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| SKU | Size | Availability |
Price | Qty |
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Ab191932-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$59.90
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Ab191932-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$289.90
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Ab191932-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$749.90
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Ab191932-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,189.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Xeligekimab (anti-IL-17A) - Primary antibody, specific to IL17A, Human IgG4SP |
|---|---|
| Synonyms | CTLA 8 antibody | CTLA-8 antibody | CTLA8 antibody | cytotoxic T lymphocyte associated antigen 8 antibody | Cytotoxic T lymphocyte associated protein 8 antibody | Cytotoxic T lymphocyte associated serine esterase 8 antibody | Cytotoxic T-lymphocyte-associ |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. Post-translational: Found both in glycosylated and nonglycosylated forms. |
| Host species | Human |
| Specificity | IL17A |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Xeligekimab (anti-IL-17A) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab (anti-IL-17A) inhibits the pro-inflammatory cascade.
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| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 147.34 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2382921-73-3 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Xeligekimab (anti-IL-17A) (Ab191932) - ELISA
Immobilized Recombinant Human CTLA-8 / IL-17a protein at 2.0 μg/mL can bind Xeligekimab (anti-IL-17A) (Ab191932) with the EC₅₀ of 21.82 ng/mL.
Xeligekimab (anti-IL-17A) (Ab191932) - SEC
The purity of Xeligekimab (anti-IL-17A) (Ab191932) is more than 95% verified by HPLC.
Starting at $109.90
Starting at $59.90
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Starting at $109.90