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Demcizumab (anti-DLL4) - Primary antibody, specific to DLL4, >95%, high purity, Human IgG2SA, INHIBITOR of Delta-like protein 4 inhibitor, INHIBITOR of Delta-like protein 4 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG2SA
  • Conjugation: Unconjugated
In stock
Item Number
Ab176592
Grouped product items
SKU Size
Availability
Price Qty
Ab176592-100μg
100μg
10
$89.90
Ab176592-1mg
1mg
4
$429.90
Ab176592-5mg
5mg
1
$1,069.90
Ab176592-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,769.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Demcizumab (anti-DLL4) - Primary antibody, specific to DLL4, >95%, high purity, Human IgG2SA, INHIBITOR of Delta-like protein 4 inhibitor
Synonyms AOS6 antibody | Delta 4 antibody | delta 4 precursor antibody | Delta ligand 4 antibody | delta ligand 4 precursor antibody | Delta like 4 antibody | Delta like 4 homolog antibody | Delta like 4 protein antibody | Delta like canonical Notch ligand 4 antib
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity DLL4
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Delta-like protein 4 inhibitor
Product Description

Demcizumab (anti-DLL4) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab (anti-DLL4) alone or in combination with chemotherapy is effective in various cancer models.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG2SA
Light Chain Type kappa
SDS-PAGE 145.34 kDa
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1243262-17-0

Associated Targets(Human)

DLL4 Tbio Delta-like protein 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Demcizumab (anti-DLL4) (Ab176592) - ELISA
Immobilized Recombinant Human DLL4 (C-10His) is at 2.0 μg/mL can bind Demcizumab (anti-DLL4) (Ab176592) with the EC50 of 8.92 ng/mL.

Demcizumab (anti-DLL4) (Ab176592) - SEC
The purity of Demcizumab (anti-DLL4) (Ab176592) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404275 Certificate of Analysis Apr 10, 2024 Ab176592
ZJ24F0404274 Certificate of Analysis Apr 10, 2024 Ab176592
ZJ24F0404273 Certificate of Analysis Apr 10, 2024 Ab176592

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