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Vopratelimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, high purity, Human IgG1, AGONIST of Inducible T-cell costimulator agonist, AGONIST of Inducible T-cell costimulator agonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176563
Grouped product items
SKU Size
Availability
Price Qty
Ab176563-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab176563-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$529.90
Ab176563-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,379.90
Ab176563-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,339.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Vopratelimab (anti-ICOS) - Primary antibody, specific to ICOS, >95%, high purity, Human IgG1, AGONIST of Inducible T-cell costimulator agonist
Synonyms Activation-inducible lymphocyte immunomediatory molecule
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ICOS
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type AGONIST
Mechanism of action AGONIST of Inducible T-cell costimulator agonist
Product Description

Vopratelimab (anti-ICOS) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab (anti-ICOS) retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab (anti-ICOS) has antitumor immune response.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.8 kDa
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2039148-04-2

Associated Targets(Human)

ICOS Tbio Inducible T-cell costimulator (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Vopratelimab (anti-ICOS) (Ab176563) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling ICOS with Vopratelimab (anti-ICOS) (Ab176563) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Vopratelimab (anti-ICOS) (Ab176563) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling ICOS (red) with Vopratelimab (anti-ICOS) (Ab176563) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Vopratelimab (anti-ICOS) (Ab176563) - SEC
The purity of Vopratelimab (anti-ICOS) (Ab176563) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001521 Certificate of Analysis Nov 02, 2023 Ab176563
ZJ23F1001520 Certificate of Analysis Nov 02, 2023 Ab176563

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