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Belimumab (anti-TNFSF13B), 肿瘤坏死因子配体超家族成员 13B 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170933-100μg
100μg 现货 Stock Image
Ab170933-1mg
1mg 现货 Stock Image
Ab170933-5mg
5mg 现货 Stock Image
Ab170933-10mg
10mg 期货 Stock Image

基本信息

产品名称 Belimumab (anti-TNFSF13B), 肿瘤坏死因子配体超家族成员 13B 抑制剂
别名 贝利木单抗 | 贝利木单抗(抗 TNFSF13B)
英文别名 ApoL related ligand TALL 1 antibody | B cell Activating Factor antibody | B lymphocyte stimulator antibody | B-cell-activating factor antibody | BAFF antibody | BLyS antibody | CD 257 antibody | CD257 antibody | CD257 antigen antibody | Delta BAFF antibod
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 TNFSF13B
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 抑制剂
作用机制 肿瘤坏死因子配体超家族成员 13B 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 lambdaC2
SDS-PAGE 28.2 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 175.9 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-AC, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 356547-88-1
分子类型 抗体

关联靶点(人)

TNFSF13B Tclin 肿瘤坏死因子配体超家族成员 13B(Tumor necrosis factor ligand superfamily member 13B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Belimumab (anti-TNFSF13B) (Ab170933) - SEC
The purity of Belimumab (anti-TNFSF13B) (Ab170933) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到5个结果

批号(Lot Number) 证书类型 货号
ZJ23F1001437 分析证书 Ab170933
ZJ23F1001436 分析证书 Ab170933
ZJ24F0911502 分析证书 Ab170933
ZJ24F0911503 分析证书 Ab170933
ZJ24F0911504 分析证书 Ab170933

引用文献

1. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H et al..  (1999)  BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth..  J Exp Med,  189  (11): (1747-56).  [PMID:10359578]
2. Shu, H B HB, Hu, W H WH and Johnson, H H..  (1999)  TALL-1 is a novel member of the TNF family that is down-regulated by mitogens..  Journal of leukocyte biology,  [PMID:10331498]
3. Moore, P A PA and 21 more authors..  (1999)  BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator..  Science (New York, N.Y.),  (9): [PMID:10398604]
4. Yu, G G and 16 more authors..  (2000)  APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity..  Nature immunology,  [PMID:10973284]
5. Karpusas, Michael M and 7 more authors..  (2002)  Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes..  Journal of molecular biology,  (1): [PMID:11827482]
6. Liu, Yingfang Y and 5 more authors..  (2002)  Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands..  Cell,  (8): [PMID:11853672]
7. Gavin, Amanda L AL, Aït-Azzouzene, Djemel D, Ware, Carl F CF and Nemazee, David D..  (2003)  DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF..  The Journal of biological chemistry,  (3): [PMID:12867412]
8. Dunham, A A and 125 more authors..  (2004)  The DNA sequence and analysis of human chromosome 13..  Nature,  (1): [PMID:15057823]
9. Lahiri, Ayan A and 6 more authors..  (2012)  The complexity of the BAFF TNF-family members: implications for autoimmunity..  Journal of autoimmunity,  [PMID:22749832]

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