Bcl-XL Mouse mAb

COA

级别和纯度:

≥95%(SDS-PAGE)
0.5 mg/mL

应用:

ELISA
Flow Cytometry

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: IJ02/2C6
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab156202-10μl	10μl	现货
Ab156202-50μl	50μL	现货
Ab156202-100μl	100μL	现货
Ab156202-1ml	1ml	期货

查看相关系列

点击查看靶蛋白信息: BCL2L1

Accession#:Q07817 (4) Bcl-XL (4) BCL2L1 (4) Gene ID:598 (4)

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基本信息

产品名称	Bcl-XL Mouse mAb
别名	抗凋亡抑制基因BCL-XL抗体；Bcl-XL 小鼠单克隆抗体 \| Anti-Bcl-XL抗体 \| Bcl-XL小鼠单克隆抗体 \| Bcl-XL小鼠单抗 \| B细胞超大淋巴瘤 \| Bcl-XL抗体 \| 小鼠抗人Bcl-XL单克隆抗体
英文别名	Apoptosis regulator Bcl X antibody \| Apoptosis regulator Bcl-X antibody \| Apoptosis regulator BclX antibody \| B cell lymphoma 2 like antibody \| B2CL1_HUMAN antibody \| Bcl 2 like 1 protein antibody \| Bcl X antibody \| Bcl xL antibody \| BCL XL/S antibody \| B
规格或纯度	无载体, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 0.5 mg/mL
生化机理	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis.
宿主种属	小鼠(Mouse)
特异性	Human Bcl-XL
种属反应性	人(Human)
免疫原	Recombinant protein corresponding to human Bcl-XL
阳性对照	Flow Cytometry: Jurkat cells
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	AB04/4D7
Format	Whole IgG
亚型	IgG2b
轻链亚型	kappa
SDS-PAGE	150.0 KDa
纯化方法	Protein A purified
物理外观	Liquid
储存缓冲液	PBS, pH 7.4
浓度	0.5 mg/mL
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.
分子类型	抗体

关联靶点（人）

BCL2L1 Tchem Bcl-2类蛋白1(Bcl-2-like protein 1) (0 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

BCL2L1 Tchem Apoptosis regulator Bcl-X (2604 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Bcl-xL/BAK (60 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Bcl-xL/BH3-interacting domain death agonist (15 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Bcl-xL/BAX (4 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Bcl-xL/Bcl-2-like protein 11 (53 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Bcl-xL/Bcl-2-binding component 3 (27 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BCL2L1 Tchem Protein cereblon/Bcl-2-like protein 1 (8 活性数据)

点击查看靶蛋白信息： BCL2L1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Bcl-XL Mouse mAb (Ab156202)

Bcl-XL Mouse mAb (Ab156202) - Flow Cytometry 
Overlay histogram showing Jurkat cells stained with Bcl-XL Mouse mAb (Ab156202) (Red) at 1.25 μg/mL for 1 hour at 4°C. The Goat Anti-Mouse IgG H&L (PE) (Ab179006) was used as the secondary antibody. Unlabeled sample (Black) was used as a negative control. Mouse IgG1-kappa, anti-E8L (Ab213557) was used as an isotype control (Blue).