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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176561-100μg
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100μg |
10
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$59.90
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Ab176561-1mg
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1mg |
4
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$289.90
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Ab176561-5mg
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5mg |
1
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$749.90
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Ab176561-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,189.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4PE; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Feladilimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, high purity, Human IgG4PE, AGONIST of Inducible T-cell costimulator agonist |
|---|---|
| Synonyms | Activation-inducible lymphocyte immunomediatory molecule |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ICOS |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | AGONIST |
| Mechanism of action | AGONIST of Inducible T-cell costimulator agonist |
| Product Description |
Feladilimab (anti-ICOS) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab (anti-ICOS) binds to ICOS-expressing T cells. Feladilimab (anti-ICOS) has the potential for the research of cancer. |
| Isotype | Human IgG4PE |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 53.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2252518-85-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Feladilimab (anti-ICOS) (Ab176561) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling ICOS (red) with Feladilimab (anti-ICOS) (Ab176561). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Feladilimab (anti-ICOS) (Ab176561) - SEC
The purity of Feladilimab (anti-ICOS) (Ab176561) is more than 95% verified by HPLC.
Feladilimab (anti-ICOS) (Ab176561) - ELISA
Immobilized hu-ICOS ECD-21-140-Fc at 2.0 μg/mL can bind Feladilimab (anti-ICOS) (Ab176561) with the EC₅₀ of 33.30 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 10, 2024 | Ab176561 | |
| Certificate of Analysis | Apr 10, 2024 | Ab176561 | |
| Certificate of Analysis | Apr 09, 2024 | Ab176561 |
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