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Immunology/Inflammation
CD276/B7-H3
Mirzotamab (anti-CD276) - Primary antibody, specific to CD276, >95% (SDS-PAGE&SEC), high purity, Human IgG1

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Mirzotamab (anti-CD276) - Primary antibody, specific to CD276, >95% (SDS-PAGE&SEC), high purity, Human IgG1

Grade & Purity:

≥95%(SDS-PAGE&SEC-HPLC)
See COA

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Host species: Human
Reactive species: Human
Isotype: Human IgG1
Conjugation: Unconjugated

In stock

Item Number

Ab182952

Grouped product items
SKU	Size	Availability	Price	Qty
Ab182952-100μg	100μg	10	$69.90
Ab182952-1mg	1mg	4	$309.90
Ab182952-5mg	5mg	1	$809.90
Ab182952-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,299.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Click to view target information: CD276

Accession#:Q5ZPR3 (8) B7-H3 (4) CD276 (9) Gene ID:80381 (8)

Basic Description

Product Name	Mirzotamab (anti-CD276) - Primary antibody, specific to CD276, >95% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms	4Ig B7 H3 antibody \| 4Ig-B7-H3 antibody \| AU016588 antibody \| B7 H3 antibody \| B7 homolog 3 antibody \| B7-H3 antibody \| B7H3 antibody \| B7RP-2 antibody \| CD_antigen=CD276 antibody \| CD276 antibody \| CD276 antigen antibody \| CD276 molecule antibody \| CD276
Specifications & Purity	Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species	Human
Specificity	CD276
Conjugation	Unconjugated
Grade	Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description	Mirzotamab (anti-CD276) is an IgG1κ antibody targeting to CD276/B7-H3. Mirzotamab (anti-CD276) can conjugates with Clezutoclax, an BCL inhibitor to form Mirzotamab clezutoclax, involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC). Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	26.5 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 208.9 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95% (SDS-PAGE&SEC)
Shape	Liquid
Concentration	See COA
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS	2229859-11-2

Associated Targets(Human)

CD276 Tbio CD276 antigen (0 Activities)

Discover Target: CD276

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Images

Flow Cytometry: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling CD276 (red) with Mirzotamab (anti-CD276) (Ab182952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - ELISA
Immobilized Recombinant Human CD276 Protein ( rp143912) at 1.0 μg/mL can bind Mirzotamab (anti-CD276) (Ab182952) with the EC50 of 28.84 ng/mL.

Flow Cytometry: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - Flow Cytometry
Flow Cytometry analysis of U2OS cells labelling CD276 (red) with Mirzotamab (anti-CD276) (Ab182952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling CD276 (red) with Mirzotamab (anti-CD276) (Ab182952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling CD276 (red) with Mirzotamab (anti-CD276) (Ab182952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - Flow Cytometry
Flow Cytometry analysis of THP-1 cells labelling CD276 (red) with Mirzotamab (anti-CD276) (Ab182952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Mirzotamab (anti-CD276) (Ab182952)

Mirzotamab (anti-CD276) (Ab182952) - SEC
The purity of Mirzotamab (anti-CD276) (Ab182952) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505108	Certificate of Analysis	May 06, 2024	Ab182952
ZJ24F0505107	Certificate of Analysis	May 06, 2024	Ab182952
ZJ24F0505106	Certificate of Analysis	May 06, 2024	Ab182952

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