| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G422386-1ml |
1ml |
现货  |
|
| 英文别名 | Galanthamine hydrobromide | Galantamine hydrobromide | 1953-04-4 | Reminyl | Nivalin | Nivaline | Lycoremine hydrobromide | Jilkon hydrobromide | Razadyne | Tamilin | Galanthamine (hydrobromide) | MJ4PTD2VVW | Nivaline (pharmaceutical) | Jilcon hydrobromide | (-)-Galantamine Hydrobr |
|---|---|
| 规格或纯度 | 10mM in Water |
| 英文名称 | Galantamine Hydrobromide |
| 生化机理 | 氢溴酸加兰他敏是一种长效、中枢活性乙酰胆碱酯酶抑制剂（IC50 = 410 nM），也是神经元烟碱 ACh 受体的异位增效剂。氢溴酸加兰他敏可防止β-淀粉样蛋白诱导的SH-SY5Y和牛绒毛膜细胞凋亡。碱性乙酰胆碱酯酶抑制剂（对 AChE 和丁酰胆碱酯酶的 IC 50 值分别为 0.85 和 12.1 μM）。可透过血脑屏障。口服后在体内具有活性。防止β-淀粉样蛋白诱导的细胞凋亡。减少神经元 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
胆碱酯酶抑制剂(Cholinesterase inhibitor),逆转东莨菪碱引起的失忆 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 217-780-5 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide |
| INCHI | 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1 |
| InChi Key | QORVDGQLPPAFRS-XPSHAMGMSA-N |
| Smiles | CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br |
| Isomeric SMILES | CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O.Br |
| 分子量 | 368.27 |
| Beilstein号 | 27(3/4)2184 |
| Reaxy-Rn | 40264879 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40264879&ln= |
| 敏感性 | 对光、热和湿度敏感 |
|---|---|
| 比旋光度 | -95 ° (C=1.4, H2O) |
| 熔点 | 256°C |
| 分子量 | 368.300 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 367.078 Da |
| 单同位素质量Monoisotopic Mass | 367.078 Da |
| 拓扑极表面积Topological Polar Surface Area | 41.900 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 440.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | DF8075000 |
| Merck Index | 4340 |
| 个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
| 1. Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang. (2022) Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells. MOLECULES, 27 (22): (7971). [PMID:36432070] [10.3390/molecules27227971] |
| 2. Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang. (2022) Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. Foods, 11 (2): (168). [PMID:35053900] [10.3390/foods11020168] |
| 3. Pei-Pei WANG, Guo-Wei ZHAO, Wen XIA, En-Ji HAN, Lan XIANG. (2014) A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz. Chinese Journal of Natural Medicines, 12 (377). [PMID:24856762] [10.1016/S1875-5364(14)60047-9] |
| 4. Ping Chen, Pei-Pei Wang, Ze-Zhao Jiao, Lan Xiang. (2014) Sesquiterpenoids from the Fruits of Alpinia oxyphylla and Their Anti-Acetylcholinesterase Activity. HELVETICA CHIMICA ACTA, 97 (3): (388-397). [10.1002/hlca.201300234] |
| 5. Chang Xu, Xiao Yu, Guiyang Wang, Shiqing You, Linlin Zhu, Ying Liu, Nuan Zhang, Zhengdong Wang, Bin Liu, Wei Zhang. (2024) Affinity ultrafiltration based metabolomic profiling directed discovery novel butyrylcholinesterase inhibitors from Uncaria sessilifructus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (134179). [PMID:39084425] [10.1016/j.ijbiomac.2024.134179] |
| 6. Chen Zhan, Jiahui Zhang, Junxing Hao, Zhihong Liu, Chengguo Hu. (2024) Scalable drop-casting construction of light-addressable photoelectrochemical biosensor on laser-induced graphene electrode arrays for high-throughput drug screening. BIOSENSORS & BIOELECTRONICS, 261 (116497). [PMID:38878700] [10.1016/j.bios.2024.116497] |
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