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c-Met/HGFR

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Items 37-48 of 121

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  1. , Neurotrophic tyrosine kinase receptor inhibitor
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    Altiratinib, Neurotrophic tyrosine kinase receptor inhibitor
    Cas Number: 1345847-93-9
    Formula:  C26H21F3N4O4        Molecular Weight: 510.46
    IUPAC Name:  1-N'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES:  C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F
    InChIKey: GNNDEPIMDAZHRQ-UHFFFAOYSA-N
    InChI:  InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14show more
    Synonyms: NSC784590 | NSC-784590 | DCC-270 | J-690136 | Q27074416 | Altiratinib(DCC-2701) | s6412 | GNNDEPIMDAZHRQ-UHFFFAOYSA-N...
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    BAY-474
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1033767-86-0        Compound CID:  24959105
    Formula:  C17H15N5        Molecular Weight: 289.33
    IUPAC Name:  2,6-dimethyl-4-(3-methyl-2H-indazol-5-yl)-1,4-dihydropyridine-3,5-dicarbonitrile
    SMILES:  CC1=C2C=C(C=CC2=NN1)C3C(=C(NC(=C3C#N)C)C)C#N
    InChIKey: QKVFMAAIXZONRN-UHFFFAOYSA-N
    InChI:  InChI=1S/C17H15N5/c1-9-14(7-18)17(15(8-19)10(2)20-9)12-4-5-16-13(6-12)11(3)21-22-16/h4-6,17,20H,1-3H3,(H,21,22)
    Synonyms: 3,​5-​Pyridinedicarbonitri​le,1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​methyl-​1H-​indazol-​5-​yl)​-
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  3. , Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    Bozitinib (PLB-1001), Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1440964-89-5
    Formula:  C20H15F3N8         Molecular Weight: 424.38
    IUPAC Name:  6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
    SMILES:  CN1C=C2C=C(C(=CC2=N1)F)C(C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C6CC6)(F)F
    InChIKey: QHXLXUIZUCJRKV-UHFFFAOYSA-N
    InChI:  InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
    Synonyms: Bozitinib|Vebreltinib|1440964-89-5|PLB-1001|APL-101|Bozitinib (PLB-1001)|Vebreltinib [USAN]|CBT-101|CBI-3103|2WZP8A9V...
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  4. , Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    Bozitinib (PLB-1001), Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1440964-89-5
    Formula:  C20H15F3N8         Molecular Weight: 424.38
    IUPAC Name:  6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
    SMILES:  CN1C=C2C=C(C(=CC2=N1)F)C(C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C6CC6)(F)F
    InChIKey: QHXLXUIZUCJRKV-UHFFFAOYSA-N
    InChI:  InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
    Synonyms: 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6- fluoro-2-methyl-2H-indazol-5-yl)met...
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  5. Wish List Compare
    CEP-40783
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1437321-24-8
    Formula:  C31H26F2N4O6        Molecular Weight: 588.6
    IUPAC Name:  N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
    SMILES:  CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F
    InChIKey: FKCWHHYUMFGOPY-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-2show more
    Synonyms: CEP-40783|1437321-24-8|RXDX-106|CEP40783|N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-...
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  6. , Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of ret proto-oncogene
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    Cabozantinib (XL184, BMS-907351), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of ret proto-oncogene
    Cas Number: 849217-68-1
    Formula:  C28H24FN3O5        Molecular Weight: 501.52
    IUPAC Name:  1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES:  COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
    InChIKey: ONIQOQHATWINJY-UHFFFAOYSA-N
    InChI:  InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16show more
    Synonyms: BDBM50021574 | N-[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]-N inverted exclamation mark -(4-fluorophenyl)cyclopropan...
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  7. , Hepatocyte growth factor receptor inhibitor
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    Capmatinib (INCB28060), Hepatocyte growth factor receptor inhibitor
    Cas Number: 1029712-80-8
    Formula:  C23H17FN6O        Molecular Weight: 412.42
    IUPAC Name:  2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
    SMILES:  CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
    InChIKey: LIOLIMKSCNQPLV-UHFFFAOYSA-N
    InChI:  InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
    Synonyms: INCB-28060 | INC-280 | AMY18553 | CCG-268791 | HY-13404 | O-(4-(dimethylsulfamoyl)phenyl) O,O-dimethyl thiophosphate ...
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  8. Wish List Compare
    Crizotinib
      Grade & Purity: 
    • ≥99%
    Cas Number: 877399-52-5
    Formula:  C21H22Cl2FN5O        Molecular Weight: 450.34
    IUPAC Name:  3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
    InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N
    InChI:  InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25show more
    Synonyms: PF02341066 | PF 2341066 | 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methyl-pyrimidine-2,4-dione | NCGC0...
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    Crizotinib (PF-02341066)
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 877399-52-5
    Formula:  C21H22Cl2FN5O        Molecular Weight: 450.34
    IUPAC Name:  3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
    InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N
    InChI:  InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25show more
    Synonyms: 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methyl-pyrimidine-2,4-dione | NCGC00250400-09 | BB 0261738 | ...
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    Crizotinib hydrochloride
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1415560-69-8
    Formula:  C21H23Cl3FN5O        Molecular Weight: 486.8
    IUPAC Name:  3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;hydrochloride
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl
    InChIKey: BTDNHKQCPIBABF-UTONKHPSSA-N
    InChI:  InChI=1S/C21H22Cl2FN5O.ClH/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15;/h2-3,8-12,15,26H,4-7H2,1H3,(show more
    Synonyms: Crizotinib hydrochloride|1415560-69-8|Crizotinib (hydrochloride)|2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophen...
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    Crizotinib hydrochloride
      Grade & Purity: 
    • ≥98%
    Cas Number: 1415560-69-8
    Formula:  C21H23Cl3FN5O        Molecular Weight: 486.8
    IUPAC Name:  3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;hydrochloride
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl
    InChIKey: BTDNHKQCPIBABF-UTONKHPSSA-N
    InChI:  InChI=1S/C21H22Cl2FN5O.ClH/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15;/h2-3,8-12,15,26H,4-7H2,1H3,(show more
    Synonyms: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine hydrochloride | ...
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    DCC-2618
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 1225278-16-9
    Formula:  C26H21F2N5O3        Molecular Weight: 489.47
    IUPAC Name:  1-N'-[2,5-difluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-1-N-phenylcyclopropane-1,1-dicarboxamide
    SMILES:  CN1C=C(C=N1)C2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)F
    InChIKey: WWOXKWLDMLMYQY-UHFFFAOYSA-N
    InChI:  InChI=1S/C26H21F2N5O3/c1-33-15-16(14-30-33)21-11-18(7-10-29-21)36-23-13-19(27)22(12-20(23)28)32-25(35)26(8-9-26)24(34)31-17-5-3-2-4-6-17/h2-7,10-15H,8show more
    Synonyms: N-(2,5-Difluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-phenylcyclopropane-1,1-dicarboxamide, DCC 2...
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Molecule Type
  1. Small molecule 77 items
  2. Unknown 6 items
  3. Antibody 5 items
  4. Antibody drug conjugate 1 item
Target
  1. MET 54 items
  2. AXL 14 items
  3. KDR 13 items
  4. MST1R 11 items
  5. MERTK 11 items
  6. TEK 8 items
  7. FLT3 7 items
  8. NTRK2 7 items
  9. EGFR 6 items
  10. NQO2 6 items
  11. NTRK1 6 items
  12. GPR84 5 items
  13. ERBB2 5 items
  14. DDR1 4 items
  15. TYRO3 4 items
  16. BCR 4 items
  17. FLT1 4 items
  18. ABL1 4 items
  19. ALK 4 items
  20. KIT 4 items
  21. NTRK3 4 items
  22. ERBB4 3 items
  23. EPHB6 3 items
  24. RET 3 items
  25. ROS1 3 items
  26. FLT4 3 items
  27. SLK 3 items
  28. PDGFRB 3 items
  29. TIE1 3 items
  30. JAK2 3 items
  31. CSF1R 2 items
  32. SRC 2 items
  33. HMOX2 2 items
  34. HGF 2 items
  35. FGFR1 2 items
  36. PTK2B 2 items
  37. EIF5B 2 items
  38. SMO 2 items
  39. PDGFRA 2 items
  40. LTK 2 items
  41. ABL2 2 items
  42. OPA1 2 items
  43. CYP3A4 1 item
  44. CDK7 1 item
  45. EPHA2 1 item
  46. EPHA4 1 item
  47. EPHA8 1 item
  48. EPHB1 1 item
  49. EPHB4 1 item
  50. EPHA5 1 item
  51. DDR2 1 item
  52. EPHA1 1 item
  53. EPHA3 1 item
  54. PTK6 1 item
  55. SRMS 1 item
  56. STK10 1 item
  57. FRK 1 item
  58. EPHA6 1 item
  59. EPHA7 1 item
  60. EPHB2 1 item
  61. HIPK4 1 item
  62. FGFR2 1 item
  63. FGFR3 1 item
  64. PRKACG 1 item
  65. TNK1 1 item
  66. PLK4 1 item
  67. PIP4K2C 1 item
  68. RIPK2 1 item
  69. MKNK2 1 item
  70. MAP2K2 1 item
  71. MAP3K13 1 item
  72. MAP3K19 1 item
  73. LCK 1 item
  74. MAP3K12 1 item
  75. MAP4K5 1 item
  76. LYN 1 item
  77. BLK 1 item
  78. AURKC 1 item
  79. HCK 1 item
  80. MAP2K1 1 item
  81. MAP2K5 1 item
  82. MUSK 1 item
Antibody Type
  1. Primary antibody 6 items
Application
  1. Animal Model 6 items
  2. ELISA 6 items
  3. Flow Cytometry 6 items
  4. Functional Assay 6 items
Species reactivity（Reacts with)
  1. Human 6 items
  2. Cynomolgus monkey 4 items
  3. Mouse 2 items
  4. Rat 1 item
Host species
  1. Human 6 items
Clonality
  1. Recombinant 6 items
Conjugation
  1. Unconjugated 5 items
  2. MC-VC-PAB-MMAE 1 item
Isotype
  1. Human IgG1 4 items
  2. Human IgG2SA 1 item
  3. Human IgG4SP 1 item
Physical Form
  1. Liquid 6 items
  2. Solid 4 items
Purity
  1. ≥98% 47 items
  2. ≥99% 18 items
  3. ≥97% 6 items
  4. ≥95%(SDS-PAGE&SEC-HPLC) 5 items
  5. ≥96% 2 items
  6. ≥98%(HPLC) 2 items
  7. ≥90%(SDS-PAGE&SEC-HPLC) 1 item
  8. ≥95% 1 item
  9. ≥99%(GC) 1 item
  10. ≥99.5%(GC) 1 item
Source
  1. CHO supernatant 5 items
Grade
  1. Moligand™ 52 items
  2. Animal Free 6 items
  3. Azide Free 6 items
  4. Carrier Free 6 items
  5. ExactAb™ 6 items
  6. Low Endotoxin 6 items
  7. Recombinant 6 items
  8. Validated 6 items
  9. analytical standard 1 item
  10. AR 1 item
  11. CP 1 item
  12. Standard for GC 1 item
Action Type
  1. INHIBITOR 57 items
  2. AGONIST 3 items
  3. ACTIVATOR 1 item
  4. ANTAGONIST 1 item
Price
  1. $0.00 - $500.00 109 items
  2. $500.00 - $1,000.00 7 items
  3. $1,000.00 - $1,500.00 4 items
  4. $2,000.00 - $2,500.00 1 item
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