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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab191931-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab191931-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$519.90
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Ab191931-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,299.90
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Ab191931-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,079.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level <0.01EU/μg ; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Netakimab (anti-IL-17A) - Primary antibody, specific to IL17A, Human IgG1 |
|---|---|
| Synonyms | CTLA 8 antibody | CTLA-8 antibody | CTLA8 antibody | cytotoxic T lymphocyte associated antigen 8 antibody | Cytotoxic T lymphocyte associated protein 8 antibody | Cytotoxic T lymphocyte associated serine esterase 8 antibody | Cytotoxic T-lymphocyte-associ |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC) |
| Biochemical and Physiological Mechanisms | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. Post-translational: Found both in glycosylated and nonglycosylated forms. |
| Host species | Human |
| Specificity | IL17A |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Netakimab (anti-IL-17A) is an anti-IL-17 monoclonal antibody. Netakimab (anti-IL-17A) can be used for research of ankylosing spondylitis, psoriatic arthritis, moderate-to-severe plaque psoriasis.
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| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1796570-08-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Netakimab (anti-IL-17A) (Ab191931) - ELISA
Immobilized Recombinant Human CTLA-8 / IL-17a protein at 2.0 μg/mL can bind Netakimab (anti-IL-17A) (Ab191931) with the EC50 of 14.02 ng/mL.
Netakimab (anti-IL-17A) (Ab191931) - SEC
The purity of Netakimab (anti-IL-17A) (Ab191931) is more than 95% verified by HPLC.
Netakimab (anti-IL-17A) (Ab191931) - ELISA
Immobilized Recombinant Human IL-17A protein (rp169639) at 2.0 μg/mL can bind Netakimab (anti-IL-17A) (Ab191931) with the EC₅₀ of 21.7 ng/mL.
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