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来自卡那霉素链霉菌的卡那霉素二硫酸盐

1篇引用文献 COA COA
    级别和纯度:
  • 氨基糖苷类抗生素
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
K475878-1g
 1g 期货 Stock Image
K475878-5g
 5g 期货 Stock Image
K475878-25g
 25g 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
main product photo

基本描述

英文别名 D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-2-DEOXY-, SULFATE (1:2) (SALT) | DTXSID00641058 | Kanamycin A disulfate | Kanamycin A acid sulfate | Kanamycin acid sulfate [WHO-IP] | Kan
规格或纯度 氨基糖苷类抗生素
英文名称 Kanamycin disulfate salt from Streptomyces kanamyceticus
产品介绍

Description

Chemical structure: aminoglycosideKanamycin sulfate is a broad spectrum minoglycoside-antibiotic It is used as an additive in culture media for the isolation of group DStreptococcion Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells. It is used to inhibit shoot regeneration from Siberian Elmleaf explants. It is recommended for use in cell culture applications at 100 mg/mL.

Preparation instructions

Kanamycin sulfate is soluble in water at 10 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.

名称和识别符

IIUPAC Name (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
INCHI 1S/C18H36N4O11.2H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;2*1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;2*(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;;/m1../s1
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O.OS(=O)(=O)O
PubChem CID 24721551

化学和物理性质

溶解性  水：10 毫克/毫升
分子量 680.700 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 15
氢键受体数Hydrogen Bond Acceptor Count 23
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 680.173 Da
单同位素质量Monoisotopic Mass 680.173 Da
拓扑极表面积Topological Polar Surface Area 449.000 Ų
重原子数Heavy Atom Count 43
形式电荷Formal Charge 0
复杂度Complexity 720.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 15
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 3

安全和危险性（GHS）

象形图 GHS08
信号词 危险
危险声明

H360: 可能损害生育力或未出生的孩子
预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。
WGK Germany 3
个人防护装备 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

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引用文献

1. Dale W Hailey,Brock Roberts,Kelly N Owens,Andrew K Stewart,Tor Linbo,Remy Pujol,Seth L Alper,Edwin W Rubel,David W Raible.  (2012-10-17)  Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone..  PLoS genetics,  8  ((10)): (e1002971-e1002971).  [PMID:23071446]
2. Adam C Palmer,Erdal Toprak,Michael Baym,Seungsoo Kim,Adrian Veres,Shimon Bershtein,Roy Kishony.  (2015-06-11)  Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes..  Nature communications,  6  (7385-7385).  [PMID:26060115]
3. Cicera R Lazzarotto,Nhu T Nguyen,Xing Tang,Jose Malagon-Lopez,Jimmy A Guo,Martin J Aryee,J Keith Joung,Shengdar Q Tsai.  (2018-10-21)  Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq..  Nature protocols,  13  ((11)): (2615-2642).  [PMID:30341435]
4. Joshua N Gustine,Matthew B Au,John R Haserick,Erik C Hett,Eric J Rubin,Frank C Gibson,Lingyi L Deng.  (2019-01-04)  Cell Wall Hydrolytic Enzymes Enhance Antimicrobial Drug Activity Against Mycobacterium..  Current microbiology,  76  ((4)): (398-409).  [PMID:30603964]
5. Lokender Kumar,John Brice,Linda Toberer,Judith Klein-Seetharaman,Daniel Knauss,Susanta K Sarkar.  (2019-03-27)  Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides..  PloS one,  14  ((3)): (e0214411-e0214411).  [PMID:30913239]
6. Dorin Harpaz,Boris Veltman,Yael Sadeh,Robert S Marks,Nirit Bernstein,Evgeni Eltzov.  (2020-12-11)  The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E.\xa0coli..  Chemosphere,  263  (128241-128241).  [PMID:33297188]
7. Michael G Leitner,Christian R Halaszovich,Dominik Oliver.  (2010-10-12)  Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate..  Molecular pharmacology,  79  ((1)): (51-60).  [PMID:20935082]
8. Victoria Hsiao,Yutaka Hori,Paul Wk Rothemund,Richard M Murray.  (2016-05-20)  A population-based temporal logic gate for timing and recording chemical events..  Molecular systems biology,  12  ((5)): (869-869).  [PMID:27193783]
9. Yizhen Zhang, Yu-Cai He, Cuiluan Ma.  (2024)  Efficient synthesis of vanillylamine through bioamination of lignin-derived vanillin by recombinant E. coli containing ω-transaminase from Caulobacter sp. D5 in dimethyl sulfoxide-water.  BIORESOURCE TECHNOLOGY,  413  (131526).  [PMID:39321936] [10.1016/j.biortech.2024.131526]

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