Galantamine Hydrobromide

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Galanthus woronowii

Galantamine Hydrobromide is the pharmaceutical form of galantamine, which is a naturally occurring alkaloid originally isolated from plants in the Amaryllidaceae family — notably Galanthus woronowii (commonly called Woronow’s snowdrop).

Galantamine Hydrobromide （Aladdin G111443 98%; G422386 10mM in Water） is an acetylcholinesterase inhibitor and an allosteric agonist at both nicotinic and muscarinic acetylcholine receptors, showing partial selectivity for α7 nicotinic acetylcholine receptors. It is clinically used in the management of Alzheimer’s disease and provides a broad neuroprotective window against hypoxic injury.

By inhibiting acetylcholinesterase, galantamine increases synaptic acetylcholine levels, thereby enhancing acetylcholine-mediated receptor signaling. It also raises the density of nicotinic acetylcholine receptors, supporting improved synaptic transmission, cognitive performance, and long-term potentiation. Additionally, galantamine promotes hippocampal neurogenesis in animal models via an IGF2-dependent mechanism.

Galantamine’s neuroprotective effects in Alzheimer’s disease extend beyond cholinergic modulation. It reduces oxidative damage to neurons by inhibiting P2X7 receptor activation and helps preserve membrane fluidity, thereby maintaining neuronal integrity.

References:

1. Dengiz AN, Kershaw P. CNS Spectr. 2004 May;9(5):377-92.

2. Sobrado M, Roda JM, López MG, et al. Neurosci Lett. 2004 Jul 22;365(2):132-6.

3. Svedberg MM, Bednar I, Nordberg A. Neuropharmacology. 2004 Sep;47(4):558-71.

4. Kita Y, Ago Y, Higashino K, et al. Int J Neuropsychopharmacol. 2014 Dec;17(12):1957-68.

5. Tsvetkova D, Obreshkova D, Zheleva-Dimitrova D, et al. Curr Med Chem. 2013;20(36):4595-608.

Aladdin: https://www.aladdinsci.com/