| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I109591-10mg |
10mg |
现货  |
| |
| I109591-20mg |
20mg |
现货 |
|
| 别名 | 3'-甲基槲皮素, 3'-甲氧基-3,4',5,7-四羟基黄酮, 3,4',5,7-四羟基3'-甲氧基黄酮, 异戊烯醇, 槲皮素3'-甲醚 |
|---|---|
| 英文别名 | NCGC00163572-02 | 3'-Methoxyquercetin | 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one | SR-05000002256-2 | 3,4',5,7-Tetrahydroxy-3'-methoxyflavone | 3,4',5,7-tetrahydroxy-3'-methoxy-flavone | EX-A6804 | Isorhamnetol | UNII-07X3IB4R4 |
| 规格或纯度 | 分析标准品, Moligand™, ≥98%(HPLC) |
| 英文名称 | Isorhamnetin |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells. |
| 纯度 | ≥98%(HPLC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 207-545-5 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one |
| INCHI | 1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3 |
| InChi Key | IZQSVPBOUDKVDZ-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O |
| Isomeric SMILES | COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O |
| 分子量 | 316.26 |
| Beilstein号 | 44723 |
| Reaxy-Rn | 44723 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=44723&ln= |
| 密度 | 1.634 |
|---|---|
| 敏感性 | 对光线敏感 |
| 熔点 | 307°C |
| 分子量 | 316.260 g/mol |
| XLogP3 | 1.900 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 316.058 Da |
| 单同位素质量Monoisotopic Mass | 316.058 Da |
| 拓扑极表面积Topological Polar Surface Area | 116.000 Ų |
| 重原子数Heavy Atom Count | 23 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 503.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H351: 怀疑引起遗传缺陷 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 |
| WGK Germany | 3 |
| RTECS | LK9275450 |
| 个人防护装备 | Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
¥576.72
¥257.90
¥519.90
¥870.90
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