Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
Ab183454-100μg
|
100μg |
10
|
$109.90
|
|
|
Ab183454-1mg
|
1mg |
4
|
$519.90
|
|
|
Ab183454-5mg
|
5mg |
1
|
$1,299.90
|
|
|
Ab183454-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,079.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Enoticumab (anti-DLL4) - Primary antibody, specific to DLL4, Human IgG1, INHIBITOR of Delta-like protein 4 inhibitor |
|---|---|
| Synonyms | AOS6 antibody | Delta 4 antibody | delta 4 precursor antibody | Delta ligand 4 antibody | delta ligand 4 precursor antibody | Delta like 4 antibody | Delta like 4 homolog antibody | Delta like 4 protein antibody | Delta like canonical Notch ligand 4 antib |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | DLL4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Delta-like protein 4 inhibitor |
| Product Description |
Enoticumab (anti-DLL4) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab (anti-DLL4) in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.4 kDa (Light Chain) & 53.7 kDa (Heavy Chain), under reducing conditions; 212.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1192578-27-0 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Enoticumab (anti-DLL4) (Ab183454) - ELISA
Immobilized Recombinant Human DLL4 Protein (rp181238) at 1.0 μg/mL can bind Enoticumab (anti-DLL4) (Ab183454) with the EC₅₀ of 19.84 ng/mL.
Enoticumab (anti-DLL4) (Ab183454) - ELISA
Immobilized HuDLL4-ECD-his at 2.0 μg/mL can bind Enoticumab (anti-DLL4) (Ab183454) with the EC₅₀ of 2.33 ng/mL.
Enoticumab (anti-DLL4) (Ab183454) - SEC
The purity of Enoticumab (anti-DLL4) (Ab183454) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 24, 2024 | Ab183454 | |
| Certificate of Analysis | Jul 24, 2024 | Ab183454 | |
| Certificate of Analysis | Jul 24, 2024 | Ab183454 |
Starting at $89.90
Starting at $129.90