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c-Met/HGFR

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  1. , Hepatocyte growth factor receptor inhibitor
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    SGX-523, Hepatocyte growth factor receptor inhibitor
    Cas Number: 1022150-57-7        Compound CID:  24779724
    Formula:  C18H13N7S        Molecular Weight: 359.42
    IUPAC Name:  6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
    SMILES:  CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey: BCZUAADEACICHN-UHFFFAOYSA-N
    InChI:  InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
    Synonyms: SGX-523|1022150-57-7|SGX523|SGX 523|6-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinolin...
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    SRI 31215 TFA
      Grade & Purity: 
    • ≥98%
    Cas Number: 1832686-44-8        Compound CID:  102004307
    Formula:  C27H34F3N5O3        Molecular Weight: 533.59
    IUPAC Name:  3-[3-[(1-benzylpiperidin-4-yl)methyl]-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide;2,2,2-trifluoroacetic acid
    SMILES:  CC1CN(C(=O)N(C1)C2=CC=CC(=C2)C(=N)N)CC3CCN(CC3)CC4=CC=CC=C4.C(=O)(C(F)(F)F)O
    InChIKey: QJFJKJLPPLYFJA-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H33N5O.C2HF3O2/c1-19-15-29(25(31)30(16-19)23-9-5-8-22(14-23)24(26)27)18-21-10-12-28(13-11-21)17-20-6-3-2-4-7-20;3-2(4,5)1(6)7/h2-9,14,19,2show more
    Synonyms: SRI 31215
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  3. , Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    SU11274, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 658084-23-2        Compound CID:  9549297
    Formula:  C28H30CIN5O4S        Molecular Weight: 568.09
    IUPAC Name:  (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
    SMILES:  CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
    InChIKey: FPYJSJDOHRDAMT-KQWNVCNZSA-N
    InChI:  InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-show more
    Synonyms: BDBM50341636 | (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylide...
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  4. , Hepatocyte growth factor receptor inhibitor
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    Savolitinib (AZD6094), Hepatocyte growth factor receptor inhibitor
    Cas Number: 1313725-88-0        Compound CID:  68289010
    Formula:  C17H15N9        Molecular Weight: 345.36
    IUPAC Name:  3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine
    SMILES:  CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
    InChIKey: XYDNMOZJKOGZLS-NSHDSACASA-N
    InChI:  InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
    Synonyms: SCHEMBL12489208 | Z3041529961 | AZD6094, HMPL-504 | Q27254463 | Volitinib(Savolitinib) | 1-((S)-1-(IMIDAZO(1,2-A)PYRI...
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  5. , Vascular endothelial growth factor receptor inhibitor
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    Semaxanib (SU5416), Vascular endothelial growth factor receptor inhibitor
    Cas Number: 194413-58-6        Compound CID:  5329098
    Formula:  C15H14N2O        Molecular Weight: 238.28
    IUPAC Name:  (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
    SMILES:  CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
    InChIKey: WUWDLXZGHZSWQZ-WQLSENKSSA-N
    InChI:  InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
    Synonyms: (Z)-Semaxinib | BRN 0844684 | CAS-204005-46-9 | NCGC00094381-01 | SCHEMBL194769 | SCHEMBL19571 | SU005416 | Lopac0_00...
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  6. , Hepatocyte growth factor receptor inhibitor
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    Tivantinib (ARQ 197), Hepatocyte growth factor receptor inhibitor
    Cas Number: 905854-02-6        Compound CID:  11494412
    Formula:  C23H19N3O2        Molecular Weight: 369.42
    IUPAC Name:  (3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
    SMILES:  C1CC2=C3C(=CC=C2)C(=CN3C1)C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
    InChIKey: UCEQXRCJXIVODC-PMACEKPBSA-N
    InChI:  InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,show more
    Synonyms: (+/-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione | (+/-)-trans-3-...
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  7. , Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    X-376, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1365267-27-1        Compound CID:  56960447
    Formula:  C25H25Cl2FN6O3        Molecular Weight: 547.41
    IUPAC Name:  6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
    InChIKey: ONPGOSVDVDPBCY-CQSZACIVSA-N
    InChI:  InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14Hshow more
    Synonyms: 7DR7JMB8BH | NSC800968 | NSC-800968 | s6505 | X-396 | MS-30029 | X-376; X-396 | DB13104 | CS-6077 | AKOS030528612 | B...
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  8. , Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    X-376, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 1365267-27-1        Compound CID:  56960447
    Formula:  C25H25Cl2FN6O3        Molecular Weight: 547.41
    IUPAC Name:  6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
    SMILES:  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
    InChIKey: ONPGOSVDVDPBCY-CQSZACIVSA-N
    InChI:  InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14Hshow more
    Synonyms: 1365267-27-1|X-376|X-396|UNII-7DR7JMB8BH|(R)-6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazi...
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  9. Wish List Compare
    c-Met/RON Dual Kinase Inhibitor inhibitor
      Grade & Purity: 
    • 10mM in DMSO
    Cas Number: 913376-84-8
    Formula:  C31H29FN4O5        Molecular Weight: 556.59
    IUPAC Name:  N-[3-fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
    SMILES:  CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F
    InChIKey: UYMSIPINLJNNOU-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26show more
    Synonyms: AMG-1|913376-84-8|RON-IN-1|N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3...
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  10. Wish List Compare
    5-Chloro-3-(thiophen-2-ylmethylene)indolin-2-one
      Grade & Purity: 
    • ≥98%
    Cas Number: 186611-58-5
    Formula:  C13H8ClNOS        Molecular Weight: 261.73
    IUPAC Name:  (3Z)-5-chloro-3-(thiophen-2-ylmethylidene)-1H-indol-2-one
    SMILES:  C1=CSC(=C1)C=C2C3=C(C=CC(=C3)Cl)NC2=O
    InChIKey: ZYHHCVFJHNWKDY-XFFZJAGNSA-N
    InChI:  InChI=1S/C13H8ClNOS/c14-8-3-4-12-10(6-8)11(13(16)15-12)7-9-2-1-5-17-9/h1-7H,(H,15,16)/b11-7-
    Synonyms: 5-Chloro-3-(thiophen-2-ylmethylene)indolin-2-one
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    N'-(5-fluoro-2-oxoindolin-3-ylidene)-4-hydroxybenzohydrazide
      Grade & Purity: 
    • ≥98%
    Cas Number: 330572-32-2        Compound CID:  837637
    Formula:  C15H10FN3O3        Molecular Weight: 299.2566032
    IUPAC Name:  N-[(5-fluoro-2-hydroxy-1H-indol-3-yl)imino]-4-hydroxybenzamide
    SMILES:  C1=CC(=CC=C1C(=O)N=NC2=C(NC3=C2C=C(C=C3)F)O)O
    InChIKey: NBNLEALJOLHMEO-UHFFFAOYSA-N
    InChI:  InChI=1S/C15H10FN3O3/c16-9-3-6-12-11(7-9)13(15(22)17-12)18-19-14(21)8-1-4-10(20)5-2-8/h1-7,17,20,22H
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  12. , INHIBITOR of Hepatocyte growth factor inhibitor
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    Ficlatuzumab (anti-HGF), INHIBITOR of Hepatocyte growth factor inhibitor
      Application: 
    • Animal Model
    • ELISA
    • Flow Cytometry
    • Functional Assay
    Associated targets:  HGF
      Short Overview: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated    
      Species reactivity（Reacts with): Cynomolgus monkey, Human    Isotype: Human IgG1    
      Host species: Human    Conjugation: Unconjugated    
    Cas Number: 1174900-84-5
    Synonyms: Hepatopoietin-A | Scatter factor | SF
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Molecule Type
  1. Small molecule 77 items
  2. Unknown 6 items
  3. Antibody 5 items
  4. Antibody drug conjugate 1 item
Target
  1. MET 54 items
  2. AXL 14 items
  3. KDR 13 items
  4. MST1R 11 items
  5. MERTK 11 items
  6. TEK 8 items
  7. FLT3 7 items
  8. NTRK2 7 items
  9. EGFR 6 items
  10. NQO2 6 items
  11. NTRK1 6 items
  12. GPR84 5 items
  13. ERBB2 5 items
  14. DDR1 4 items
  15. TYRO3 4 items
  16. BCR 4 items
  17. FLT1 4 items
  18. ABL1 4 items
  19. ALK 4 items
  20. KIT 4 items
  21. NTRK3 4 items
  22. ERBB4 3 items
  23. EPHB6 3 items
  24. RET 3 items
  25. ROS1 3 items
  26. FLT4 3 items
  27. SLK 3 items
  28. PDGFRB 3 items
  29. TIE1 3 items
  30. JAK2 3 items
  31. CSF1R 2 items
  32. SRC 2 items
  33. HMOX2 2 items
  34. HGF 2 items
  35. FGFR1 2 items
  36. PTK2B 2 items
  37. EIF5B 2 items
  38. SMO 2 items
  39. PDGFRA 2 items
  40. LTK 2 items
  41. ABL2 2 items
  42. OPA1 2 items
  43. CYP3A4 1 item
  44. CDK7 1 item
  45. EPHA2 1 item
  46. EPHA4 1 item
  47. EPHA8 1 item
  48. EPHB1 1 item
  49. EPHB4 1 item
  50. EPHA5 1 item
  51. DDR2 1 item
  52. EPHA1 1 item
  53. EPHA3 1 item
  54. PTK6 1 item
  55. SRMS 1 item
  56. STK10 1 item
  57. FRK 1 item
  58. EPHA6 1 item
  59. EPHA7 1 item
  60. EPHB2 1 item
  61. HIPK4 1 item
  62. FGFR2 1 item
  63. FGFR3 1 item
  64. PRKACG 1 item
  65. TNK1 1 item
  66. PLK4 1 item
  67. PIP4K2C 1 item
  68. RIPK2 1 item
  69. MKNK2 1 item
  70. MAP2K2 1 item
  71. MAP3K13 1 item
  72. MAP3K19 1 item
  73. LCK 1 item
  74. MAP3K12 1 item
  75. MAP4K5 1 item
  76. LYN 1 item
  77. BLK 1 item
  78. AURKC 1 item
  79. HCK 1 item
  80. MAP2K1 1 item
  81. MAP2K5 1 item
  82. MUSK 1 item
Antibody Type
  1. Primary antibody 6 items
Application
  1. Animal Model 6 items
  2. ELISA 6 items
  3. Flow Cytometry 6 items
  4. Functional Assay 6 items
Species reactivity（Reacts with)
  1. Human 6 items
  2. Cynomolgus monkey 4 items
  3. Mouse 2 items
  4. Rat 1 item
Host species
  1. Human 6 items
Clonality
  1. Recombinant 6 items
Conjugation
  1. Unconjugated 5 items
  2. MC-VC-PAB-MMAE 1 item
Isotype
  1. Human IgG1 4 items
  2. Human IgG2SA 1 item
  3. Human IgG4SP 1 item
Physical Form
  1. Liquid 6 items
  2. Solid 4 items
Purity
  1. ≥98% 47 items
  2. ≥99% 18 items
  3. ≥97% 6 items
  4. ≥95%(SDS-PAGE&SEC-HPLC) 5 items
  5. ≥96% 2 items
  6. ≥98%(HPLC) 2 items
  7. ≥90%(SDS-PAGE&SEC-HPLC) 1 item
  8. ≥95% 1 item
  9. ≥99%(GC) 1 item
  10. ≥99.5%(GC) 1 item
Source
  1. CHO supernatant 5 items
Grade
  1. Moligand™ 52 items
  2. Animal Free 6 items
  3. Azide Free 6 items
  4. Carrier Free 6 items
  5. ExactAb™ 6 items
  6. Low Endotoxin 6 items
  7. Recombinant 6 items
  8. Validated 6 items
  9. analytical standard 1 item
  10. AR 1 item
  11. CP 1 item
  12. Standard for GC 1 item
Action Type
  1. INHIBITOR 57 items
  2. AGONIST 3 items
  3. ACTIVATOR 1 item
  4. ANTAGONIST 1 item
Price
  1. $0.00 - $500.00 109 items
  2. $500.00 - $1,000.00 7 items
  3. $1,000.00 - $1,500.00 4 items
  4. $2,000.00 - $2,500.00 1 item
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