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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab190127-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$89.90
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Ab190127-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$419.90
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Ab190127-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,089.90
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Ab190127-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,749.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Lonigutamab (anti-IGF1-R) - Primary antibody, specific to IGF1R, Human IgG1 |
|---|---|
| Synonyms | CD221 antibody | CD221 antigen antibody | IGF 1 receptor antibody | IGF 1R antibody | IGF I receptor antibody | IGF-I receptor antibody | Igf1r antibody | IGF1R_HUMAN antibody | IGFIR antibody | IGFIRC antibody | IGFR antibody | Insulin like growth factor |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial f |
| Host species | Human |
| Specificity | IGF1R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Lonigutamab (anti-IGF1-R) is a humanized monoclonal antibody against the insulin-like growth factor-1 receptor (IGF-1R) with the potential to treat thyroid eye disease (TED).
|
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145.12 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Lonigutamab (anti-IGF1-R) (Ab190127) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling IGF1-R (red) with Lonigutamab (anti-IGF1-R) (Ab190127). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lonigutamab (anti-IGF1-R) (Ab190127) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling IGF1-R (red) with Lonigutamab (anti-IGF1-R) (Ab190127). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lonigutamab (anti-IGF1-R) (Ab190127) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling IGF1-R (red) with Lonigutamab (anti-IGF1-R) (Ab190127). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lonigutamab (anti-IGF1-R) (Ab190127) - SEC
The purity of Lonigutamab (anti-IGF1-R) (Ab190127) is more than 95% verified by HPLC.