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c-Met/HGFR

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Items 61-72 of 121

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  1. , Macrophage-stimulating protein receptor inhibitor
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    MK-8033, Macrophage-stimulating protein receptor inhibitor
    Cas Number: 1001917-37-8
    Formula:  C25H21N5O3S        Molecular Weight: 471.53
    IUPAC Name:  1-[5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide
    SMILES:  CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)CS(=O)(=O)NCC5=CC=CC=N5)N=C2
    InChIKey: VMJFTOSOFDEKTM-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2show more
    Synonyms: EX-A2612 | VMJFTOSOFDEKTM-UHFFFAOYSA-N | BDBM50427138 | 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]...
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    N'-(5-fluoro-2-oxoindolin-3-ylidene)-4-hydroxybenzohydrazide
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 330572-32-2        Compound CID:  837637
    Formula:  C15H10FN3O3        Molecular Weight: 299.2566032
    IUPAC Name:  N-[(5-fluoro-2-hydroxy-1H-indol-3-yl)imino]-4-hydroxybenzamide
    SMILES:  C1=CC(=CC=C1C(=O)N=NC2=C(NC3=C2C=C(C=C3)F)O)O
    InChIKey: NBNLEALJOLHMEO-UHFFFAOYSA-N
    InChI:  InChI=1S/C15H10FN3O3/c16-9-3-6-12-11(7-9)13(15(22)17-12)18-19-14(21)8-1-4-10(20)5-2-8/h1-7,17,20,22H
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    NPS-1034
      Grade & Purity: 
    • ≥97%
    Cas Number: 1221713-92-3
    Formula:  C31H23F2N5O3        Molecular Weight: 551.54
    IUPAC Name:  1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide
    SMILES:  CC1=C(C(=O)N(N1C)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C(=CNC5=NC=C4)C6=CC=CC=C6)F
    InChIKey: RGAZVGZUBCFHRJ-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H23F2N5O3/c1-18-27(31(40)38(37(18)2)22-11-8-20(32)9-12-22)30(39)36-21-10-13-25(24(33)16-21)41-26-14-15-34-29-28(26)23(17-35-29)19-6-4-3-5-show more
    Synonyms: N-(3-fluoro-4-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H...
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    NPS-1034
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1221713-92-3
    Formula:  C31H23F2N5O3        Molecular Weight: 551.54
    IUPAC Name:  1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide
    SMILES:  CC1=C(C(=O)N(N1C)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C(=CNC5=NC=C4)C6=CC=CC=C6)F
    InChIKey: RGAZVGZUBCFHRJ-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H23F2N5O3/c1-18-27(31(40)38(37(18)2)22-11-8-20(32)9-12-22)30(39)36-21-10-13-25(24(33)16-21)41-26-14-15-34-29-28(26)23(17-35-29)19-6-4-3-5-show more
    Synonyms: N-(3-fluoro-4-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H...
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  5. , Inhibitor of AXL receptor tyrosine kinase;Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    Ningetinib, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1394820-69-9
    Formula:  C31H29FN4O5        Molecular Weight: 556.58
    IUPAC Name:  N-[3-fluoro-4-[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide
    SMILES:  CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F
    InChIKey: VQYYQSZNRVQLIS-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39show more
    Synonyms: N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl)oxy)phenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyr...
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  6. , Inhibitor of AXL receptor tyrosine kinase;Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    Ningetinib, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1394820-69-9
    Formula:  C31H29FN4O5        Molecular Weight: 556.58
    IUPAC Name:  N-[3-fluoro-4-[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide
    SMILES:  CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F
    InChIKey: VQYYQSZNRVQLIS-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39show more
    Synonyms: Ningetinib|1394820-69-9|CT-053 free base|CT053PTSA free base|CT-053-ptsa free base|CT053PTSA|PW3Q92Z6A4|CT-053|N-(3-f...
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  7. , Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    Pamufetinib (TAS-115), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1190836-34-0        Compound CID:  44247727
    Formula:  C27H23FN4O4S        Molecular Weight: 518.56
    IUPAC Name:  4-[2-fluoro-4-[(2-phenylacetyl)carbamothioylamino]phenoxy]-7-methoxy-N-methylquinoline-6-carboxamide
    SMILES:  CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F
    InChIKey: ORRNXRYWGDUDOG-UHFFFAOYSA-N
    InChI:  InChI=1S/C27H23FN4O4S/c1-29-26(34)19-14-18-21(15-24(19)35-2)30-11-10-22(18)36-23-9-8-17(13-20(23)28)31-27(37)32-25(33)12-16-6-4-3-5-7-16/h3-11,13-15H,show more
    Synonyms: TAS115 | TAS-115 | GTPL10460 | N-Propyl acetate LBG-64752 | pamufetinib | 6-Quinolinecarboxamide, 4-(2-fluoro-4-((((2...
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    S49076
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1265965-22-7        Compound CID:  49870909
    Formula:  C22H22N4O4S        Molecular Weight: 438.5
    IUPAC Name:  3-[[(3Z)-3-[[4-(morpholin-4-ylmethyl)-1H-pyrrol-2-yl]methylidene]-2-oxo-1H-indol-5-yl]methyl]-1,3-thiazolidine-2,4-dione
    SMILES:  C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O
    InChIKey: AREYWCZYVPSHGS-NVMNQCDNSA-N
    InChI:  InChI=1S/C22H22N4O4S/c27-20-13-31-22(29)26(20)12-14-1-2-19-17(8-14)18(21(28)24-19)9-16-7-15(10-23-16)11-25-3-5-30-6-4-25/h1-2,7-10,23H,3-6,11-13H2,(H,show more
    Synonyms: s49076|1265965-22-7|S-49076|65ZUU7MATU|S-49076(Free base)|UNII-65ZUU7MATU|2,4-Thiazolidinedione, 3-((2,3-dihydro-3-((...
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    S49076
      Grade & Purity: 
    • ≥97%
    Cas Number: 1265965-22-7        Compound CID:  49870909
    Formula:  C22H22N4O4S        Molecular Weight: 438.5
    IUPAC Name:  3-[[(3Z)-3-[[4-(morpholin-4-ylmethyl)-1H-pyrrol-2-yl]methylidene]-2-oxo-1H-indol-5-yl]methyl]-1,3-thiazolidine-2,4-dione
    SMILES:  C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O
    InChIKey: AREYWCZYVPSHGS-NVMNQCDNSA-N
    InChI:  InChI=1S/C22H22N4O4S/c27-20-13-31-22(29)26(20)12-14-1-2-19-17(8-14)18(21(28)24-19)9-16-7-15(10-23-16)11-25-3-5-30-6-4-25/h1-2,7-10,23H,3-6,11-13H2,(H,show more
    Synonyms: 1265965-22-7 | s8404 | 65ZUU7MATU | HY-12965 | CID 49870909 | S-49076(Free base) | CS-6191 | 3-((3-((4-((4-Morpholiny...
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    SAR125844
      Grade & Purity: 
    • ≥96%
    Cas Number: 1116743-46-4        Compound CID:  25182860
    Formula:  C25H23FN8O2S2        Molecular Weight: 550.63
    IUPAC Name:  1-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-(2-morpholin-4-ylethyl)urea
    SMILES:  C1COCCN1CCNC(=O)NC2=NC3=C(S2)C=C(C=C3)SC4=NN=C5N4N=C(C=C5)C6=CC=C(C=C6)F
    InChIKey: ODIUNTQOXRXOIV-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-show more
    Synonyms: DTXSID901031348 | 1116743-46-4 | CALCIUM ACETATE, ANHYDROUS (EP IMPURITY) | SAR125844 | SAR-125844 | 1-(6-{[6-(4-fluo...
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    SAR125844
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1116743-46-4        Compound CID:  25182860
    Formula:  C25H23FN8O2S2        Molecular Weight: 550.63
    IUPAC Name:  1-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-(2-morpholin-4-ylethyl)urea
    SMILES:  C1COCCN1CCNC(=O)NC2=NC3=C(S2)C=C(C=C3)SC4=NN=C5N4N=C(C=C5)C6=CC=C(C=C6)F
    InChIKey: ODIUNTQOXRXOIV-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-show more
    Synonyms: SAR125844|1116743-46-4|SAR-125844|XH93U6NIJE|1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benz...
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    SCR-1481B1
      Grade & Purity: 
    • ≥98%
    Cas Number: 1174161-86-4        Compound CID:  119081412
    Formula:  C32H40ClF2N6O13P        Molecular Weight: 821.12
    IUPAC Name:  [3-[[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxopyridin-1-yl]methyl dihydrogen phosphate;2-amino-2-(hydroxyshow more
    SMILES:  C1=CC(=CC=C1C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)COP(=O)(O)O)F.C(C(CO)(CO)N)O
    InChIKey: SDCKZXWUASKHNF-UHFFFAOYSA-N
    InChI:  InChI=1S/C24H18ClF2N4O7P.C4H11NO3/c25-21-20(7-8-29-23(21)28)38-19-6-5-15(9-18(19)27)30-24(33)17-11-31(12-37-39(34,35)36)10-16(22(17)32)13-1-3-14(26)4-show more
    Synonyms: c-Met inhibitor 2
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Molecule Type
  1. Small molecule 77 items
  2. Unknown 6 items
  3. Antibody 5 items
  4. Antibody drug conjugate 1 item
Target
  1. MET 54 items
  2. AXL 14 items
  3. KDR 13 items
  4. MST1R 11 items
  5. MERTK 11 items
  6. TEK 8 items
  7. FLT3 7 items
  8. NTRK2 7 items
  9. EGFR 6 items
  10. NQO2 6 items
  11. NTRK1 6 items
  12. GPR84 5 items
  13. ERBB2 5 items
  14. DDR1 4 items
  15. TYRO3 4 items
  16. BCR 4 items
  17. FLT1 4 items
  18. ABL1 4 items
  19. ALK 4 items
  20. KIT 4 items
  21. NTRK3 4 items
  22. ERBB4 3 items
  23. EPHB6 3 items
  24. RET 3 items
  25. ROS1 3 items
  26. FLT4 3 items
  27. SLK 3 items
  28. PDGFRB 3 items
  29. TIE1 3 items
  30. JAK2 3 items
  31. CSF1R 2 items
  32. SRC 2 items
  33. HMOX2 2 items
  34. HGF 2 items
  35. FGFR1 2 items
  36. PTK2B 2 items
  37. EIF5B 2 items
  38. SMO 2 items
  39. PDGFRA 2 items
  40. LTK 2 items
  41. ABL2 2 items
  42. OPA1 2 items
  43. CYP3A4 1 item
  44. CDK7 1 item
  45. EPHA2 1 item
  46. EPHA4 1 item
  47. EPHA8 1 item
  48. EPHB1 1 item
  49. EPHB4 1 item
  50. EPHA5 1 item
  51. DDR2 1 item
  52. EPHA1 1 item
  53. EPHA3 1 item
  54. PTK6 1 item
  55. SRMS 1 item
  56. STK10 1 item
  57. FRK 1 item
  58. EPHA6 1 item
  59. EPHA7 1 item
  60. EPHB2 1 item
  61. HIPK4 1 item
  62. FGFR2 1 item
  63. FGFR3 1 item
  64. PRKACG 1 item
  65. TNK1 1 item
  66. PLK4 1 item
  67. PIP4K2C 1 item
  68. RIPK2 1 item
  69. MKNK2 1 item
  70. MAP2K2 1 item
  71. MAP3K13 1 item
  72. MAP3K19 1 item
  73. LCK 1 item
  74. MAP3K12 1 item
  75. MAP4K5 1 item
  76. LYN 1 item
  77. BLK 1 item
  78. AURKC 1 item
  79. HCK 1 item
  80. MAP2K1 1 item
  81. MAP2K5 1 item
  82. MUSK 1 item
Antibody Type
  1. Primary antibody 6 items
Application
  1. Animal Model 6 items
  2. ELISA 6 items
  3. Flow Cytometry 6 items
  4. Functional Assay 6 items
Species reactivity（Reacts with)
  1. Human 6 items
  2. Cynomolgus monkey 4 items
  3. Mouse 2 items
  4. Rat 1 item
Host species
  1. Human 6 items
Clonality
  1. Recombinant 6 items
Conjugation
  1. Unconjugated 5 items
  2. MC-VC-PAB-MMAE 1 item
Isotype
  1. Human IgG1 4 items
  2. Human IgG2SA 1 item
  3. Human IgG4SP 1 item
Physical Form
  1. Liquid 6 items
  2. Solid 4 items
Purity
  1. ≥98% 47 items
  2. ≥99% 18 items
  3. ≥97% 6 items
  4. ≥95%(SDS-PAGE&SEC-HPLC) 5 items
  5. ≥96% 2 items
  6. ≥98%(HPLC) 2 items
  7. ≥90%(SDS-PAGE&SEC-HPLC) 1 item
  8. ≥95% 1 item
  9. ≥99%(GC) 1 item
  10. ≥99.5%(GC) 1 item
Source
  1. CHO supernatant 5 items
Grade
  1. Moligand™ 52 items
  2. Animal Free 6 items
  3. Azide Free 6 items
  4. Carrier Free 6 items
  5. ExactAb™ 6 items
  6. Low Endotoxin 6 items
  7. Recombinant 6 items
  8. Validated 6 items
  9. analytical standard 1 item
  10. AR 1 item
  11. CP 1 item
  12. Standard for GC 1 item
Action Type
  1. INHIBITOR 57 items
  2. AGONIST 3 items
  3. ACTIVATOR 1 item
  4. ANTAGONIST 1 item
Price
  1. $0.00 - $500.00 109 items
  2. $500.00 - $1,000.00 7 items
  3. $1,000.00 - $1,500.00 4 items
  4. $2,000.00 - $2,500.00 1 item
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