Grouped product items

SKU

Size

Availability

Price

Qty

T411999-100μg

100μg

$37.90

T411999-1mg

1mg

$159.90

T411999-5mg

5mg

$664.90

T411999-10mg

10mg

Available within 8-12 weeks(?)

$1,196.90

Basic Description

Product Name	Trastuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2
Synonyms	8-Aminoguanosine, >=98% (HPLC) \| SHO2CA1BRO \| Guanosine, 8-amino- \| SCHEMBL483333 \| 2,8-diamino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one \| PD183255 \| NSC 90390 \| NSC816045 \| NSC-816045 \| NSC-90390 \| BDBM50227263
Specifications & Purity	Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a
Host species	Human
Specificity	ERBB2/HER2/CD340
Application	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of erb-b2 receptor tyrosine kinase 2
Product Description	Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class Purine nucleosides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	Purine nucleosides
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Purine nucleosides
Alternative Parents	Glycosylamines 6-oxopurines Pentoses Hypoxanthines Pyrimidones Aminopyrimidines and derivatives Aminoimidazoles N-substituted imidazoles Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols Primary amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Pentose monosaccharide - Hypoxanthine - Purinone - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidone - Aminoimidazole - N-substituted imidazole - Monosaccharide - Pyrimidine - Azole - Tetrahydrofuran - Vinylogous amide - Imidazole - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Primary amine - Amine - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Source	CHO supernatant
Shape	Liquid
Concentration	See COA
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 2-8℃ short term (1-2 weeks). Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS	180288-69-1

Associated Targets(Human)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor (487 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin FASN/HER2 (2 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Images

Flow Cytometry: Trastuzumab (anti-HER2) (T411999)

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Trastuzumab (anti-HER2) (T411999)

Trastuzumab (anti-HER2) (T411999) - SEC
The purity of Trastuzumab (anti-HER2) (T411999) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
ZJ25F0319113	Certificate of Analysis	Mar 12, 2025	T411999
ZJ24F0202898	Certificate of Analysis	Mar 01, 2024	T411999
ZJ24F0202897	Certificate of Analysis	Mar 01, 2024	T411999
ZJ24F0202896	Certificate of Analysis	Mar 01, 2024	T411999

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Dongmei Li, Chaofan Weng, Chaoyi Chen, Kan Li, Qiang Lin, Yi Ruan, Yi Ruan, Jingjing Zhang, Shuqian Wang, Jia Yao, Jia Yao. (2022) Optical biosensor based on weak value amplification for the high sensitivity detection of Pertuzumab in combination with Trastuzumab binding to the extracellular domain of HER2. OPTICS EXPRESS, 30 (20): (36839-36848).

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Trastuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Alternative Products

Citations of This Product

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews

Trastuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Mechanisms of Action

Images

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Related Products

Alternative Products

Citations of This Product

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews