IL-6 Mouse mAb

COA

级别和纯度:

见COA

应用:

CLIA
Detection Antibody
ELISA
GICA

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG
克隆号: 16F5
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab110379-10μg	10μg	现货
Ab110379-50μg	50μg	现货
Ab110379-100μg	100μg	现货
Ab110379-1mg	1mg	期货

查看相关系列

点击查看靶蛋白信息: IL6

Accession#:P05231 (23) Gene ID:3569 (23) IL6 (25)

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基本信息

产品名称	IL-6 Mouse mAb
别名	白介素6单克隆抗体 \| IL-6鼠单抗 \| IL6抗体 \| IL-6 小鼠单克隆抗体 \| IL-6 小鼠单抗
英文别名	B-cell differentiation factor \| B-cell stimulatory factor 2 \| BSF2 \| BSF-2 \| CDF \| CTL differentiation factor \| HSF \| hybridoma growth factor \| IFNB2 \| IFN-beta-2 \| IL6 \| IL-6 \| Interferon beta-2 \| interleukin 6 (interferon, beta 2) \| interleukin BSF-2 \|
规格或纯度	无载体, ExactAb™, 无叠氮钠, 已验证, 见COA
宿主种属	小鼠(Mouse)
特异性	IL6
应用	CLIA,GICA,Detection antibody
种属反应性	人(Human)
免疫原	E. coli-derived recombinant human IL-6.
偶联	Unconjugated

产品属性

抗体类型	Primary antibody
克隆类型	单克隆抗体
克隆号	16F5
Format	Whole IgG
SDS-PAGE	150 kDa
纯化方法	Protein A purified
配对抗体	[Ab110369] Monoclonal IL-6 Antibody as Capture antibody in CLIA, GICA
来源	Hybridoma supernatant
物理外观	Liquid
储存缓冲液	10mMPB+150mM NaCl+0.1% Proclin 300, pH7.4
防腐剂	0.1% Proclin 300
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	储存：-20℃ 长期储存。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

IL6 Tclin 白细胞介素-6(Interleukin-6) (0 活性数据)

点击查看靶蛋白信息： IL6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Binding ELISA: IL-6 Mouse mAb (Ab110379)

IL-6 Mouse mAb (Ab110379) - Binding ELISA
The binding activity of IL-6 Mouse mAb with IL-6 antigen.

应用

应用名称	稀释比例
GICA	2.0 mg/mL
CLIA	2.0 mg/mL

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	货号
ZJ24F1011948	分析证书	Ab110379
ZJ23F0700661	分析证书	Ab110379

技术文档和文章

酶联免疫斑点技术（ELISPOT）实验方案

Categories: 实验方案（Protocols）

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细胞因子生长因子酶联免疫斑点技术分泌蛋白辣根过氧化物酶偶联二抗

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引用文献

1. Boulanger MJ, Chow DC, Brevnova EE, Garcia KC. (2003) Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.. Science, 300 (5628): (2101-4). [PMID:12829785]
2. Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S et al.. (2014) Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.. MAbs, 6 (3): (774-82). [PMID:24670876]
3. Kang S, Tanaka T, Narazaki M, Kishimoto T. (2019) Targeting Interleukin-6 Signaling in Clinic.. Immunity, 50 (4): (1007-1023). [PMID:30995492] [10.1016/j.immuni.2019.03.026]
4. Q Y Chen. (1992-09-01) [Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer].. Zhonghua zhong liu za zhi [Chinese journal of oncology], 14 ((5)): (340-344). [PMID:1291290]
5. H C van Zaanen,R P Koopmans,L A Aarden,H J Rensink,J M Stouthard,S O Warnaar,H M Lokhorst,M H van Oers. (1996-09-15) Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.. The Journal of clinical investigation, 98 ((6)): (1441-1448). [PMID:8823310]
6. Kim D, Won HY, Hwang ES, Kim YK, Choo HP.. (2017) Synthesis of benzoxazole derivatives as interleukin-6 antagonists.. Bioorg Med Chem, 25 (12): (3127-3134). [PMID:28442260] [10.1016/j.bmc.2017.03.072]
7. May, L T LT, Shaw, J E JE, Khanna, A K AK, Zabriskie, J B JB and Sehgal, P B PB.. (1991) Marked cell-type-specific differences in glycosylation of human interleukin-6.. Cytokine, [PMID:1883960]
8. Lütticken, C C, Krüttgen, A A, Möller, C C, Heinrich, P C PC and Rose-John, S S.. (1991) Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.. FEBS letters, (6): [PMID:2037043]
9. Clogston, C L CL, Boone, T C TC, Crandall, B C BC, Mendiaz, E A EA and Lu, H S HS.. (1989) Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.. Archives of biochemistry and biophysics, [PMID:2472117]
10. Ming, J E JE, Cernetti, C C, Steinman, R M RM and Granelli-Piperno, A A.. (1989) Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.. The Journal of molecular and cellular immunology : JMCI, [PMID:2610854]
11. Tonouchi, N N, Miwa, K K, Karasuyama, H H and Matsui, H H.. (1989) Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells.. Biochemical and biophysical research communications, (15): [PMID:2789513]
12. Zilberstein, A A, Ruggieri, R R, Korn, J H JH and Revel, M M.. (1986) Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.. The EMBO journal, [PMID:3023045]
13. Wong, G G GG, Witek-Giannotti, J J, Hewick, R M RM, Clark, S C SC and Ogawa, M M.. (1988) Interleukin 6: identification as a hematopoietic colony-stimulating factor.. Behring Institute Mitteilungen, [PMID:3266463]
14. Van Damme, J J and 5 more authors.. (1988) Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:3279116]
15. Brakenhoff, J P JP, de Groot, E R ER, Evers, R F RF, Pannekoek, H H and Aarden, L A LA.. (1987) Molecular cloning and expression of hybridoma growth factor in Escherichia coli.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:3320204]
16. Hirano, T T and 9 more authors.. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.. Nature, [PMID:3491322]
17. Yasukawa, K K and 6 more authors.. (1987) Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.. The EMBO journal, [PMID:3500852]
18. May, L T LT, Helfgott, D C DC and Sehgal, P B PB.. (1986) Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3538015]
19. Haegeman, G G and 5 more authors.. (1986) Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.. European journal of biochemistry, (15): [PMID:3758081]
20. Breton, J J and 8 more authors.. (1995) Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.. European journal of biochemistry, (15): [PMID:7851440]
21. Nishimura, C C, Watanabe, A A, Gouda, H H, Shimada, I I and Arata, Y Y.. (1996) Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy.. Biochemistry, (9): [PMID:8555185]
22. Somers, W W, Stahl, M M and Seehra, J S JS.. (1997) 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.. The EMBO journal, (3): [PMID:9118960]
23. Xu, G Y GY and 6 more authors.. (1997) Solution structure of recombinant human interleukin-6.. Journal of molecular biology, (2): [PMID:9159484]
24. Fishman, D D and 6 more authors.. (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.. The Journal of clinical investigation, (1): [PMID:9769329]
25. Foster, C B CB and 11 more authors.. (2000) An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.. Blood, (1): [PMID:11001912]
26. Ota, N N and 8 more authors.. (2001) A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.. Journal of human genetics, [PMID:11355017]
27. Chung, Hye Won HW and 8 more authors.. (2003) Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.. Journal of human genetics, [PMID:12768442]
28. Nakahara, Hideko H and 6 more authors.. (2003) Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.. Arthritis and rheumatism, [PMID:12794819]
29. Nemeth, Elizabeta E and 6 more authors.. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.. The Journal of clinical investigation, [PMID:15124018]
30. Wolsk, Emil E, Mygind, Helene H, Grøndahl, Thomas S TS, Pedersen, Bente K BK and van Hall, Gerrit G.. (2010) IL-6 selectively stimulates fat metabolism in human skeletal muscle.. American journal of physiology. Endocrinology and metabolism, [PMID:20823453]
31. Ellingsgaard, Helga H and 20 more authors.. (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.. Nature medicine, (30): [PMID:22037645]
32. Taniguchi, Koji K and 17 more authors.. (2015) A gp130-Src-YAP module links inflammation to epithelial regeneration.. Nature, (5): [PMID:25731159]
33. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]
34. Larsen, Jakob Vejby JV and Petersen, Claus Munck CM.. (2017) SorLA in Interleukin-6 Signaling and Turnover.. Molecular and cellular biology, (1): [PMID:28265003]

溶液计算器

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计算溶液所需的质量、体积或浓度。

质量

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体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

IL-6 Mouse mAb

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器