货号 (SKU)

包装规格

是否现货

价格

数量

Ab175688-100μg

100μg

现货

Ab175688-1mg

1mg

现货

Ab175688-5mg

5mg

现货

Ab175688-10mg

10mg

期货

基本信息

产品名称	Trevogrumab (anti-GDF8), 生长/分化因子 8 抑制剂
别名	曲戈卢单抗 \| Trevogrumab（抗 GDF8）
英文别名	GDF 8 antibodyGDF-8 antibody \| GDF8 antibody \| GDF8_HUMAN antibody \| Growth differentiation factor 8 antibody \| Growth/differentiation factor 8 antibody \| MSLHP antibody \| MSTN antibody \| Myostatin antibody \| OTTHUMP00000163498 antibody \| GDF8 \| GDF-8 \| G
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	MSTN
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	生长/分化因子 8 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	144.04 kDa
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1429201-24-0
分子类型	抗体

关联靶点（人）

MSTN Tclin 生长/分化因子 8(Growth/differentiation factor 8) (0 活性数据)

点击查看靶蛋白信息： MSTN

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

SEC: Trevogrumab (anti-GDF8) (Ab175688)

Trevogrumab (anti-GDF8) (Ab175688) - SEC
The purity of Trevogrumab (anti-GDF8) (Ab175688) is more than 95% verified by HPLC.

ELISA: Trevogrumab (anti-GDF8) (Ab175688)

Trevogrumab (anti-GDF8) (Ab175688) - ELISA
Immobilized Recombinant Human GDF8 Protein (rp156335) at 2.0 μg/mL can bind Trevogrumab (anti-GDF8) (Ab175688) with the EC50 of 243.1 ng/mL.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0404287	分析证书	Ab175688
ZJ24F0404286	分析证书	Ab175688
ZJ24F0404285	分析证书	Ab175688

可替换产品

引用文献

1. Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J et al.. (2015) Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.. Skelet Muscle, 5 (34). [PMID:26457176]
2. Ma JD, Heavey SF, Revta C, Roeland EJ. (2014) Novel investigational biologics for the treatment of cancer cachexia.. Expert Opin Biol Ther, 14 (8): (1113-20). [PMID:24707881]
3. Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, Yakushiji F, Nishimatsu S, Ohsawa Y, Itoh F, Negishi Y, Sunada Y, Hayashi Y.. (2015) Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition.. J Med Chem, 58 (3): (1544-1549). [PMID:25569186] [10.1021/jm501170d]
4. Zhu J, Mishra RK, Schiltz GE, Makanji Y, Scheidt KA, Mazar AP, Woodruff TK.. (2015) Virtual High-Throughput Screening To Identify Novel Activin Antagonists.. J Med Chem, 58 (14): (5637-5648). [PMID:26098096] [10.1021/acs.jmedchem.5b00753]
5. Asari T, Takayama K, Nakamura A, Shimada T, Taguchi A, Hayashi Y.. (2017) Structural Basis for the Effective Myostatin Inhibition of the Mouse Myostatin Prodomain-Derived Minimum Peptide.. ACS Med Chem Lett, 8 (1): (113-117). [PMID:28105285] [10.1021/acsmedchemlett.6b00420]
6. Rentier C, Takayama K, Saitoh M, Nakamura A, Ikeyama H, Taguchi A, Taniguchi A, Hayashi Y.. (2019) Design and synthesis of potent myostatin inhibitory cyclic peptides.. Bioorg Med Chem, 27 (7): (1437-1443). [PMID:30777663] [10.1016/j.bmc.2019.02.019]
7. McPherron, A C AC and Lee, S J SJ.. (1997) Double muscling in cattle due to mutations in the myostatin gene.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:9356471]
8. Gonzalez-Cadavid, N F NF and 12 more authors.. (1998) Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.. Proceedings of the National Academy of Sciences of the United States of America, (8): [PMID:9843994]
9. Hill, Jennifer J JJ, Qiu, Yongchang Y, Hewick, Rodney M RM and Wolfman, Neil M NM.. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.. Molecular endocrinology (Baltimore, Md.), [PMID:12595574]
10. Schuelke, Markus M and 8 more authors.. (2004) Myostatin mutation associated with gross muscle hypertrophy in a child.. The New England journal of medicine, (24): [PMID:15215484]
11. Saunders, Matthew A MA and 5 more authors.. (2006) Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth.. American journal of human genetics, [PMID:17186467]
12. Takehara-Kasamatsu, Yuka Y and 11 more authors.. (2007) Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development.. The journal of medical investigation : JMI, [PMID:17878677]
13. Apgar, James R JR and 13 more authors.. (2016) Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.. mAbs, [PMID:27625211]
14. Walker, Ryan G RG and 16 more authors.. (2017) Structural basis for potency differences between GDF8 and GDF11.. BMC biology, (3): [PMID:28257634]

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体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Trevogrumab (anti-GDF8), 生长/分化因子 8 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Trevogrumab (anti-GDF8), 生长/分化因子 8 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器