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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab183458-100μg
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100μg |
10
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$109.90
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Ab183458-1mg
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1mg |
4
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$519.90
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Ab183458-5mg
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5mg |
1
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$1,299.90
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Ab183458-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$2,079.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | MEDI-570 (anti-ICOS) - Primary antibody, specific to ICOS, Human IgG1, INHIBITOR of Inducible T-cell costimulator inhibitor |
|---|---|
| Synonyms | Activation inducible lymphocyte immunomediatory molecule antibody | Activation-inducible lymphocyte immunomediatory molecule antibody | AILIM antibody | CD278 antibody | CD278 antigen antibody | CD28-related Protein-1 antibody | CRP1 antibody | CVID1 anti |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ICOS |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Inducible T-cell costimulator inhibitor |
| Product Description |
MEDI-570 (anti-ICOS) is a Fc-optimized humanized immunoglobulin (Ig) G1 monoclonal antibody (MoAb) directed against the inducible T-cell co-stimulator (ICOS, CD278) with potential immune checkpoint inhibitory and antineoplastic activities. It has the potential to treat non-Hodgkin lymphomas. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 212.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2179209-59-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
MEDI-570 (anti-ICOS) (Ab183458) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling ICOS (red) with MEDI-570 (anti-ICOS) (Ab183458) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
MEDI-570 (anti-ICOS) (Ab183458) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) MOLT-4 cells labelling ICOS (red) with MEDI-570 (anti-ICOS) (Ab183458) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
MEDI-570 (anti-ICOS) (Ab183458) - ELISA
Immobilized Cynomolgus/Rhesus Macaque ICOS/CD278, His Tag at 2.0 μg/mL can bind MEDI-570 (anti-ICOS) (Ab183458) with the EC50 of 19.55 ng/mL.
MEDI-570 (anti-ICOS) (Ab183458) - SEC
The purity of MEDI-570 (anti-ICOS) (Ab183458) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 26, 2024 | Ab183458 | |
| Certificate of Analysis | Apr 26, 2024 | Ab183458 | |
| Certificate of Analysis | Apr 26, 2024 | Ab183458 |
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