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| SKU | Size | Availability |
Price | Qty |
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Ab176592-100μg
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100μg |
10
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$89.90
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Ab176592-1mg
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1mg |
4
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$429.90
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Ab176592-5mg
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5mg |
1
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$1,069.90
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Ab176592-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,769.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Demcizumab (anti-DLL4) - Primary antibody, specific to DLL4, >95%, high purity, Human IgG2SA, INHIBITOR of Delta-like protein 4 inhibitor |
|---|---|
| Synonyms | AOS6 antibody | Delta 4 antibody | delta 4 precursor antibody | Delta ligand 4 antibody | delta ligand 4 precursor antibody | Delta like 4 antibody | Delta like 4 homolog antibody | Delta like 4 protein antibody | Delta like canonical Notch ligand 4 antib |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | DLL4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Delta-like protein 4 inhibitor |
| Product Description |
Demcizumab (anti-DLL4) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab (anti-DLL4) alone or in combination with chemotherapy is effective in various cancer models. |
| Isotype | Human IgG2SA |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145.34 kDa |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1243262-17-0 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Demcizumab (anti-DLL4) (Ab176592) - ELISA
Immobilized Recombinant Human DLL4 (C-10His) is at 2.0 μg/mL can bind Demcizumab (anti-DLL4) (Ab176592) with the EC50 of 8.92 ng/mL.
Demcizumab (anti-DLL4) (Ab176592) - SEC
The purity of Demcizumab (anti-DLL4) (Ab176592) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 10, 2024 | Ab176592 | |
| Certificate of Analysis | Apr 10, 2024 | Ab176592 | |
| Certificate of Analysis | Apr 10, 2024 | Ab176592 |
Starting at $109.90
Starting at $129.90