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Dacetuzumab (anti-CD40) - Primary antibody, specific to CD40, Human IgG1, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab183418
Grouped product items
SKU Size
Availability
Price Qty
Ab183418-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
Ab183418-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$429.90
Ab183418-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$849.90
Ab183418-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,359.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Dacetuzumab (anti-CD40) - Primary antibody, specific to CD40, Human IgG1, INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor
Synonyms AI326936 antibody | B cell associated molecule CD40 antibody | B cell surface antigen CD40 antibody | B cell-associated molecule antibody | B-cell surface antigen CD40 antibody | Bp50 antibody | CD 40 antibody | CD40 antibody | CD40 antigen (TNF receptor
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD40
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Tumor necrosis factor receptor superfamily member 5 inhibitor
Product Description

Dacetuzumab (anti-CD40) is a humanized IgG1, anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab (anti-CD40) kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab (anti-CD40) can be used for multiple myeloma research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 880486-59-9

Associated Targets(Human)

CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Dacetuzumab (anti-CD40) (Ab183418) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Dacetuzumab (anti-CD40) (Ab183418) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Dacetuzumab (anti-CD40) (Ab183418) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Dacetuzumab (anti-CD40) (Ab183418) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Dacetuzumab (anti-CD40) (Ab183418) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Dacetuzumab (anti-CD40) (Ab183418). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Dacetuzumab (anti-CD40) (Ab183418) - ELISA
Immobilized Recombinant Human CD40 protein (rp183577) at 1.0 μg/mL can bind Dacetuzumab (anti-CD40) (Ab183418) with the EC₅₀ of 30.11 ng/mL.

Dacetuzumab (anti-CD40) (Ab183418) - SEC
The purity of Dacetuzumab (anti-CD40) (Ab183418) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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