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孕烯醇酮

内源性类固醇激素和神经类固醇。PXR激动剂。
5篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
P129412-5g
 5g 现货 Stock Image
P129412-25g
 25g 现货 Stock Image
P129412-100g
 100g 现货 Stock Image
P129412-500g
 500g 现货 Stock Image
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基本描述

别名 孕甾烯醇酮
英文别名 3b-Hydroxypregn-5-en-20-one | PREGNENOLONE [WHO-DD] | PREGNENOLONE [INN] | 73R90F7MQ8 | NSC 1616 | Skinostelon | Spectrum5_002057 | 5-Pregnen-3beta-ol-20-one, >=98% | DB02789 | Tox21_112011 | GTPL2376 | HMS3884G16 | Pregnolone | 3beta-Hydroxy-5-pregnene-2
规格或纯度 Moligand™, ≥98%
英文名称 Pregnenolone
生化机理 神经类固醇 "是在大脑而非外周合成的类固醇，是少数 "神经类固醇 "之一。这些神经类固醇水平的降低与啮齿类动物随着年龄增长而出现的认知能力下降有关，但对人类的研究却相互矛盾。PXR 激动剂。具有抗焦虑作用，可防止饮食引起的体内胰岛素抵抗。
储存温度 2-8°C储存
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.

Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.
An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.
纯度 ≥98%

关联靶点（人）

SHBG Tchem 性激素结合球蛋白(Sex hormone-binding globulin) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SULT2A1 Tbio Alcohol sulfotransferase (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SERPINA6 Tchem Corticosteroid binding globulin (274 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A-375 (9258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Daoy (570 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-468 (9477 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
WiDr (1835 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KB (17409 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 (197 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Skin (286 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSD17B7 Tchem 3-keto-steroid reductase (330 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SULT2B1 Tbio Sulfotransferase family cytosolic 2B member 1 (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A8 Tbio UDP-glucuronosyltransferase 1-8 (233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A10 Tbio UDP-glucuronosyltransferase 1-10 (257 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ERG11 Cytochrome P450 51 (617 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1i3 Constitutive androstane receptor (427 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Shbg Testis-specific androgen-binding protein (10 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SULT1E1 Estrogen sulfotransferase (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P388 (20296 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-12 (7051 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504751770
分子类型 小分子
IIUPAC Name 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
INCHI 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChi Key ORNBQBCIOKFOEO-QGVNFLHTSA-N
Smiles CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Isomeric SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
分子量 316.48
Reaxy-Rn 1915502
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1915502&ln=

化学和物理性质

溶解性 Soluble in ethanol (22 mg/ml at 25 °C), chloroform, and DMSO (22 mg/ml at 25 °C). Insoluble in water, , , DMSO 22 mg/mL Water Ethanol 22 mg/mL
分子量 316.500 g/mol
XLogP3 4.200
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 316.24 Da
单同位素质量Monoisotopic Mass 316.24 Da
拓扑极表面积Topological Polar Surface Area 37.300 Ų
重原子数Heavy Atom Count 23
形式电荷Formal Charge 0
复杂度Complexity 550.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 7
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07,   GHS08
信号词 警告

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 货号
A2411014 分析证书 P129412
A2513519 分析证书 P129412
L2109333 分析证书 P129412
H2201089 分析证书 P129412
D2515018 分析证书 P129412
I2208063 分析证书 P129412
F2307376 分析证书 P129412
J2324044 分析证书 P129412
D2515017 分析证书 P129412
I2208064 分析证书 P129412
I2208065 分析证书 P129412
I2208066 分析证书 P129412

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引用文献

1. Vallée M, Mayo W, Le Moal M.  (2001)  Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging..  Brain Res Brain Res Rev,  37  (1-3): (301-12).  [PMID:11744095]
2. Reddy DS.  (2010)  Neurosteroids: endogenous role in the human brain and therapeutic potentials..  Prog Brain Res,  186  (113-37).  [PMID:21094889]
3. Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD.  (2011)  Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence..  Neuroscience,  191  (78-90).  [PMID:21756978]
4. Harteneck C.  (2013)  Pregnenolone sulfate: from steroid metabolite to TRP channel ligand..  Molecules,  18  (10): (12012-28).  [PMID:24084011]
5. Ruosi Zhang, Mingdong Yao, Haidi Ma, Wenhai Xiao, Ying Wang, Yingjin Yuan.  (2023)  Modular Coculture to Reduce Substrate Competition and Off-Target Intermediates in Androstenedione Biosynthesis.  ACS Synthetic Biology,  12  (3): (788–799).  [PMID:36857753] [10.1021/acssynbio.2c00590]
6. Xiao-San Li, Mao-Xun Yang, Yu-Hao Luo, He-Hui Zhan, Mei-Fang Chen, Yong-Mei Huang, Li Liu, Xue-Mei Yang.  (2022)  Design, Synthesis and Anticancer Activity of Novel Steroidal Derivatives with D-Ring Fused or Substituted N-Heterocyclic Systems.  CHEMISTRY & BIODIVERSITY,  19  (10): (e202200648).  [PMID:36043381] [10.1002/cbdv.202200648]
7. Yaqin Jia, Zhe Wang, Yuyi Feng, Meixian Wang, Lili Jiang, Zhijun Yu, Xiaoguang Shao, Guiyuan He, Yong Liu.  (2022)  Validity of the association between five steroid hormones quantification and female infertility conditions: A new perspective for clinical diagnosis.  STEROIDS,  186  (109086).  [PMID:35803387] [10.1016/j.steroids.2022.109086]
8. Di Xu, Mengyun Wu, Xue Li, Mingyu Xia, Dongchun Liu, Yinghui Dai, Qing Yu, Bin Wu, Dong Wang.  (2018)  Cloning, prokaryotic expression and function of the Bufo bufo gargarizans 3β-hydroxysteroid dehydrogenase (3βHSD) gene.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  120  (673).  [PMID:30170058] [10.1016/j.ijbiomac.2018.08.165]
9. Jixiu Deng, Pengshuai Zhang, Han Sun, Wang Rongrong, Binbin Wu, Yuemei Li, Beibei Feng, Haowei Sun, Shuoye Yang.  (2025)  Insight into the solid-liquid equilibrium behavior and apparent thermodynamic analysis of polymorphic pregnenolone (Form Ⅰ) in thirteen neat solvents.  THERMOCHIMICA ACTA,  (179979).  [10.1016/j.tca.2025.179979]

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