MEK - MAPK/ERK 信号通路 - 按“信号通路”分类

阿折地平

规格或纯度 :

≥99%

CAS号: 123524-52-7

分子式: C₃₃H₃₄N₄O₆ 分子量: 582.65

IUPAC Name: 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

SMILES: CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C

InChIKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N

InChI: 1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

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AZD8330,变构MEK抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 869357-68-6

分子式: C₁₆H₁₇FIN₃O₄ 分子量: 461.23

IUPAC Name: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide

SMILES: CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

InChIKey: RWEVIPRMPFNTLO-UHFFFAOYSA-N

InChI: 1S/C16H17FIN3O4/c1-9-7-11(15(23)20-25-6-5-22)14(21(2)16(9)24)19-13-4-3-10(18)8-12(13)17/h3-4,7-8,19,22H,5-6H2,1-2H3,(H,20,23)

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盐酸利多卡因一水合物

规格或纯度 :

Moligand™

≥98%

CAS号: 6108-05-0

分子式: C₁₄H₂₂N₂O · HCl · H₂O 分子量: 288.81

IUPAC Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride

SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.O.Cl

InChIKey: YECIFGHRMFEPJK-UHFFFAOYSA-N

InChI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

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贝美替尼

规格或纯度 :

Moligand™

≥98%

CAS号: 606143-89-9

分子式: C₁₇H₁₅BrF₂N₄O₃ 分子量: 441.23

IUPAC Name: 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide

SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

InChIKey: ACWZRVQXLIRSDF-UHFFFAOYSA-N

InChI: 1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

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1-O-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱

规格或纯度 :

Moligand™

≥98%

CAS号: 74389-68-7

分子式: C₂₆H₅₄NO₇P 分子量: 523.68

IUPAC Name: [(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

SMILES: CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C

InChIKey: HVAUUPRFYPCOCA-AREMUKBSSA-N

InChI: 1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

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PD318088,非ATP竞争性MEK1 / 2抑制剂

规格或纯度 :

≥98%

CAS号: 391210-00-7

分子式: C₁₆H₁₃BrF₃IN₂O₄ 分子量: 561.1

IUPAC Name: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

SMILES: C1=CC(=C(C=C1I)F)NC2=C(C(=C(C=C2C(=O)NOCC(CO)O)Br)F)F

InChIKey: XXSSGBYXSKOLAM-UHFFFAOYSA-N

InChI: 1S/C16H13BrF3IN2O4/c17-10-4-9(16(26)23-27-6-8(25)5-24)15(14(20)13(10)19)22-12-2-1-7(21)3-11(12)18/h1-4,8,22,24-25H,5-6H2,(H,23,26)

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PD0325901,MEK1 / 2的抑制剂

规格或纯度 :

Moligand™

≥99%

CAS号: 391210-10-9

分子式: C₁₆H₁₄F₃IN₂O₄ 分子量: 482.19

IUPAC Name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

InChIKey: SUDAHWBOROXANE-SECBINFHSA-N

InChI: 1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

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2-(2-氨基-3-甲氧苯基)色酮

规格或纯度 :

Moligand™

≥98%

CAS号: 167869-21-8

分子式: C₁₆H₁₃NO₃ 分子量: 267.28

IUPAC Name: 2-(2-amino-3-methoxyphenyl)chromen-4-one

SMILES: COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2

InChIKey: QFWCYNPOPKQOKV-UHFFFAOYSA-N

InChI: 1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

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SL-327,MEK抑制剂

规格或纯度 :

Moligand™

≥98%
mixture of isomers

CAS号: 305350-87-2 Compound CID : 9549284

分子式: C₁₆H₁₂F₃N₃S 分子量: 335.35

IUPAC Name: (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile

SMILES: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

InChIKey: JLOXTZFYJNCPIS-FYWRMAATSA-N

InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

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司美替尼 (AZD6244)

规格或纯度 :

Moligand™

≥99%

CAS号: 606143-52-6 Compound CID : 10127622

分子式: C₁₇H₁₅BrClFN₄O₃ 分子量: 457.69

IUPAC Name: 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide

SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

InChIKey: CYOHGALHFOKKQC-UHFFFAOYSA-N

InChI: 1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

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曲美替尼 (GSK1120212)

规格或纯度 :

Moligand™

≥98%

CAS号: 871700-17-3 Compound CID : 11707110

分子式: C₂₆H₂₃FIN₅O₄ 分子量: 615.39

IUPAC Name: N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide

SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5

InChIKey: LIRYPHYGHXZJBZ-UHFFFAOYSA-N

InChI: 1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

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TAK-733

规格或纯度 :

Moligand™

≥96%

CAS号: 1035555-63-5 Compound CID : 24963252

分子式: C₁₇H₁₅F₂IN₄O₄ 分子量: 504.23

IUPAC Name: 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione

SMILES: CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O

InChIKey: RCLQNICOARASSR-SECBINFHSA-N

InChI: 1S/C17H15F2IN4O4/c1-23-15-12(16(27)24(7-21-15)5-9(26)6-25)14(13(19)17(23)28)22-11-3-2-8(20)4-10(11)18/h2-4,7,9,22,25-26H,5-6H2,1H3/t9-/m1/s1

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