSTN |
| 种属反应性 | 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 生长/分化因子 8 抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 28.8 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 204.8 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 1629605-31-7 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Domagrozumab (anti-GDF8) (Ab175511) - Flow Cytometry
pLVX-puro-SYMX01-Domagrozumab-FL-HEK293 cells were stained with Domagrozumab (anti-GDF8) (Ab175511) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC₅₀ is 36.63 μg/mL.
Domagrozumab (anti-GDF8) (Ab175511) - SEC
The purity of Domagrozumab (anti-GDF8) (Ab175511) is more than 95% verified by HPLC.
Domagrozumab (anti-GDF8) (Ab175511) - ELISA
Immobilized Recombinant human GDF8/Myostatin protein (rp156335) at 1.0 μg/mL can bind Domagrozumab (anti-GDF8) (Ab175511) with the EC50 of 33.4 ng/mL.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab175511 | |
| 分析证书 | Ab175511 | |
| 分析证书 | Ab175511 | |
| 分析证书 | Ab175511 | |
| 分析证书 | Ab175511 | |
| 分析证书 | Ab175511 |
¥419.90
¥669.90
¥419.90
¥503.92
| 1. Bogdanovich S, Krag TO, Barton ER, Morris LD, Whittemore LA, Ahima RS, Khurana TS. (2002) Functional improvement of dystrophic muscle by myostatin blockade.. Nature, 420 (6914): (418-21). [PMID:12459784] |