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Golimumab (anti-TNFa) - Primary antibody, specific to TNF, >95%, high purity, Human IgG1, INHIBITOR of TNF-alpha inhibitor, INHIBITOR of TNF-alpha inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175552
Grouped product items
SKU Size
Availability
 Price Qty
Ab175552-100μg
100μg
10
$69.90
Ab175552-1mg
1mg
4
$319.90
Ab175552-5mg
5mg
1
$729.90
Ab175552-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,169.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: TNF
Accession#:P01375 (15) Apoptosis (4276) Extrinsic Pathway (436) Gene ID:7124 (15) Intrinsic Pathway (690) TNF (18) TNF-alpha (9)

Basic Description

Product Name Golimumab (anti-TNFa) - Primary antibody, specific to TNF, >95%, high purity, Human IgG1, INHIBITOR of TNF-alpha inhibitor
Synonyms APC1 antibody | APC1 protein antibody | Cachectin antibody | DIF antibody | Differentiation inducing factor antibody | Macrophage cytotoxic factor antibody | Tnf antibody | TNF superfamily member 2 antibody | TNF superfamily, member 2 antibody | TNF, macr
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TNF
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of TNF-alpha inhibitor
Product Description

Golimumab (anti-TNFa) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab (anti-TNFa) has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab (anti-TNFa) acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab (anti-TNFa) has the anticancer activity and induces cell apoptosis. Golimumab (anti-TNFa) can be used for rheumatoid arthritis, Crohn's disease and cancer research.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 197.7 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 476181-74-5

Associated Targets(Human)

TNF Tclin Tumor necrosis factor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Golimumab (anti-TNFa) (Ab175552) - ELISA
Immobilized Recombinant Human TNF-α Protein (rp156007) at 2.0 μg/mL can bind Golimumab (anti-TNFa) (Ab175552) with the EC₅₀ of 27.30 ng/mL.

Golimumab (anti-TNFa) (Ab175552) - SEC
The purity of Golimumab (anti-TNFa) (Ab175552) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303918 Certificate of Analysis Mar 29, 2024 Ab175552
ZJ24F0303917 Certificate of Analysis Mar 29, 2024 Ab175552
ZJ24F0303916 Certificate of Analysis Mar 29, 2024 Ab175552

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