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GNB1 Antibody

    应用:
  • IHC
  • WB
  • 宿主种属: 兔(Rabbit)
  • 种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse)
  • 亚型: Rabbit IgG
  • 偶联: Unconjugated
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab105938-10μl
10μl 期货 Stock Image
Ab105938-50μl
50μL 现货 Stock Image
Ab105938-100μl
100μL 现货 Stock Image
Ab105938-1ml
1ml 期货 Stock Image

基本信息

产品名称 GNB1 Antibody
别名 G蛋白/鸟苷酸结合蛋白抗体 | GNB1抗体 | GNB1多抗 | GNB1抗体
英文别名 G protein beta subunit GI/GS/GT | guanine nucleotide binding protein (G protein), beta polypeptide 1 | guanine nucleotide-binding protein G | GBB1_HUMAN | Beta subunit signal transducing proteins GS/GI antibody | G protein beta 1 subunit antibody | GBB1 a
规格或纯度 ExactAb™, Validated, Carrier Free, 0.2 mg/mL
宿主种属 兔(Rabbit)
特异性 GNB1
种属反应性 人(Human),大鼠(Rat),小鼠(Mouse)
免疫原 Fusion protein of human GNB1 (AA 100-340).
阳性对照 WB: Hep G2, A549, HEK293, Jurkat, HeLa, Raji, NIH/3T3 and C6 cell lysates. IHC: Human liver cancer tissue.
偶联 Unconjugated

产品属性

克隆类型 多克隆抗体
Format Whole IgG
亚型 Rabbit IgG
SDS-PAGE 150 kDa
纯化方法 Protein A purified
物理外观 Liquid
储存缓冲液 10mM PBS, 40% Glycerol, 0.05% Sodium azide, pH 7.4
防腐剂 0.05% Sodium azide
浓度 0.2 mg/mL
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 4°C 短期储存(1-2 周)。-20°C下长期保存(24个月)。收货后建议分装。避免冷冻/解冻循环。
分子类型 抗体

关联靶点(人)

GNB1 Tbio 鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1(Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

GNB1 Antibody (Ab105938) - Western Blot
All lanes: GNB1 Antibody (Ab105938) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 37 kDa
Observed band size: 35 kDa
Exposure time: 60.0 s

GNB1 Antibody (Ab105938) - IHC
Immunohistochemistry analysis of paraffin-embedded Human liver cancer using GNB1 Antibody (Ab105938). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

应用

应用名称 稀释比例
WB

1/500-1/1000

IHC

1/50 - 1/100

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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找到2个结果

批号(Lot Number) 证书类型 货号
ZJ23F1202121 分析证书 Ab105938
ZJ23F1202122 分析证书 Ab105938

引用文献

1. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed.  (2009-05-06)  Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach..  Analytical chemistry,  81  ((11)): (4493-4501).  [PMID:19413330]
2. Codina, J J, Stengel, D D, Woo, S L SL and Birnbaumer, L L..  (1986)  Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical..  FEBS letters,  (27): [PMID:3095147]
3. Niu, Jiaxin J, Profirovic, Jasmina J, Pan, Haiyun H, Vaiskunaite, Rita R and Voyno-Yasenetskaya, Tatyana T..  (2003)  G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production..  Circulation research,  (31): [PMID:14512443]
4. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,  (18): [PMID:16710414]
5. Hill, Claire C, Goddard, Alan A, Ladds, Graham G and Davey, John J..  (2009)  The cationic region of Rhes mediates its interactions with specific Gbeta subunits..  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,  [PMID:19255495]
6. Wang, Zhenglong Z and 9 more authors..  (2009)  Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5..  The Journal of biological chemistry,  (16): [PMID:19713215]
7. Bienvenut, Willy V WV and 6 more authors..  (2012)  Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features..  Molecular & cellular proteomics : MCP,  [PMID:22223895]
8. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,  (4): [PMID:23186163]
9. Yoda, Akinori A and 28 more authors..  (2015)  Mutations in G protein β subunits promote transformation and kinase inhibitor resistance..  Nature medicine,  [PMID:25485910]
10. Petrovski, Slavé S and 46 more authors..  (2016)  Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures..  American journal of human genetics,  (5): [PMID:27108799]
11. Steinrücke, Sofia S and 7 more authors..  (2016)  Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability..  Neurology. Genetics,  [PMID:27668284]
12. Lohmann, Katja K and 17 more authors..  (2017)  Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans..  Human molecular genetics,  (15): [PMID:28087732]
13. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge.  (2011-01-29)  Initial characterization of the human central proteome..  BMC systems biology,  (17-17).  [PMID:21269460]

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