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Pertuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse,Rat
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
P412000
Grouped product items
SKU Size
Availability
 Price Qty
P412000-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
P412000-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$159.90
P412000-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$664.90
P412000-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,196.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: CYP1A2 Click to view target information: ERBB2 Click to view target information: ADRB2
Accession#:P04626 (13) EGFR (254) erb-b2 receptor tyrosine kinase 2 Antibody (4) ERBB2 (13) Gene ID:2064 (13) HER2 (11) JAK/STAT Signaling (507) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Product Name Pertuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2
Synonyms 2-Butanol, 1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-, [R-(R*,S*)]- | Q27078025 | (2R,3S)-3-(isopropylamino)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]butan-2-ol | DTXSID401118341 | SCHEMBL8027938 | (2R,3S)-1-[(7-methyl-2,3-dih
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ERBB2/HER2/CD340
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of erb-b2 receptor tyrosine kinase 2
Product Description

Pertuzumab, a humanized IgG1 monoclonal antibody, is a HER2 dimerization inhibitor. It can be used in the study of metastatic HER2 positive breast cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Indanes
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Indanes
Alternative Parents Alkyl aryl ethers  Secondary alcohols  1,2-aminoalcohols  Dialkylamines  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Indane - Alkyl aryl ether - 1,2-aminoalcohol - Secondary alcohol - Secondary aliphatic amine - Ether - Secondary amine - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
External Descriptors aromatic ether - secondary alcohol - secondary amino compound - indanes

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.44 kDa
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 380610-27-5

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor (487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin FASN/HER2 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Pertuzumab (anti-HER2) (P412000) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Pertuzumab (anti-HER2) (P412000). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Pertuzumab (anti-HER2) (P412000) - SEC
The purity of Pertuzumab (anti-HER2) (P412000) is more than 95% verified by HPLC.

Pertuzumab (anti-HER2) (P412000) - ELISA
Immobilized HER2-23-652-his at 2 μg/mL can bind Pertuzumab (anti-HER2) (P412000) with the EC₅₀ of 13.75 ng/mL.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
ZJ24F1215935 Certificate of Analysis Dec 24, 2024 P412000
ZJ24F1215934 Certificate of Analysis Dec 24, 2024 P412000
ZJ23F0800951 Certificate of Analysis Sep 04, 2023 P412000
ZJ23F0800952 Certificate of Analysis Sep 04, 2023 P412000

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