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Netakimab (anti-IL-17A) - Primary antibody, specific to IL17A, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab191931
Grouped product items
SKU Size
Availability
Price Qty
Ab191931-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab191931-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab191931-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90
Ab191931-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level <0.01EU/μg ; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Netakimab (anti-IL-17A) - Primary antibody, specific to IL17A, Human IgG1
Synonyms CTLA 8 antibody | CTLA-8 antibody | CTLA8 antibody | cytotoxic T lymphocyte associated antigen 8 antibody | Cytotoxic T lymphocyte associated protein 8 antibody | Cytotoxic T lymphocyte associated serine esterase 8 antibody | Cytotoxic T-lymphocyte-associ
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC)
Biochemical and Physiological Mechanisms Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. Post-translational: Found both in glycosylated and nonglycosylated forms.
Host species Human
Specificity IL17A
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Netakimab (anti-IL-17A) is an anti-IL-17 monoclonal antibody. Netakimab (anti-IL-17A) can be used for research of ankylosing spondylitis, psoriatic arthritis, moderate-to-severe plaque psoriasis.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1796570-08-5

Associated Targets(Human)

IL17A Tclin Interleukin-17A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Netakimab (anti-IL-17A) (Ab191931) - ELISA
Immobilized Recombinant Human CTLA-8 / IL-17a protein at 2.0 μg/mL can bind Netakimab (anti-IL-17A) (Ab191931) with the EC50 of 14.02 ng/mL.

Netakimab (anti-IL-17A) (Ab191931) - SEC
The purity of Netakimab (anti-IL-17A) (Ab191931) is more than 95% verified by HPLC.

Netakimab (anti-IL-17A) (Ab191931) - ELISA
Immobilized Recombinant Human IL-17A protein (rp169639) at 2.0 μg/mL can bind Netakimab (anti-IL-17A) (Ab191931) with the EC₅₀ of 21.7 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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