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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab190139-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$49.90
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Ab190139-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$249.90
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Ab190139-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$649.90
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Ab190139-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,029.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Tucotuzumab (anti-EpCAM) - Primary antibody, specific to EPCAM, Human IgG1 |
|---|---|
| Synonyms | 17 1A antibody | 323/A3 antibody | Adenocarcinoma associated antigen antibody | Adenocarcinoma-associated antigen antibody | Antigen identified by monoclonal antibody AUA1 antibody | AUA1 antibody | CD326 antibody | CD326 antigen antibody | Cell surface g |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Pla |
| Host species | Human |
| Specificity | EPCAM |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Tucotuzumab (anti-EpCAM) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab (anti-EpCAM) links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule.
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| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 144.34 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 339986-90-2 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Tucotuzumab (anti-EpCAM) (Ab190139) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling EpCAM (red) with Tucotuzumab (anti-EpCAM) (Ab190139) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tucotuzumab (anti-EpCAM) (Ab190139) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EpCAM (red) with Tucotuzumab (anti-EpCAM) (Ab190139) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tucotuzumab (anti-EpCAM) (Ab190139) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling EpCAM (red) with Tucotuzumab (anti-EpCAM) (Ab190139) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tucotuzumab (anti-EpCAM) (Ab190139) - ELISA
Immobilized Recombinant Human EpCAM protein (rp170132) at 1.0 μg/mL can bind Tucotuzumab (anti-EpCAM) (Ab190139) with the EC50 of 33.85 ng/mL.
Tucotuzumab (anti-EpCAM) (Ab190139) - SEC
The purity of Tucotuzumab (anti-EpCAM) (Ab190139) is more than 95% verified by HPLC.
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