计算溶液所需的质量、体积或浓度。
This is a demo store. No orders will be fulfilled.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175663-100μg |
100μg |
现货 ![]() |
| |
| Ab175663-1mg |
1mg |
现货 ![]() |
| |
| Ab175663-5mg |
5mg |
现货 ![]() |
| |
| Ab175663-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Tabalumab (anti-BAFF), 肿瘤坏死因子配体超家族成员 13B 抑制剂 |
|---|---|
| 别名 | 他贝芦单抗 | 他巴鲁单抗(抗BAFF) |
| 英文别名 | ApoL related ligand TALL 1 antibody | B cell Activating Factor antibody | B lymphocyte stimulator antibody | B-cell-activating factor antibody | BAFF antibody | BLyS antibody | CD 257 antibody | CD257 antibody | CD257 antigen antibody | Delta BAFF antibod |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | TNFSF13B |
| 种属反应性 | 人(Human),小鼠(Mouse) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 肿瘤坏死因子配体超家族成员 13B 抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.6 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 177.2 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1143503-67-6 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Tabalumab (anti-BAFF) (Ab175663) - SEC
The purity of Tabalumab (anti-BAFF) (Ab175663) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab175663 | |
| 分析证书 | Ab175663 | |
| 分析证书 | Ab175663 | |
| 分析证书 | Ab175663 | |
| 分析证书 | Ab175663 | |
| 分析证书 | Ab175663 |
¥79.92
| 1. Chugh PK. (2012) Lupus: novel therapies in clinical development.. Eur J Intern Med, 23 (3): (212-8). [PMID:22385876] |
| 2. Kreuzaler M, Rauch M, Salzer U, Birmelin J, Rizzi M, Grimbacher B, Plebani A, Lougaris V, Quinti I, Thon V et al.. (2012) Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.. J Immunol, 188 (1): (497-503). [PMID:22124120] |
| 3. Iida S, Ogiya D, Abe Y, Taniwaki M, Asou H, Maeda K, Uenaka K, Nagaoka S, Ishiki T, Conti I et al.. (2016) Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma.. Cancer Sci, 107 (9): (1281-9). [PMID:27350068] |
| 4. Tanaka Y, Takeuchi T, Akashi N, Takita Y, Kovacs B, Kariyasu S. (2017) Efficacy and safety of tabalumab plus standard of care in Japanese patients with active systemic lupus erythematosus: Subgroup analyses of the ILLUMINATE-1 study.. Mod Rheumatol, 27 (2): (284-291). [PMID:27471815] |
| 5. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H et al.. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.. J Exp Med, 189 (11): (1747-56). [PMID:10359578] |
| 6. Shu, H B HB, Hu, W H WH and Johnson, H H.. (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.. Journal of leukocyte biology, [PMID:10331498] |
| 7. Moore, P A PA and 21 more authors.. (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.. Science (New York, N.Y.), (9): [PMID:10398604] |
| 8. Yu, G G and 16 more authors.. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.. Nature immunology, [PMID:10973284] |
| 9. Karpusas, Michael M and 7 more authors.. (2002) Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes.. Journal of molecular biology, (1): [PMID:11827482] |
| 10. Liu, Yingfang Y and 5 more authors.. (2002) Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.. Cell, (8): [PMID:11853672] |
| 11. Gavin, Amanda L AL, Aït-Azzouzene, Djemel D, Ware, Carl F CF and Nemazee, David D.. (2003) DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF.. The Journal of biological chemistry, (3): [PMID:12867412] |
| 12. Lahiri, Ayan A and 6 more authors.. (2012) The complexity of the BAFF TNF-family members: implications for autoimmunity.. Journal of autoimmunity, [PMID:22749832] |