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MEDI-570 (anti-ICOS) - Primary antibody, specific to ICOS, Human IgG1, INHIBITOR of Inducible T-cell costimulator inhibitor, INHIBITOR of Inducible T-cell costimulator inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab183458
Grouped product items
SKU Size
Availability
Price Qty
Ab183458-100μg
100μg
10
$109.90
Ab183458-1mg
1mg
4
$519.90
Ab183458-5mg
5mg
1
$1,299.90
Ab183458-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name MEDI-570 (anti-ICOS) - Primary antibody, specific to ICOS, Human IgG1, INHIBITOR of Inducible T-cell costimulator inhibitor
Synonyms Activation inducible lymphocyte immunomediatory molecule antibody | Activation-inducible lymphocyte immunomediatory molecule antibody | AILIM antibody | CD278 antibody | CD278 antigen antibody | CD28-related Protein-1 antibody | CRP1 antibody | CVID1 anti
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ICOS
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Inducible T-cell costimulator inhibitor
Product Description

MEDI-570 (anti-ICOS) is a Fc-optimized humanized immunoglobulin (Ig) G1 monoclonal antibody (MoAb) directed against the inducible T-cell co-stimulator (ICOS, CD278) with potential immune checkpoint inhibitory and antineoplastic activities. It has the potential to treat non-Hodgkin lymphomas.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 212.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2179209-59-5

Associated Targets(Human)

ICOS Tbio Inducible T-cell costimulator (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

MEDI-570 (anti-ICOS) (Ab183458) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling ICOS (red) with MEDI-570 (anti-ICOS) (Ab183458) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

MEDI-570 (anti-ICOS) (Ab183458) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) MOLT-4 cells labelling ICOS (red) with MEDI-570 (anti-ICOS) (Ab183458) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.


MEDI-570 (anti-ICOS) (Ab183458) - ELISA
Immobilized Cynomolgus/Rhesus Macaque ICOS/CD278, His Tag at 2.0 μg/mL can bind MEDI-570 (anti-ICOS) (Ab183458) with the EC50 of 19.55 ng/mL.

MEDI-570 (anti-ICOS) (Ab183458) - SEC
The purity of MEDI-570 (anti-ICOS) (Ab183458) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404939 Certificate of Analysis Apr 26, 2024 Ab183458
ZJ24F0404938 Certificate of Analysis Apr 26, 2024 Ab183458
ZJ24F0404937 Certificate of Analysis Apr 26, 2024 Ab183458

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