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Feladilimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, high purity, Human IgG4PE, AGONIST of Inducible T-cell costimulator agonist, AGONIST of Inducible T-cell costimulator agonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4PE
  • Conjugation: Unconjugated
In stock
Item Number
Ab176561
Grouped product items
SKU Size
Availability
Price Qty
Ab176561-100μg
100μg
10
$59.90
Ab176561-1mg
1mg
4
$289.90
Ab176561-5mg
5mg
1
$749.90
Ab176561-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4PE; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Feladilimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, high purity, Human IgG4PE, AGONIST of Inducible T-cell costimulator agonist
Synonyms Activation-inducible lymphocyte immunomediatory molecule
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ICOS
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type AGONIST
Mechanism of action AGONIST of Inducible T-cell costimulator agonist
Product Description

Feladilimab (anti-ICOS) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab (anti-ICOS) binds to ICOS-expressing T cells. Feladilimab (anti-ICOS) has the potential for the research of cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4PE
Light Chain Type kappa
SDS-PAGE 27.0 kDa (Light Chain) & 53.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2252518-85-5

Associated Targets(Human)

ICOS Tbio Inducible T-cell costimulator (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Feladilimab (anti-ICOS) (Ab176561) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling ICOS (red) with Feladilimab (anti-ICOS) (Ab176561). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Feladilimab (anti-ICOS) (Ab176561) - SEC
The purity of Feladilimab (anti-ICOS) (Ab176561) is more than 95% verified by HPLC.

Feladilimab (anti-ICOS) (Ab176561) - ELISA
Immobilized hu-ICOS ECD-21-140-Fc at 2.0 μg/mL can bind Feladilimab (anti-ICOS) (Ab176561) with the EC₅₀ of 33.30 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404319 Certificate of Analysis Apr 10, 2024 Ab176561
ZJ24F0404318 Certificate of Analysis Apr 10, 2024 Ab176561
ZJ24F0404317 Certificate of Analysis Apr 09, 2024 Ab176561

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