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卡那霉素 硫酸酯 来源于卡那霉素链霉菌

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货号 (SKU) 包装规格 是否现货 价格 数量
K432461-1g
1g 现货 Stock Image
K432461-5g
5g 现货 Stock Image
K432461-25g
25g 现货 Stock Image

基本描述

别名 卡那霉素 A, 卡那霉素碱 硫酸盐
英文别名 Cantrex | KANAMYCIN MONO SULFATE | Kannasyn | J80EX28SMQ | KANAMYCIN SULFATE [GREEN BOOK] | KANAMYCIN A SULFATE [MI] | Kanamytrex | Kanatrol | s2315 | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydro
规格或纯度 BioReagent, 用于植物细胞培养, powder
英文名称 Kanamycin sulfate from Streptomyces kanamyceticus
生化机理 作用机制:该产品通过与70S核糖体亚基结合,抑制易位并引起错误编码而起作用。 耐药机制:氨基糖苷类修饰酶(包括乙酰转移酶、磷酸转移酶、核苷酸转移酶)可以改变这种抗生素,阻止其与核糖体相互作用。 抗菌谱:硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
备注 注意: Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
产品介绍

在生物技术中用于抑制蛋白质合成。建议以 100mg/L 的量用于细胞培养应用。 Chemical structure: aminoglycoside


制备说明

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus . It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100μg/mL. Chemical structure: aminoglycoside


Application

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

关联靶点(人)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Proteus vulgaris (5823 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Micrococcus luteus (7463 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Proteus mirabilis (3894 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella (646 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella enteritidis (727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Serratia marcescens (3237 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pyogenes (16140 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus cereus (7522 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504758763
分子类型 小分子
IIUPAC Name (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
INCHI 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChi Key OOYGSFOGFJDDHP-KMCOLRRFSA-N
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
关联CAS 70560-51-9
UN Number 2811
Packing Group III
分子量 582.58
Beilstein号 18(4)7631
Reaxy-Rn 18153648
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18153648&ln=

化学和物理性质

溶解性 H2O:10-50mg/mL(作为储备溶液。储备溶液应在 2-8°C 下储存。在 37°C 下可稳定保存 5 天。)
比旋光度 117.5 ° (C=1, H2O)
熔点 250°C(dec.)(lit.)
分子量 582.600 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 13
氢键受体数Hydrogen Bond Acceptor Count 19
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 582.205 Da
单同位素质量Monoisotopic Mass 582.205 Da
拓扑极表面积Topological Polar Surface Area 366.000 Ų
重原子数Heavy Atom Count 38
形式电荷Formal Charge 0
复杂度Complexity 720.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 15
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性(GHS)

象形图 GHS08
信号词 危险
危险声明

H317: 可能引起皮肤过敏反应

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

H360FD: 可能损害生育能力; 可能会伤害未出生的孩子

预防措施声明

P201: 使用前获取特殊说明

P202: 在阅读并理解所有安全预防措施之前,不要进行操作。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P272: 被污染的工作服不允许离开工作场所

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P281: 根据需要使用个人防护设备。

P285: 如果通风不良,请佩戴呼吸防护装置。

P363: 再次使用之前,请清洗受污染的衣物。

P302+P352: 如皮肤沾染:用水充分清洗。

P304+P341: 如果吸入:如果呼吸困难,请将患者转移到新鲜空气处并保持呼吸舒适的休息姿势。

P308+P311: 如接触到或有疑虑:呼叫急救中心/医生。

P342+P311: 如有呼吸系统病症:呼叫急救中心/医生。

P403: 存放在通风良好的地方。

RTECS NZ3225030
Class 6.1
Merck Index 5281
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
G2301535 分析证书 K432461
G2301536 分析证书 K432461
G2301539 分析证书 K432461
G2301542 分析证书 K432461
G2301543 分析证书 K432461
G2301544 分析证书 K432461

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引用文献

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