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Tabalumab (anti-BAFF), 肿瘤坏死因子配体超家族成员 13B 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG4SP
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175663-100μg
100μg 现货 Stock Image
Ab175663-1mg
1mg 现货 Stock Image
Ab175663-5mg
5mg 现货 Stock Image
Ab175663-10mg
10mg 期货 Stock Image

基本信息

产品名称 Tabalumab (anti-BAFF), 肿瘤坏死因子配体超家族成员 13B 抑制剂
别名 他贝芦单抗 | 他巴鲁单抗(抗BAFF)
英文别名 ApoL related ligand TALL 1 antibody | B cell Activating Factor antibody | B lymphocyte stimulator antibody | B-cell-activating factor antibody | BAFF antibody | BLyS antibody | CD 257 antibody | CD257 antibody | CD257 antigen antibody | Delta BAFF antibod
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 TNFSF13B
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 抑制剂
作用机制 肿瘤坏死因子配体超家族成员 13B 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4SP
轻链亚型 kappa
SDS-PAGE 27.6 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 177.2 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1143503-67-6
分子类型 抗体

关联靶点(人)

TNFSF13B Tclin 肿瘤坏死因子配体超家族成员 13B(Tumor necrosis factor ligand superfamily member 13B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Tabalumab (anti-BAFF) (Ab175663) - SEC
The purity of Tabalumab (anti-BAFF) (Ab175663) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1114590 分析证书 Ab175663
ZJ24F1114589 分析证书 Ab175663
ZJ24F1114588 分析证书 Ab175663
ZJ24F0707790 分析证书 Ab175663
ZJ24F0707789 分析证书 Ab175663
ZJ24F0707788 分析证书 Ab175663

引用文献

1. Chugh PK.  (2012)  Lupus: novel therapies in clinical development..  Eur J Intern Med,  23  (3): (212-8).  [PMID:22385876]
2. Kreuzaler M, Rauch M, Salzer U, Birmelin J, Rizzi M, Grimbacher B, Plebani A, Lougaris V, Quinti I, Thon V et al..  (2012)  Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors..  J Immunol,  188  (1): (497-503).  [PMID:22124120]
3. Iida S, Ogiya D, Abe Y, Taniwaki M, Asou H, Maeda K, Uenaka K, Nagaoka S, Ishiki T, Conti I et al..  (2016)  Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma..  Cancer Sci,  107  (9): (1281-9).  [PMID:27350068]
4. Tanaka Y, Takeuchi T, Akashi N, Takita Y, Kovacs B, Kariyasu S.  (2017)  Efficacy and safety of tabalumab plus standard of care in Japanese patients with active systemic lupus erythematosus: Subgroup analyses of the ILLUMINATE-1 study..  Mod Rheumatol,  27  (2): (284-291).  [PMID:27471815]
5. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H et al..  (1999)  BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth..  J Exp Med,  189  (11): (1747-56).  [PMID:10359578]
6. Shu, H B HB, Hu, W H WH and Johnson, H H..  (1999)  TALL-1 is a novel member of the TNF family that is down-regulated by mitogens..  Journal of leukocyte biology,  [PMID:10331498]
7. Moore, P A PA and 21 more authors..  (1999)  BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator..  Science (New York, N.Y.),  (9): [PMID:10398604]
8. Yu, G G and 16 more authors..  (2000)  APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity..  Nature immunology,  [PMID:10973284]
9. Karpusas, Michael M and 7 more authors..  (2002)  Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes..  Journal of molecular biology,  (1): [PMID:11827482]
10. Liu, Yingfang Y and 5 more authors..  (2002)  Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands..  Cell,  (8): [PMID:11853672]
11. Gavin, Amanda L AL, Aït-Azzouzene, Djemel D, Ware, Carl F CF and Nemazee, David D..  (2003)  DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF..  The Journal of biological chemistry,  (3): [PMID:12867412]
12. Lahiri, Ayan A and 6 more authors..  (2012)  The complexity of the BAFF TNF-family members: implications for autoimmunity..  Journal of autoimmunity,  [PMID:22749832]

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